Trop2, clone 2G10, Azide Free | EMD Millipore MABC519 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Trop2, clone 2G10, Azide Free

catalog :

MABC519

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2G10

reactivity :

human

application :

immunocytochemistry, flow cytometry

product information

Catalog Number :

MABC519

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Trop2, clone 2G10, Azide Free

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P09758

Host Name :

Mouse

Antigen :

TACSTD2

Clone :

2G10

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG2aκ

Product Description :

Anti-Trop2, clone 2G10, Azide Free

Cross Reactivity :

Human

Background :

The protein known as Trop-2, or also known as cell surface glycoprotein Trop-2, Membrane component chromosome 1 surface marker 1 or Pancreatic carcinoma marker protein GA733-1 and encoded by the gene TACSTD2/GA733-1/M1S1/TROP2, is a protein that may function as a growth factor receptor and is expressed primarily in the placenta, lung and epithelial tissues but also found in certain cancers. The protein was first identified as a carcinoma antigen by the monoclonal GA733. It is a plasma membrane bound protein that transduces an intracellular calcium signal after binding unknown ligands. Mutations in Trop2 are associated with a rare eye disease leading to blindness. Trop-2 has also recently been shown to be important in regulating fibroblast motility and lung cell proliferation via the regulation of the ERK kinase pathway as well as several critical components of the cell migration apparatus.

ALT Names :

Tumor-associated calcium signal transducer 2, Cell surface glycoprotein Trop-2, Membrane component chromosome 1 surface marker 1, Pancreatic carcinoma marker protein GA733-1

Immunogen :

Recombinant protein corresponding to the extracellular domain of human Trop2.

Package Size :

100 μg

Uses :

Immunocytochemistry, Flow Cytometry, Inhibition

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.