Heat Shock Factor II Antibody, clone 3E2 | EMD Millipore MAB88079 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Heat Shock Factor II Antibody, clone 3E2

catalog :

MAB88079

quantity :

50 µg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

3E2

The same clone is also sold as:

Santa Cruz Biotechnology: sc-13517 X, sc-13517
BioLegend: 829301
Invitrogen: MA1-91597
StressMarq Biosciences: SMC-119D
Abnova: MAB2199
Rockland Immunochemicals: 200-501-F51
LifeSpan Biosciences: LS-C231064, LS-C231054, LS-C231060, LS-C231046, LS-C231057, LS-C231056, LS-C150374, LS-C231063, LS-C231048, LS-C231062, LS-C231059, LS-C231068, LS-C231053, LS-C231058, LS-C231049, LS-C231055

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation

product information

Catalog Number :

MAB88079

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-Heat Shock Factor II Antibody, clone 3E2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q03933

Host Name :

Rat

Antigen :

Heat Shock Factor II

Clone :

3E2

Conjugate :

Purified

Isotype :

IgG2a

Product Description :

Anti-Heat Shock Factor II Antibody, clone 3E2

Cross Reactivity :

Human;Mouse;Monkey

ALT Names :

HSFII

Immunogen :

Full length recombinant mouse HSF2 proteins (aa 1-517)

Specificity :

MAB88079 recognizes a protein of 70 kDa, identified as Heat Shock Factor 2 (HSF2). The synthesis of heat shock proteins is dependent on transcriptional and post-transcriptional control in eukaryotic cells. The regulation of heat shock gene transcription is mediated by the transcriptional activator, Heat Shock Factor (HSF), which binds to heat shock response elements (HSEs). At least three HSFs have been isolated from the human, mouse, chicken, and tomato genomes and an additional factor, HSF4 has been identified in humans. HSFs purified from yeast, Drosphila, and human have different molecular weights and do not cross-react immunologically. These factors are activated by distinct stimuli. HSF1 responds to cellular stress signals such as heat, heavy metals, and oxidative reagents whereas, the HSF2 is activated during differentiation. some laboratories have reported that the constitutive, non-DNA binding, monomeric form of inactive HSF1 is located in the cytoplasm. Upon activation, HSF1 is trimerized and is localized in nucleus where it binds DNA. the phosphorylation of HSF1 may be necessary for maximal transcription of heat shock genes.

Package Size :

50 µg

Uses :

ELISA;Immunofluorescence;Immunoprecipitation;Western Blotting

Storage :

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.