APC Antibody, clone FE9 | EMD Millipore MABC202 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

APC Antibody, clone FE9

catalog :

MABC202

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

FE9

The same clone is also sold as:

Invitrogen: MA1-91039

reactivity :

human

application :

western blot, western blot knockout validation

citations: 4

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; human; fig 2	Drost J, van Jaarsveld R, Ponsioen B, Zimberlin C, van Boxtel R, Buijs A, et al. Sequential cancer mutations in cultured human intestinal stem cells. Nature. 2015;521:43-7 pubmed publisher
	Zafra M, Schatoff E, Katti A, Foronda M, Breinig M, Schweitzer A, et al. Optimized base editors enable efficient editing in cells, organoids and mice. Nat Biotechnol. 2018;36:888-893 pubmed publisher
	Dow L, Fisher J, O Rourke K, Muley A, Kastenhuber E, Livshits G, et al. Inducible in vivo genome editing with CRISPR-Cas9. Nat Biotechnol. 2015;33:390-394 pubmed publisher
	Gracanin A, Timmermans Sprang E, van Wolferen M, Rao N, Grizelj J, Vince S, et al. Ligand-independent canonical Wnt activity in canine mammary tumor cell lines associated with aberrant LEF1 expression. PLoS ONE. 2014;9:e98698 pubmed publisher

product information

Catalog Number :

MABC202

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-APC Antibody, clone FE9

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P25054

Host Name :

Mouse

Antigen :

APC

Clone :

FE9

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-APC Antibody, clone FE9

Cross Reactivity :

Human

Background :

Adenomatous polyposis coli protein (APC) is a ubiquitous multidomain protein that has a well documented role as a tumor suppressor. The mechanism of APC-mediated tumor suppression is still an area of active investigation; however, several studies suggest that APC is a negative regulator of the Wnt signaling pathway as it downregulates β-catenin via interactions with Axin/GSK3-β complex, thereby preventing transcription of genes such as MYC that contribute to cell proliferation. Defective APC proteins contribute to the initiation and proliferation of various types of cancers, including familial adenomatous polyposis. However, other studies have shown that APC interacts with a range of other proteins such as the EB1 microtubule-binding proteins, to regulate other processes such as cell migration.

ALT Names :

Adenomatous polyposis coli protein;Protein APC;Deleted in polyposis 2.5

Immunogen :

Linear peptide corresponding to the N-terminus of human APC.

Specificity :

This antibody recognizes the N-terminus of APC.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt