TRP1/TYRP1 Antibody, clone TA99, Azide Free | EMD Millipore MABC592 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

TRP1/TYRP1 Antibody, clone TA99, Azide Free

catalog :

MABC592

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

TA99

The same clone is also sold as:

OriGene: AM33299PU-T, AM33299PU-S
Invitrogen: MA5-12293
BioLegend: 917801
Bio X Cell: BE0151-50MG, BE0151-100MG, BE0151-25MG, BE0151-5MG, BE0151-1MG
Novus Biologicals: NBP2-32906-0.1mg, NBP2-34720-0.1 mg
Absolute Antibody: Ab00180-10.3, Ab00180-23.0, Ab00180-2.0, Ab00180-10.0
LifeSpan Biosciences: LS-C87814, LS-C87815
MyBioSource: MBS438198
Santa Cruz Biotechnology: sc-58438
Abcam: ab3312

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation, flow cytometry

product information

Catalog Number :

MABC592

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-TRP1/TYRP1 Antibody, clone TA99, Azide Free

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P17643

Host Name :

Mouse

Antigen :

TYRP1

Clone :

TA99

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG2aκ

Product Description :

Anti-TRP1/TYRP1 Antibody, clone TA99, Azide Free

Cross Reactivity :

Mouse, Human

Background :

TRP1/TYRP1, also known as 5,6-dihydroxyindole-2-carboxylic acid oxidase, DHICA, Catalase B, Glycoprotein 75, Melanoma antigen gp75, or Tyrosinase-related protein 1 (TRP/TRP-1/TRP1), and encoded by the gene TYRP1/CAS2/TYRP/TYRRP, is involved in melanin synthesis and is the enzyme that oxidizes DHICA into indole-5,6-quinone-2-carboxylic acid in the pathway. TRP1/TYRP1 is critical for skin/eye/hair pigmentation. Mutations are associated with Albinism. TRP1/TYRP1 is regulated by the microphthalmia-associated transcription factor (MITF). MITF is a master regulator of pigmentation and a target of β-catenin in Wnt/β-catenin signaling during melanocyte differentiation. TRP1/TYRP1 is also regulated by the microRNA miR-145, and this microRNA is being examined as a possible therapy for hyperpigmentation. TRP1/TYRP1 is expressed as a membrane protein in melanosomes and endosomes in pigment cells.

ALT Names :

5,6-dihydroxyindole-2-carboxylic acid oxidase, DHICA oxidase, Catalase B, Glycoprotein 75, Melanoma antigen gp75, Tyrosinase-related protein 1, TRP, TRP-1, TRP1

Immunogen :

Whole cells corresponding to human TRP1/TYRP1.

Package Size :

100 μg

Uses :

Western Blotting, Immunohistochemistry, Blocking of Inteferring Antibodies, Immunoprecipitation, Flow Cytometry

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.