p62 (Sequestosome-1) Antibody, clone 11C9.2 | EMD Millipore MABC32 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

p62 (Sequestosome-1) Antibody, clone 11C9.2

catalog :

MABC32

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

11C9.2

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry

citations: 8

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; 1:1000; loading ...; fig 4a	Shiihashi G, Ito D, Yagi T, Nihei Y, Ebine T, Suzuki N. Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice. Brain. 2016;139:2380-94 pubmed publisher
western blot; mouse; 1:1000; fig 7	Caccamo A, Branca C, Talboom J, Shaw D, Turner D, Ma L, et al. Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease. J Neurosci. 2015;35:14042-56 pubmed publisher
western blot; rat; 1:1000	Parafati M, Lascala A, Morittu V, Trimboli F, Rizzuto A, Brunelli E, et al. Bergamot polyphenol fraction prevents nonalcoholic fatty liver disease via stimulation of lipophagy in cafeteria diet-induced rat model of metabolic syndrome. J Nutr Biochem. 2015;26:938-48 pubmed publisher
western blot; human	Moon J, Eo S, Lee J, Park S. Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death. Oncol Rep. 2015;34:375-81 pubmed publisher
western blot; mouse	Polajnar M, Zavasnik Bergant T, Skerget K, Vizovišek M, Vidmar R, Fonovic M, et al. Human stefin B role in cell's response to misfolded proteins and autophagy. PLoS ONE. 2014;9:e102500 pubmed publisher
	Valapala M, Wilson C, Hose S, Bhutto I, Grebe R, Dong A, et al. Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/?A3/A1-crystallin via V-ATPase-MTORC1 signaling. Autophagy. 2014;10:480-96 pubmed publisher
	Jerič B, Dolenc I, Mihelic M, Klarić M, Zavasnik Bergant T, Guncar G, et al. N-terminally truncated forms of human cathepsin F accumulate in aggresome-like inclusions. Biochim Biophys Acta. 2013;1833:2254-66 pubmed publisher
	Papadakis M, Hadley G, Xilouri M, Hoyte L, Nagel S, McMenamin M, et al. Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy. Nat Med. 2013;19:351-7 pubmed publisher

product information

Catalog Number :

MABC32

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-p62 (Sequestosome-1) Antibody, clone 11C9.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q13501

Host Name :

Mouse

Antigen :

p62 (Sequestosome-1)

Clone :

11C9.2

Conjugate :

Purified

Isotype :

IgMκ

Product Description :

Anti-p62 (Sequestosome-1) Antibody, clone 11C9.2

Cross Reactivity :

Human;Rat;Mouse

Background :

p62 is also known as sequestosome-1, and is a 62 kDa ras-GAP associated protein. p62 is thought to bind to src-family tyrosine kinases and may also provide a linker action for activated src-family kinases with their downstream effectors. p62 has an RNA-binding region and may have RNA-binding ability. p62 is associated with activation of transcription factor NF-κB, involved in cell differentiation, immune response and potassium channel regulation. p62 has recently been linked to extrinsic apoptosis and may be a key player in tumorigenesis.

ALT Names :

sequestosome 1;EBI3-associated protein of 60 kDa;Paget disease of bone 3;phosphotyrosine independent ligand for the Lck SH2 domain p62;oxidative stress induced like;EBI3-associated protein p60;Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa;Ubiquitin-binding protein p62;sequestosome-1

Immunogen :

GST-tagged recombinant protein corresponding to human p62 (Sequestosome-1).

Package Size :

100 μg

Uses :

Western Blotting;Flow Cytometry;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt