Annexin VI Antibody, clone 4B11.1 | EMD Millipore MABC272 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Annexin VI Antibody, clone 4B11.1

catalog :

MABC272

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4B11.1

reactivity :

human, mouse

application :

western blot, immunocytochemistry

citations: 3

Reference
Matsuyama K, Mizutani Y, Takahashi T, Shu E, Kanoh H, Miyazaki T, et al. Enhanced dendritic cells and regulatory T cells in the dermis of porokeratosis. Arch Dermatol Res. 2017;309:749-756 pubmed publisher
Ma S, Imadojemu S, Beer K, Seykora J. Inflammatory features of frontal fibrosing alopecia. J Cutan Pathol. 2017;44:672-676 pubmed publisher
Friedman K, Brodsky A, Lu S, Wood S, Gill A, Lombardo K, et al. Medullary carcinoma of the colon: a distinct morphology reveals a distinctive immunoregulatory microenvironment. Mod Pathol. 2016;29:528-41 pubmed publisher

product information

Catalog Number :

MABC272

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Annexin VI Antibody, clone 4B11.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P08133

Host Name :

Mouse

Antigen :

ANXA6

Clone :

4B11.1

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG2aκ

Product Description :

Anti-Annexin VI Antibody, clone 4B11.1

Cross Reactivity :

Human, Mouse

Background :

The protein Annexin A6 or alternatively known as 67 kDa calelectrin, Annexin VI, Annexin-6, Calphobindin-II (CPB-II), Chromobindin-20, Lipocortin VI, Protein III, p68, or p70 and encoded by the human gene named ANXA6 or ANX6. Annexin VI is part of a large family of Annexin proteins and shares with the family the ability to bind negatively charged phospholipids in a calcium dependent manner. Localized in the plasma membrane annexins are important in many cellular functions as the provide scaffolds and play roles in vesicle transport, exocytosis, endocytosis and calcium transport and conduction. Recent research indicates that Annexin VI can interact with PKCalpha and EGFR in A431 cells to help regulate the phosphorylation of pY-EGFR and the associated activation of downstream signaling events associated with cancer. Annexin VI in normal tissue is expressed most strongly in myocardial tissue where it associates with sarcomeric α-actinin and is part of the sarcomere structure. Annexin VI also regulates terminal chondrocyte differentiation by modulating key signaling pathway activities.

ALT Names :

Annexin A6, 67 kDa calelectrin, Annexin VI, Annexin-6, Calphobindin-II, CPB-II, Chromobindin-20, Lipocortin VI, Protein III, p68, p70

Immunogen :

GST-tagged recombinant protein corresponding to human Annexin VI.

Package Size :

100 μg

Uses :

Western Blotting, Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt