FANCC Antibody, clone 8F3 | EMD Millipore MABC524 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

FANCC Antibody, clone 8F3

catalog :

MABC524

quantity :

200 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8F3

The same clone is also sold as:

LifeSpan Biosciences: LS-C142662, LS-C142661, LS-C142660, LS-C142664

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation, western blot knockout validation

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; human; 1:500; loading ...; fig s1b	Zou X, Owusu M, Harris R, Jackson S, Loizou J, Nik Zainal S. Validating the concept of mutational signatures with isogenic cell models. Nat Commun. 2018;9:1744 pubmed publisher
	Moder M, Velimezi G, Owusu M, Mazouzi A, Wiedner M, Ferreira da Silva J, et al. Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia. Nat Commun. 2017;8:1238 pubmed publisher

product information

Catalog Number :

MABC524

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-FANCC Antibody, clone 8F3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q00597

Host Name :

Mouse

Antigen :

FANCC

Clone :

8F3

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG2bκ

Product Description :

Anti-FANCC Antibody, clone 8F3

Cross Reactivity :

Rat, Mouse, Human

Background :

Fanconi anemia (FA) is an inherited bone marrow failure syndrome associated with a progressive decline in hematopoietic stem cells, developmental defects, and predisposition to cancer. FANCC is part of the multisubunit Fanconi anemia (FA) complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. FANCC is a primarily nuclear localized DNA repair protein that is believed to function in interstrand DNA cross-link repair and the maintenance of normal chromosome stability. Mutations in FANCC are associated with various aspects of FA. New research shows that FANCC is critical for resistance to DNA cross-linking drug-induced DNA damage in cells patients with myeloproliferative neoplasms. Also, FANCC interacts with the C-terminal-binding protein-1 (CtBP1) involved in transcriptional regulation, including being a negative regulator of Dickkopf-1 (DKK1) expression. This down regulation does not occur in mutations of FANCC, which then leads to up-regulation of DKK1, a molecule involved in hematopoietic malignancies.

ALT Names :

Fanconi anemia group C protein, Protein FACC, FANCC

Immunogen :

Linear peptide corresponding to Human FANCC.

Package Size :

200 μg

Uses :

Western Blotting, Immunoprecipitation, Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt