This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
Enterovirus 71 Antibody, cross-reacts with Coxsackie A16, clone 422-8D-4C-4D
catalog :
MAB979
quantity :
100 μL
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
422-8D-4C-4D
reactivity :
Enterovirus A71, human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
citations: 54
Published Application/Species/Sample/DilutionReference
  • western blot; Enterovirus A71; 1:1000; fig 2
Arthur Huang K, Chen M, Huang Y, Shih S, Chiu C, Lin J, et al. Epitope-associated and specificity-focused features of EV71-neutralizing antibody repertoires from plasmablasts of infected children. Nat Commun. 2017;8:762 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 3a
Yue Y, Li P, Song N, Li B, Li Z, Guo Y, et al. Genomic and immunologic factors associated with viral pathogenesis in a lethal EV71 infected neonatal mouse model. Mol Med Rep. 2016;13:4183-90 pubmed publisher
  • western blot; human; fig 3
Wang M, Dong Q, Wang H, He Y, Chen Y, Zhang H, et al. Oblongifolin M, an active compound isolated from a Chinese medical herb Garcinia oblongifolia, potently inhibits enterovirus 71 reproduction through downregulation of ERp57. Oncotarget. 2016;7:8797-808 pubmed publisher
  • western blot; human; loading ...; fig 1d
Li H, Zhang L, Zhu X, Shang J, Chen X, Zhu Y, et al. Analysis of EV71 infection progression using triple-SILAC-based proteomics approach. Proteomics. 2015;15:3629-43 pubmed publisher
  • western blot; Enterovirus A71; fig 1
Tsou Y, Lin Y, Shao H, Yu S, Wu S, Lin H, et al. Recombinant adeno-vaccine expressing enterovirus 71-like particles against hand, foot, and mouth disease. PLoS Negl Trop Dis. 2015;9:e0003692 pubmed publisher
  • immunohistochemistry; human
Yu P, Gao Z, Zong Y, Bao L, Xu L, Deng W, et al. Histopathological features and distribution of EV71 antigens and SCARB2 in human fatal cases and a mouse model of enterovirus 71 infection. Virus Res. 2014;189:121-32 pubmed publisher
Li C, Huang L, Sun W, Chen Y, He M, Yue J, et al. Saikosaponin D suppresses enterovirus A71 infection by inhibiting autophagy. Signal Transduct Target Ther. 2019;4:4 pubmed publisher
Chen K, Yu C, Kung S, Chen S, Chang C, Ho T, et al. Toll-Like Receptor 3 Is Involved in Detection of Enterovirus A71 Infection and Targeted by Viral 2A Protease. Viruses. 2018;10: pubmed publisher
Zhu J, Chen N, Zhou S, Zheng K, Sun L, Zhang Y, et al. Severity of enterovirus A71 infection in a human SCARB2 knock-in mouse model is dependent on infectious strain and route. Emerg Microbes Infect. 2018;7:205 pubmed publisher
Yeung M, Jia L, Yip C, Chan J, Teng J, Chan K, et al. Human tryptophanyl-tRNA synthetase is an IFN-γ-inducible entry factor for Enterovirus. J Clin Invest. 2018;128:5163-5177 pubmed publisher
Tseligka E, Sobo K, Stoppini L, Cagno V, Abdul F, Piuz I, et al. A VP1 mutation acquired during an enterovirus 71 disseminated infection confers heparan sulfate binding ability and modulates ex vivo tropism. PLoS Pathog. 2018;14:e1007190 pubmed publisher
Fujii K, Sudaka Y, Takashino A, Kobayashi K, Kataoka C, Suzuki T, et al. VP1 Amino Acid Residue 145 of Enterovirus 71 Is a Key Residue for Its Receptor Attachment and Resistance to Neutralizing Antibody during Cynomolgus Monkey Infection. J Virol. 2018;92: pubmed publisher
Yang X, Hu Z, Fan S, Zhang Q, Zhong Y, Guo D, et al. Picornavirus 2A protease regulates stress granule formation to facilitate viral translation. PLoS Pathog. 2018;14:e1006901 pubmed publisher
Huang S, Huang Y, Tsai H, Kuo P, Wang S, Liu C, et al. A Selective Bottleneck Shapes the Evolutionary Mutant Spectra of Enterovirus A71 during Viral Dissemination in Humans. J Virol. 2017;91: pubmed publisher
Lai J, Sam I, Verlhac P, Baguet J, Eskelinen E, Faure M, et al. 2BC Non-Structural Protein of Enterovirus A71 Interacts with SNARE Proteins to Trigger Autolysosome Formation. Viruses. 2017;9: pubmed publisher
Ang L, Too H, Tan E, Chow T, Shek P, Tham E, et al. Antiviral activity of Lactobacillus reuteri Protectis against Coxsackievirus A and Enterovirus 71 infection in human skeletal muscle and colon cell lines. Virol J. 2016;13:111 pubmed publisher
Wang X, Xiao X, Zhao M, Liu W, Pang L, Sun X, et al. EV71 virus-like particles produced by co-expression of capsid proteins in yeast cells elicit humoral protective response against EV71 lethal challenge. BMC Res Notes. 2016;9:42 pubmed publisher
Yen L, Liao J, Lee H, Chou W, Chen C, Lin Y, et al. The C Terminus of the Core β-Ladder Domain in Japanese Encephalitis Virus Nonstructural Protein 1 Is Flexible for Accommodation of Heterologous Epitope Fusion. J Virol. 2016;90:1178-89 pubmed publisher
Yuan S, Li G, Wang Y, Gao Q, Wang Y, Cui R, et al. Identification of Positively Charged Residues in Enterovirus 71 Capsid Protein VP1 Essential for Production of Infectious Particles. J Virol. 2016;90:741-52 pubmed publisher
Wu C, Lin Y, Kuo C, Liu W, Tai H, Pan C, et al. Inactivated Enterovirus 71 Vaccine Produced by 200-L Scale Serum-Free Microcarrier Bioreactor System Provides Cross-Protective Efficacy in Human SCARB2 Transgenic Mouse. PLoS ONE. 2015;10:e0136420 pubmed publisher
Liao Y, Wang S, Wang J, Yu C, Liu C. Norepinephrine and Epinephrine Enhanced the Infectivity of Enterovirus 71. PLoS ONE. 2015;10:e0135154 pubmed publisher
Leong S, Ong B, Chu J. The role of Misshapen NCK-related kinase (MINK), a novel Ste20 family kinase, in the IRES-mediated protein translation of human enterovirus 71. PLoS Pathog. 2015;11:e1004686 pubmed publisher
Lee P, Liu C, Ho T, Tsai Y, Lin C, Wang Y, et al. Enterovirus 71 virion-associated galectin-1 facilitates viral replication and stability. PLoS ONE. 2015;10:e0116278 pubmed publisher
Zhao H, Li H, Han J, Deng Y, Zhu S, Li X, et al. Novel recombinant chimeric virus-like particle is immunogenic and protective against both enterovirus 71 and coxsackievirus A16 in mice. Sci Rep. 2015;5:7878 pubmed publisher
Hung H, Shih S, Chang T, Fang M, Hsu J. The combination effects of licl and the active leflunomide metabolite, A771726, on viral-induced interleukin 6 production and EV-A71 replication. PLoS ONE. 2014;9:e111331 pubmed publisher
Hsiao H, Chou A, Lin S, Lien S, Liu C, Chong P, et al. Delivery of human EV71 receptors by adeno-associated virus increases EV71 infection-induced local inflammation in adult mice. Biomed Res Int. 2014;2014:878139 pubmed publisher
Lei X, Han N, Xiao X, Jin Q, He B, Wang J. Enterovirus 71 3C inhibits cytokine expression through cleavage of the TAK1/TAB1/TAB2/TAB3 complex. J Virol. 2014;88:9830-41 pubmed publisher
Kiener T, Jia Q, Meng T, Chow V, Kwang J. A novel universal neutralizing monoclonal antibody against enterovirus 71 that targets the highly conserved "knob" region of VP3 protein. PLoS Negl Trop Dis. 2014;8:e2895 pubmed publisher
Xu L, Huang K, Ho T, Liu C, Lee Y, Lin C, et al. Monoclonal antibodies for diagnosis of enterovirus 71. Monoclon Antib Immunodiagn Immunother. 2013;32:386-94 pubmed publisher
Zhang H, Cong H, Song L, Tien P. The nuclear protein Sam68 is redistributed to the cytoplasm and is involved in PI3K/Akt activation during EV71 infection. Virus Res. 2014;180:1-11 pubmed publisher
Hwa S, Lee Y, Brewoo J, Partidos C, Osorio J, Santangelo J. Preclinical evaluation of the immunogenicity and safety of an inactivated enterovirus 71 candidate vaccine. PLoS Negl Trop Dis. 2013;7:e2538 pubmed publisher
Lin H, Yang Y, Yu S, Hsiao K, Liu C, Sia C, et al. Caveolar endocytosis is required for human PSGL-1-mediated enterovirus 71 infection. J Virol. 2013;87:9064-76 pubmed publisher
Kuo R, Kao L, Lin S, Wang R, Shih S. MDA5 plays a crucial role in enterovirus 71 RNA-mediated IRF3 activation. PLoS ONE. 2013;8:e63431 pubmed publisher
Lin Y, Yu S, Shao H, Lin H, Liu C, Hsiao K, et al. Human SCARB2 transgenic mice as an infectious animal model for enterovirus 71. PLoS ONE. 2013;8:e57591 pubmed publisher
Xi X, Zhang X, Wang B, Wang T, Wang J, Huang H, et al. The interplays between autophagy and apoptosis induced by enterovirus 71. PLoS ONE. 2013;8:e56966 pubmed publisher
Shen F, Tsai C, Wang L, Chang K, Tung Y, Su I, et al. Enterovirus 71 infection increases expression of interferon-gamma-inducible protein 10 which protects mice by reducing viral burden in multiple tissues. J Gen Virol. 2013;94:1019-27 pubmed publisher
Chong P, Guo M, Lin F, Hsiao K, Weng S, Chou A, et al. Immunological and biochemical characterization of coxsackie virus A16 viral particles. PLoS ONE. 2012;7:e49973 pubmed publisher
Kirk K, Poh C, Fecondo J, Pourianfar H, Shaw J, Grollo L. Cross-reactive neutralizing antibody epitopes against Enterovirus 71 identified by an in silico approach. Vaccine. 2012;30:7105-10 pubmed publisher
Gong X, Zhou J, Zhu W, Liu N, Li J, Li L, et al. Excessive proinflammatory cytokine and chemokine responses of human monocyte-derived macrophages to enterovirus 71 infection. BMC Infect Dis. 2012;12:224 pubmed publisher
Cordey S, Petty T, Schibler M, Martinez Y, Gerlach D, Van Belle S, et al. Identification of site-specific adaptations conferring increased neural cell tropism during human enterovirus 71 infection. PLoS Pathog. 2012;8:e1002826 pubmed publisher
Su P, Liu Y, Chang H, Huang S, Wang Y, Yu C, et al. Cell surface sialylation affects binding of enterovirus 71 to rhabdomyosarcoma and neuroblastoma cells. BMC Microbiol. 2012;12:162 pubmed publisher
Yamayoshi S, Iizuka S, Yamashita T, Minagawa H, Mizuta K, Okamoto M, et al. Human SCARB2-dependent infection by coxsackievirus A7, A14, and A16 and enterovirus 71. J Virol. 2012;86:5686-96 pubmed publisher
Kiener T, Jia Q, Lim X, He F, Meng T, Chow V, et al. Characterization and specificity of the linear epitope of the enterovirus 71 VP2 protein. Virol J. 2012;9:55 pubmed publisher
Lin Y, Lin H, Tsou Y, Chitra E, Hsiao K, Shao H, et al. Human SCARB2-mediated entry and endocytosis of EV71. PLoS ONE. 2012;7:e30507 pubmed publisher
Yeh M, Wang S, Yu C, Lin K, Lei H, Su I, et al. A single nucleotide in stem loop II of 5'-untranslated region contributes to virulence of enterovirus 71 in mice. PLoS ONE. 2011;6:e27082 pubmed publisher
Liu C, Guo M, Lin F, Hsiao K, Chang K, Chou A, et al. Purification and characterization of enterovirus 71 viral particles produced from vero cells grown in a serum-free microcarrier bioreactor system. PLoS ONE. 2011;6:e20005 pubmed publisher
Yamayoshi S, Koike S. Identification of a human SCARB2 region that is important for enterovirus 71 binding and infection. J Virol. 2011;85:4937-46 pubmed publisher
Wong T, Huang H, Wang Y, Lee Y, Huang C, Yu C. Methylene blue-mediated photodynamic inactivation as a novel disinfectant of enterovirus 71. J Antimicrob Chemother. 2010;65:2176-82 pubmed publisher
Wang S, Chen I, Su L, Huang K, Lei H, Liu C. Enterovirus 71 infection of monocytes with antibody-dependent enhancement. Clin Vaccine Immunol. 2010;17:1517-23 pubmed publisher
Huang M, Chiang P, Luo S, Liou G, Lee M. Development of a high-throughput assay for measuring serum neutralizing antibody against enterovirus 71. J Virol Methods. 2010;165:42-5 pubmed publisher
Kung Y, Huang S, Kuo P, Kiang D, Ho M, Liu C, et al. Introduction of a strong temperature-sensitive phenotype into enterovirus 71 by altering an amino acid of virus 3D polymerase. Virology. 2010;396:1-9 pubmed publisher
Hsu Y, Liu Y, Lu W, Kung S. Visualizing and quantifying the differential cleavages of the eukaryotic translation initiation factors eIF4GI and eIF4GII in the enterovirus-infected cell. Biotechnol Bioeng. 2009;104:1142-52 pubmed publisher
Huang S, Chang C, Wang P, Tsai Y, Liu H. Enterovirus 71-induced autophagy detected in vitro and in vivo promotes viral replication. J Med Virol. 2009;81:1241-52 pubmed publisher
Wu T, Wang Y, Lee Y, Wang J, Liu C, Wang S, et al. Immunity to avirulent enterovirus 71 and coxsackie A16 virus protects against enterovirus 71 infection in mice. J Virol. 2007;81:10310-5 pubmed
product information
Catalog Number :
MAB979
Subcategory :
Infectious Diseases
Product Name :
Anti-Enterovirus 71 Antibody, cross-reacts with Coxsackie A16, clone 422-8D-4C-4D
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Host Name :
Mouse
Antigen :
Enterovirus 71
Clone :
422-8D-4C-4D
Conjugate :
Ascites
Isotype :
IgG1
Product Description :
Anti-Enterovirus 71 Antibody, cross-reacts with Coxsackie A16, clone 422-8D-4C-4D
Cross Reactivity :
Human
Specificity :
Reacts with Enterovirus 71. Neutralizes enterovirus 71 BrCr strain at a titer of less than 1:14.
Package Size :
100 μL
Uses :
Immunofluorescence
Storage :
Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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