Mcl-1 Antibody, clone RC13 | EMD Millipore MABC43 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Mcl-1 Antibody, clone RC13

catalog :

MABC43

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

RC13

The same clone is also sold as:

Invitrogen: MA5-13932, AHO0102
LifeSpan Biosciences: LS-C88366, LS-C88368
Santa Cruz Biotechnology: sc-56152

reactivity :

human

application :

western blot, immunohistochemistry, immunoprecipitation

citations: 4

Published Application/Species/Sample/Dilution	Reference
western blot; human	Rayavarapu R, Heiden B, Pagani N, Shaw M, Shuff S, Zhang S, et al. The role of multicellular aggregation in the survival of ErbB2-positive breast cancer cells during extracellular matrix detachment. J Biol Chem. 2015;290:8722-33 pubmed publisher
	Shen Q, Li J, Mai J, Zhang Z, Fisher A, Wu X, et al. Sensitizing non-small cell lung cancer to BCL-xL-targeted apoptosis. Cell Death Dis. 2018;9:986 pubmed publisher
	Weigel K, Jakimenko A, Conti B, Chapman S, Kaliney W, Leevy W, et al. CAF-secreted IGFBPs regulate breast cancer cell anoikis. Mol Cancer Res. 2014;12:855-66 pubmed publisher
	High L, Szymanska B, Wilczynska Kalak U, Barber N, O Brien R, Khaw S, et al. The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs. Mol Pharmacol. 2010;77:483-94 pubmed publisher

product information

Catalog Number :

MABC43

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Mcl-1 Antibody, clone RC13

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q07820

Host Name :

Mouse

Antigen :

Mcl-1

Clone :

RC13

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Mcl-1 Antibody, clone RC13

Cross Reactivity :

Human

Background :

Mcl-1 (Induced myeloid leukemia cell differentiation protein) is a potential transmembrane protein associated with the mitochondria belonging to the Bcl-2 family of proteins. Members of the Bcl-2 family have known participation in regulatory roles for apoptosis, cell growth, and differentiation. The hydrophobic carboxyl terminus is conserved among members of this family and in other members has proven to be a transmembrane region. Mcl-1 is found to be expressed early in myeloid differentiation. Two separate isoforms of Mcl-1 exist with opposing functions. Full length Mcl-1 (Isoform 1) promotes cell viability, over proliferation. Isoform 2 results from the skipping of the central exon of Mcl-1 during mRNA processing and the joining of the first and third exons. The function of the resulting protein induces apoptosis when accumulated. Pro-apoptotic function is shown to increase when isoform 1 and 2 dimerize.

ALT Names :

myeloid cell leukemia sequence 1 (BCL2-related);myeloid cell leukemia sequence 1, isoform 1;Bcl-2-like protein 3;Bcl-2-related protein EAT/mcl1;myeloid cell leukemia ES;induced myeloid leukemia cell differentiation protein Mcl-1

Immunogen :

Recombinant protein corresponding to human Mcl-1.

Package Size :

100 µL

Uses :

Western Blotting;Immunohistochemistry;Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt