FANCM Antibody, clone CV5.1 | EMD Millipore MABC545 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

FANCM Antibody, clone CV5.1

catalog :

MABC545

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CV5.1

The same clone is also sold as:

OriGene: TA353183L
Novus Biologicals: NBP2-50418

reactivity :

human

application :

western blot, immunocytochemistry

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:100; fig 2a	Bogliolo M, Bluteau D, Lespinasse J, Pujol R, Vasquez N, d Enghien C, et al. Biallelic truncating FANCM mutations cause early-onset cancer but not Fanconi anemia. Genet Med. 2018;20:458-463 pubmed publisher
	Vuono E, Mukherjee A, Vierra D, Adroved M, Hodson C, Deans A, et al. The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair. Sci Rep. 2016;6:36439 pubmed publisher

product information

Catalog Number :

MABC545

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-FANCM Antibody, clone CV5.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q8IYD8

Host Name :

Mouse

Antigen :

FANCM

Clone :

CV5.1

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-FANCM Antibody, clone CV5.1

Cross Reactivity :

Human

Background :

FANCM, also known as Fanconi anemia group M protein (FACM), or ATP-dependent RNA helicase FANCM, or Fanconi anemia-associated polypeptide of 250 kDa (FAAP250), or Protein Hef ortholog, and encoded by the gene FANCM/KIAA1596,is a critical ATPase needed for proper DNA repair. FANCM is found at DNA replication forks and required for cellular resistance to DNA cross-linking agents and for proper DNA repair. FANCM belongs to a multi-subunit FA (Fanconi anemia) complex. FANCM is localized to the nucleus and expressed in most cells. Defects in FANCM may be associated with Fanconi anemia complementation group M (FANCM) a disorder affecting hematopoietic cells can causing anemia, leukopenia and thrombopenia. Patients also have cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition toward malignancies. Patient’s cells show hypersensitivity to DNA-damaging agents, chromosomal instability and defective DNA repair.

ALT Names :

Fanconi anemia group M protein, Protein FACM, ATP-dependent RNA helicase FANCM, Fanconi anemia-associated polypeptide of 250 kDa, FAAP250, Protein Hef ortholog

Immunogen :

His-tagged recombinant protein corresponding to human FANCM.

Package Size :

100 µL

Uses :

Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt