VEGF 165b Antibody, clone 56/1 | EMD Millipore MABC595 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

VEGF 165b Antibody, clone 56/1

catalog :

MABC595

quantity :

200 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

56/1

The same clone is also sold as:

R&D Systems: MAB3045-100

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; loading ...; fig 2	Chu L, Ganta V, Choi M, Chen G, Finley S, Annex B, et al. A multiscale computational model predicts distribution of anti-angiogenic isoform VEGF165b in peripheral arterial disease in human and mouse. Sci Rep. 2016;6:37030 pubmed publisher

product information

Catalog Number :

MABC595

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-VEGF 165b Antibody, clone 56/1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P15692*

Host Name :

Mouse

Antigen :

VEGF165b

Clone :

56/1

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-VEGF 165b Antibody, clone 56/1

Cross Reactivity :

Mouse, Rat, Human

Background :

VEGF (Vascular endothelial growth factor, VEGFA, VEGF-A), a dimeric ligand, is among the most potent angiogenic mitogens. VEGF is secreted by tumor cells and other cells exposed to hypoxia. VEGF is a highly specific mitogen for vascular endothelial cells. Seven VEGF isoforms (a, b, c, d, e, f, g) are generated as a result of alternative splicing from a single VEGF gene. The most commonly studied isoforms are VEGF121, VEGF165, and VEGF189 (f, d and b, respectively) All seven isoforms differ in their molecular mass and in biological properties such as their ability to bind to cell-surface heparan-sulfate proteoglycans. The expression of VEGF is potentiated and is secreted by tumor cells in response to hypoxia, by activated oncogenes, and by a variety of cytokines. VEGF induces angiogenesis as well as permeabilization of blood vessels, and plays a central role in the regulation of vasculogenesis. VEGF expression correlates to the degree of tumor vascularization and with increased metastatic risk. Additionally, VEGF induces endothelial cell proliferation, promotes cell migration, and inhibits apoptosis. Consequently, inhibition of VEGF signaling abrogates the development of a wide variety of tumors.

ALT Names :

Vascular endothelial growth factor 165b, Vascular endothelial growth factor 165, Vascular endothelial growth factor A, Vascular permeability factor

Immunogen :

KLH-conjugated linear peptide corresponding to the C-terminus of Mouse VEGF 165b.

Package Size :

200 μg

Uses :

Western Blotting, Immunohistochemistry, ELISA

Storage :

Stable for 1 year at 2-8°C from date of receipt