LAMP-3 Antibody, clone 16H11.2 | EMD Millipore MABC44 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

LAMP-3 Antibody, clone 16H11.2

catalog :

MABC44

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

16H11.2

reactivity :

human

application :

western blot, immunohistochemistry

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human	Domínguez Bautista J, Klinkenberg M, Brehm N, Subramaniam M, Kern B, Roeper J, et al. Loss of lysosome-associated membrane protein 3 (LAMP3) enhances cellular vulnerability against proteasomal inhibition. Eur J Cell Biol. 2015;94:148-61 pubmed publisher

product information

Catalog Number :

MABC44

Subcategory :

Cell Structure

Product Name :

Anti-LAMP-3 Antibody, clone 16H11.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9UQV4

Host Name :

Mouse

Antigen :

LAMP-3

Clone :

16H11.2

Conjugate :

Purified

Isotype :

IgG2bκ

Product Description :

Anti-LAMP-3 Antibody, clone 16H11.2

Cross Reactivity :

Human

Background :

Lysosyme-associated membrane proteins (LAMP) are transmembrane lysosomal glycoproteins, which share a common Gly-Tyr motif as a lysosomal targeting signal. While LAMP-1 and LAMP-2 contain type 1 transmembrane domains, LAMP-3 contains a transmembrane 4 superfamily domain, tetraspanin. FceRI-mediated stimulation of basophils causes LAMP-3 to be translocated from its intracellular localization to the plasma membrane. LAMP-3 thereby serves as a reliable marker for basophil activation. LAMP-3 expression is known to be reported in human bone marrow mast cells and in leukemic human mast cell line (HMC-1), among other cell lines. LAMP3 is shown to be regulated by hypoxia in a panel of tumor cells, via the unfolded protein response (UPR). UPR is a mechanism of adaptation to endoplasmic reticulum stress and is demonstrated to contribute to hypoxic adaptation in tumors through multiple mechanisms.

ALT Names :

LAMP;CD208;LAMP-3;DC-loysosome-associated membrane glycoprotein;DC LAMP;DC-LAMP;Protein TSC403

Immunogen :

Recombinant protein corresponding to human LAMP-3.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt