BIRC2/IAP-2, clone 1E1-1-10 | EMD Millipore MABC535 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

BIRC2/IAP-2, clone 1E1-1-10

catalog :

MABC535

quantity :

100 μg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

1E1-1-10

The same clone is also sold as:

Enzo Life Sciences: ALX-803-335-C100

reactivity :

human, mouse

application :

western blot

product information

Catalog Number :

MABC535

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-BIRC2/IAP-2, clone 1E1-1-10

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q62210, Q13490

Host Name :

Rat

Antigen :

Birc2

Clone :

1E1-1-10

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG2aκ

Product Description :

Anti-BIRC2/IAP-2, clone 1E1-1-10

Cross Reactivity :

Mouse, Human

Background :

BRC2/IAP-2, also known as IAP homolog B, Inhibitor of apoptosis protein 2 and Baculoviral IAP repeat-containing protein 2, and encoded by the gene BIRC2/API1/IAP2/MIHB/ RNF48, is a multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. BIRC2/IAP-2 also acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical pathways. Additionally, BIRC2/IAP-2 acts as an important regulator of innate immune signaling, and finally, BIRC2/IAP-2 plays an important role in the modulation of the cell cycle. BIRC2/IAP-21 is localized to nucleus except during apoptotic events. BIRC2/IAP-2 is expressed in fetal and adult tissues with a strong emphasis found in adult skeletal muscle, thymus, testis, ovary and pancreas with low or absent expression in blood and brain.

ALT Names :

Baculoviral IAP repeat-containing protein 2, Inhibitor of apoptosis protein 2, IAP-2, mIAP-2, mIAP2

Immunogen :

Linear peptide corresponding to the BIR 2 repeat region of mouse BIRC2/IAP-2.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt