DRAM2 Antibody | EMD Millipore MABC64 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

DRAM2 Antibody

catalog :

MABC64

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4H6.1

reactivity :

human

application :

western blot

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; loading ...; fig 4a	Wei R, Lin S, Wu W, Chen L, Li C, Chen H, et al. A microtubule inhibitor, ABT-751, induces autophagy and delays apoptosis in Huh-7 cells. Toxicol Appl Pharmacol. 2016;311:88-98 pubmed publisher

product information

Catalog Number :

MABC64

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-DRAM2 Antibody

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q6UX65

Host Name :

Mouse

Antigen :

DRAM2

Clone :

4H6.1

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-DRAM2 Antibody

Cross Reactivity :

Human

Background :

Damage-Regulated Autophagy Modulator (DRAM) is a lysosomal protein that acts as an effector molecule that is critical for autophagy and p53-mediated apoptosis. In humans, there are 5 known proteins that show significant homology to DRAM. The closest of these proteins is DRAM2, which displays 67% conservation when compared to DRAM. However, unlike DRAM, DRAM2 is not induced by p53 or p73. Additionally, it does not modulate autophagy in contrast with DRAM. DRAM2 is known to be co-localized with DRAM in lysosomes, and co-expression with DRAM is shown to significantly increase cell death.

ALT Names :

DNA damage-regulated autophagy modulator protein 2;Transmembrane protein 77

Immunogen :

Linear peptide corresponding to the human DRAM2

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt