MAP17 Antibody, clone 165C | EMD Millipore MABC522 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MAP17 Antibody, clone 165C

catalog :

MABC522

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

165C

reactivity :

human

application :

western blot, immunohistochemistry

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:500; loading ...; fig s1b	García Heredia J, Lucena Cacace A, Verdugo Sivianes E, PÃ©rez M, Carnero A. The Cargo Protein MAP17 (PDZK1IP1) Regulates the Cancer Stem Cell Pool Activating the Notch Pathway by Abducting NUMB. Clin Cancer Res. 2017;23:3871-3883 pubmed publisher

product information

Catalog Number :

MABC522

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-MAP17 Antibody, clone 165C

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q13113

Host Name :

Mouse

Antigen :

MAP17

Clone :

165C

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-MAP17 Antibody, clone 165C

Cross Reactivity :

Human

Background :

The protein named PDZK1-interacting protein 1 or alternatively 17kDa membrane-associated protein DD96 or MAP17 and encoded by the human gene named PDZK1IP1 or MAP17 is a highly unusual protein being naturally expressed only in a single epithelial cell population found in the proximal tubular epithelial cells. However, MAP17 is expressed in cancerous tissue of the kidney, colon, lung and breast. MAP17 expression in cancers causes an increase in reactive oxygen species production and tumorigenesis in cancerous tissues. These factors are mediated though MAP17’s PDZ-binding domain because disruption of this sequence by point mutations abolishes the ability of MAP17 to enhance ROS production and tumorigenesis. MAP17 also often serves as a cancer cell marker to distinguish tumor margins and tumorigenesis potential. MAP17 is a membrane bound protein and is thought to be a putative oncogene but its exact function in normal cells is still being researched.

ALT Names :

PDZK1-interacting protein 1;17 kDa membrane-associated protein;Protein DD96

Immunogen :

GST-tagged recombinant protein corresponding to human MAP17.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt