Angiogenin Antibody, clone 26–2F (Azide Free) | EMD Millipore MABC166 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Angiogenin Antibody, clone 26–2F (Azide Free)

catalog :

MABC166

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

26-2F

The same clone is also sold as:

Absolute Antibody: Ab00400-10.0, Ab00400-1.1, Ab00400-1.4, Ab00400-10.3, Ab00400-23.0, Ab00400-10.7, Ab00400-23.3
Invitrogen: 14-9762-37, 14-9762-82, 14-9762-80

reactivity :

human

application :

immunohistochemistry, immunocytochemistry

product information

Catalog Number :

MABC166

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Angiogenin Antibody, clone 26–2F (Azide Free)

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P03950

Host Name :

Mouse

Antigen :

ANG

Clone :

26-2F

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-Angiogenin Antibody, clone 26–2F (Azide Free)

Cross Reactivity :

Human

Background :

Angiogenin (Ang) is a non-glycosylated polypeptide, 123 amino acids in length, with a molecular mass of 14 kDa. It is secreted by tumor cells and is a potent inducer of neovascularization. Angiogenin is produced by a variety of cell types including vascular endothelial cells and smooth muscle cells, fibroblasts, tumor colonic epithelium, normal peripheral blood lymphocytes, lung and colonic epithelial tumor cell lines, and primary gastrointestinal adenocarcinomas. It specifically binds to endothelial cells and elicits second messenger systems. Angiogenin is present in human follicular fluid, and its production is up-regulated by human chorionic gonadotropin and hypoxic conditions. Angiogenin shows a high degree of homology with known ribonucleases such as pancreatic ribonuclease A, and the capacity of angiogenin to induce blood vessel growth is dependent on its ribo-nucleolytic activity. Angiogenin is thought to be involved in the development of solid tumors; angiogenin antagonists are capable of inhibiting tumor growth. Angiogenin is endocytosed by subconfluent endothelial cells and translocated to the nucleus, where it accumulates in the nucleolus. Serum angiogenin concentration is increased in serum of colorectal cancer patients, and correlates with cancer progression. The cytoskeletal protein α-actinin-2 binds to angiogenin, which might be a novel interface target for anti-angiogenesis and anti-tumor therapy.

ALT Names :

Angiogenin, Ribonuclease 5, RNase 5

Immunogen :

Purified Human Angiogenin.

Package Size :

100 μg

Uses :

Immunocytochemistry, Inhibition, Immunohistochemistry

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.