LAMP-2 Antibody, clone ABL-93 | EMD Millipore MABC40 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

LAMP-2 Antibody, clone ABL-93

catalog :

MABC40

quantity :

100 μg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

ABL-93

The same clone is also sold as:

Santa Cruz Biotechnology: sc-20004
OriGene: AM08088PU-N, AM08088FC-N, AM08088AC-N
SouthernBiotech: 1921-01
Abnova: MAB5837, MAB3266, MAB5838
LifeSpan Biosciences: LS-C350607, LS-C350586, LS-C196123, LS-C350582
BioLegend: 816101, 816104, 816106, 816103, 816105
Invitrogen: A15449, RMCD107B01
Developmental Studies Hybridoma Bank: ABL-93

reactivity :

mouse

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 6

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; mouse; 1:500; loading ...; fig 1f	Bagh M, Peng S, Chandra G, Zhang Z, Singh S, Pattabiraman N, et al. Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model. Nat Commun. 2017;8:14612 pubmed publisher
	Paolicelli R, Jawaid A, Henstridge C, Valeri A, Merlini M, Robinson J, et al. TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss. Neuron. 2017;95:297-308.e6 pubmed publisher
	Villalpando Rodriguez G, Torriglia A. Calpain 1 induce lysosomal permeabilization by cleavage of lysosomal associated membrane protein 2. Biochim Biophys Acta. 2013;1833:2244-53 pubmed publisher
	Malicdan M, Noguchi S, Tokutomi T, Goto Y, Nonaka I, Hayashi Y, et al. Peracetylated N-acetylmannosamine, a synthetic sugar molecule, efficiently rescues muscle phenotype and biochemical defects in mouse model of sialic acid-deficient myopathy. J Biol Chem. 2012;287:2689-705 pubmed publisher
	Stroobants S, Gerlach D, Matthes F, Hartmann D, Fogh J, Gieselmann V, et al. Intracerebroventricular enzyme infusion corrects central nervous system pathology and dysfunction in a mouse model of metachromatic leukodystrophy. Hum Mol Genet. 2011;20:2760-9 pubmed publisher
	van Meel E, Boonen M, Zhao H, Oorschot V, Ross F, Kornfeld S, et al. Disruption of the Man-6-P targeting pathway in mice impairs osteoclast secretory lysosome biogenesis. Traffic. 2011;12:912-24 pubmed publisher

product information

Catalog Number :

MABC40

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-LAMP-2 Antibody, clone ABL-93

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P17047

Host Name :

Rat

Antigen :

LAMP-2

Clone :

ABL-93

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-LAMP-2 Antibody, clone ABL-93

Cross Reactivity :

Mouse

Background :

Lysosome-associated membrane protein 2 (LAMP-2) is a highly glycosolated protein belonging to the lysosome-associated membrane protein family. This group pf proteins composes a significant portion of the lysosomal membrane and are considered crucial mediators for cellular adhesion by interacting with carbohydrate receptors. LAMP-2 is a profuse and critical component of the lysosomal membrane as it has been implicated in playing a role in lysosomal biogenesis. It also appears to be involved in later stages of phagocytosis and autophagy, where it may act to protect the lysosomal membrane from being digested, assist in signal transduction, moderate levels of acidity within the lysosomal environment, and participate in adhesion. Mutations in LAMP-2 expression have been associated with lysosomal storage diseases or LSDs, along with Danon disease, an X-linked disorder characterized by skeletal myopathy, mental retardation, and hypertrophic cardiomyopathy.

ALT Names :

lysosomal-associated membrane protein 2;CD107 antigen-like family member B;CD107b antigen

Immunogen :

Purified glycoproteins from NIH/3T3 cells, corresponding to mouse LAMP-2.

Specificity :

This antibody recognizes LAMP-2.

Package Size :

100 μg

Uses :

Western Blotting;Immunoprecipitation;Immunofluorescence

Storage :

Stable for 1 year at 2-8°C from date of receipt