phospho-ULK1 (Ser638) Antibody, clone 6B3.2 | EMD Millipore MABC306 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-ULK1 (Ser638) Antibody, clone 6B3.2

catalog :

MABC306

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

6B3.2

reactivity :

human

application :

western blot, immunocytochemistry

product information

Catalog Number :

MABC306

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-phospho-ULK1 (Ser638) Antibody, clone 6B3.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O75385

Host Name :

Mouse

Antigen :

ULK1

Clone :

6B3.2

Conjugate :

Purified

Purification Method :

Purified by ion-exchange chromatography

Isotype :

IgMκ

Product Description :

Anti-phospho-ULK1 (Ser638) Antibody, clone 6B3.2

Cross Reactivity :

Human

Background :

ULK1 or autophagy-related protein 1 homolog (ATG1) is a serine/threonine protein kinase. It is a ubiquitously expressed protein that is highly abundant in the brain, skeletal muscle, and heart. It is involved in the signaling pathway of mTOR receptors leading to the regulation of autophagy in nutrient-deprived cells. mTOR may interact with ULK1 as a complex of ULK1/FIP200/Atg13. Phosphorylation of ULK1 at Ser638 is mediated by mTOR, which is a regulator of cell growth and an inhibitor of autophagy that disrupts the interaction between ULK1 and AMPK. ULK1 may play an important role in neuronal development: Elimination of ULK1's enzymatic activity by targeted disruption of its kinase domain has blocked the outgrowth of neurons in the developing mouse brain, possibly by blocking the ULK1-mediated trafficking of neurotrophins.

ALT Names :

ULK1, Serine/threonine-protein kinase ULK1, Autophagy-related protein 1 homolog, ATG1, hATG1, Unc-51-like kinase 1

Immunogen :

KLH-conjugated linear peptide corresponding to Human phospho-ULK1 (Ser638).

Package Size :

100 μg

Uses :

Western Blotting, Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt