Papillomavirus Antibody, 16, 18 E6 protein, clone C1P5 | EMD Millipore MAB874 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Papillomavirus Antibody, 16, 18 E6 protein, clone C1P5

catalog :

MAB874

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

C1P5

application :

western blot, immunohistochemistry

citations: 2

Reference
Sima N, Cheng X, Ye F, Ma D, Xie X, Lu W. The overexpression of scaffolding protein NEDD9 promotes migration and invasion in cervical cancer via tyrosine phosphorylated FAK and SRC. PLoS ONE. 2013;8:e74594 pubmed publisher
Luevano M, Bernard H, Barrera Saldaña H, Trevino V, Garcia Carranca A, Villa L, et al. High-throughput profiling of the humoral immune responses against thirteen human papillomavirus types by proteome microarrays. Virology. 2010;405:31-40 pubmed publisher

product information

Catalog Number :

MAB874

Subcategory :

Infectious Diseases

Product Name :

Anti-Papillomavirus Antibody, 16, 18 E6 protein, clone C1P5

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Host Name :

Mouse

Antigen :

Papillomavirus

Clone :

C1P5

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-Papillomavirus Antibody, 16, 18 E6 protein, clone C1P5

Cross Reactivity :

Human

Background :

Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.

ALT Names :

HPV

Immunogen :

C1P5 was made against HPV type 18 E6 protein produced in bacteria.

Specificity :

Recognizes Human papilloma virus type 18 early E6 protein. The antibody cross reacts with E6 protein from HPV type 16.

Package Size :

100 μg

Uses :

Immunohistochemistry;Western Blotting

Storage :

Maintain for 1 year at 2–8°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.