Isocitrate Dehydrogenase 1 (IDH1)-R132S Antibody, clone SMab-1 | EMD Millipore MABC187 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Isocitrate Dehydrogenase 1 (IDH1)-R132S Antibody, clone SMab-1

catalog :

MABC187

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

SMab-1

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

product information

Catalog Number :

MABC187

Subcategory :

Cell Structure

Product Name :

Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132S Antibody, clone SMab-1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O75874

Host Name :

Mouse

Antigen :

Isocitrate Dehydrogenase 1 (IDH1)-R132S

Clone :

Smab-1

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132S Antibody, clone SMab-1

Cross Reactivity :

Human

Background :

Isocitrate dehydrogenase 1 (IDH1) is a 46 kDa NADP-dependent enzyme, which catalyzes the decarboxylation of isocitrate into α-ketoglutarate. IDH1 may also play a role in the prevention of oxidative damage, and the shuttling of proteins to peroxisomes. It is widely reported that mutations in IDH1 result in multiple forms of gliomas. The Arginine to Serine substitution at amino acid 132 is seen in gliomas, abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate.

ALT Names :

Isocitrate dehydrogenase [NADP] cytoplasmic;IDH;Cytosolic NADP-isocitrate dehydrogenase;IDP;NADP(+)-specific ICDH;Oxalosuccinate decarboxylase

Immunogen :

KLH-conjugated linear peptide corresponding to human Isocitrate Dehydrogenase 1 (IDH1)-R132S.

Specificity :

This antibody only detects the R132S mutation of Isocitrate Dehydrogenase (IDH1).

Package Size :

100 µL

Uses :

Western Blotting;Immunocytochemistry;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt