PLK-4 Antibody, clone 6H5 | EMD Millipore MABC544 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PLK-4 Antibody, clone 6H5

catalog :

MABC544

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6H5

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; 1:500; loading ...; fig 6a	Luo Y, Barrios Rodiles M, Gupta G, Zhang Y, Ogunjimi A, Bashkurov M, et al. Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility. Nat Commun. 2019;10:2356 pubmed publisher
immunocytochemistry; human; 1:500	Ohta M, Ashikawa T, Nozaki Y, Kozuka Hata H, Goto H, Inagaki M, et al. Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole. Nat Commun. 2014;5:5267 pubmed publisher
	Takao D, Watanabe K, Kuroki K, Kitagawa D. Feedback loops in the Plk4-STIL-HsSAS6 network coordinate site selection for procentriole formation. Biol Open. 2019;8: pubmed publisher
	Arquint C, Gabryjonczyk A, Imseng S, BÃ¶hm R, Sauer E, Hiller S, et al. STIL binding to Polo-box 3 of PLK4 regulates centriole duplication. elife. 2015;4: pubmed publisher

product information

Catalog Number :

MABC544

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-PLK-4 Antibody, clone 6H5

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O00444

Host Name :

Mouse

Antigen :

PLK-4

Clone :

6H5

Conjugate :

Purified

Isotype :

IgG3κ

Product Description :

Anti-PLK-4 Antibody, clone 6H5

Cross Reactivity :

Human

Background :

Serine/threonine-protein kinase PLK4 (PLK-4) is a member of the protein kinase superfamily and plays an essential role in centriole duplication. PLK-4 triggers procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins. It may be involved in tumorigenesis since centrosome aberrations are frequently observed in tumors. PLK-4 may also be involved in trophoblast differentiation by phosphorylating HAND1, leading to the disruption between HAND1 and MDFIC and then activating HAND1.

ALT Names :

Serine/threonine-protein kinase PLK4;Polo-like kinase 4;PLK-4;Serine/threonine-protein kinase 18;Serine/threonine-protein kinase Sak

Immunogen :

Linear peptide corresponding to Human PLK-4.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry;Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt