Casper/c-FLIP Antibody, clone 17B12.1 | EMD Millipore MABC148 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Casper/c-FLIP Antibody, clone 17B12.1

catalog :

MABC148

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

17B12.1

reactivity :

human, rat

application :

western blot, immunohistochemistry

product information

Catalog Number :

MABC148

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Casper/c-FLIP Antibody, clone 17B12.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O15519

Host Name :

Mouse

Antigen :

Casper/c-FLIP

Clone :

17B12.1

Conjugate :

Purified

Isotype :

IgG2bκ

Product Description :

Anti-Casper/c-FLIP Antibody, clone 17B12.1

Cross Reactivity :

Rat;Human

Background :

Caspase-eight-related protein (Casper), also known as Cellular FLICE-like inhibitory protein (c-FLIP), CASP8, FADD-like apoptosis regulator (CFLAR), Caspase homolog (CASH), Caspase-like apoptosis regulatory protein (CLARP), FADD-like antiapoptotic molecule 1 (FLAME-1), Inhibitor of FLICE (I-FLICE), MACH-related inducer of toxicity (MRIT), and Usurpin. Casper shows a wide expression profile, with higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Casper is an apoptosis regulator and acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Casper lacks enzymatic activity.

ALT Names :

CASP8 and FADD-like apoptosis regulator;Caspase homolog;CASH;Caspase-eight-related protein;Casper;Caspase-like apoptosis regulatory protein;CLARP;Cellular FLICE-like inhibitory protein;c-FLIP;FADD-like antiapoptotic molecule 1;FLAME-1;Inhibitor of FLICE;I-FLICE;MACH-related inducer of toxicity;MRIT;Usurpin;2.CASP8 and FADD-like apoptosis regulator subunit p12;CASP8 and FADD-like apoptosis regulator subunit p43

Immunogen :

GST-tagged recombinant protein corresponding to human Casper/c-FLIP.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt