Cytomegalovirus Antibody, clone 8B1.2 | EMD Millipore MAB810R-500UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Cytomegalovirus Antibody, clone 8B1.2

catalog :

MAB810R-500UG

quantity :

500 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8B1.2

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 14

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human immunocytochemistry; human	Eifler M, Uecker R, Weisbach H, Bogdanow B, Richter E, KÃ¶nig L, et al. PUL21a-Cyclin A2 interaction is required to protect human cytomegalovirus-infected cells from the deleterious consequences of mitotic entry. PLoS Pathog. 2014;10:e1004514 pubmed publisher
	Esteso G, Luzón E, Sarmiento E, Gómez Caro R, Steinle A, Murphy G, et al. Altered microRNA expression after infection with human cytomegalovirus leads to TIMP3 downregulation and increased shedding of metalloprotease substrates, including MICA. J Immunol. 2014;193:1344-52 pubmed publisher
	Yan Z, Wang L, Dennis J, Doern C, Baker J, Park J. Clinical significance of isolated cytomegalovirus-infected gastrointestinal cells. Int J Surg Pathol. 2014;22:492-8 pubmed publisher
	Wiebusch L, Hagemeier C. Use of 5-ethynyl-2'-deoxyuridine labelling and flow cytometry to study cell cycle-dependent regulation of human cytomegalovirus gene expression. Methods Mol Biol. 2014;1119:123-32 pubmed publisher
	Pereira L, Petitt M, Fong A, Tsuge M, Tabata T, Fang Hoover J, et al. Intrauterine growth restriction caused by underlying congenital cytomegalovirus infection. J Infect Dis. 2014;209:1573-84 pubmed publisher
	Yaiw K, Ovchinnikova O, Taher C, Mohammad A, Davoudi B, Shlyakhto E, et al. High prevalence of human cytomegalovirus in carotid atherosclerotic plaques obtained from Russian patients undergoing carotid endarterectomy. Herpesviridae. 2013;4:3 pubmed publisher
	Djaoud Z, David G, Bressollette C, Willem C, Rettman P, Gagne K, et al. Amplified NKG2C+ NK cells in cytomegalovirus (CMV) infection preferentially express killer cell Ig-like receptor 2DL: functional impact in controlling CMV-infected dendritic cells. J Immunol. 2013;191:2708-16 pubmed publisher
	Omoto S, Mocarski E. Cytomegalovirus UL91 is essential for transcription of viral true late (?2) genes. J Virol. 2013;87:8651-64 pubmed publisher
	Melnick M, Sedghizadeh P, Allen C, Jaskoll T. Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship. Exp Mol Pathol. 2012;92:118-25 pubmed publisher
	Ehlinger E, Webster E, Kang H, Cangialose A, Simmons A, Barbas K, et al. Maternal cytomegalovirus-specific immune responses and symptomatic postnatal cytomegalovirus transmission in very low-birth-weight preterm infants. J Infect Dis. 2011;204:1672-82 pubmed publisher
	Ahlqvist J, Mocarski E. Cytomegalovirus UL103 controls virion and dense body egress. J Virol. 2011;85:5125-35 pubmed publisher
	Lucas K, Bao L, Bruggeman R, Dunham K, Specht C. The detection of CMV pp65 and IE1 in glioblastoma multiforme. J Neurooncol. 2011;103:231-8 pubmed publisher
	Millard A, Haberli L, Sinzger C, Ghielmetti M, Schneider M, Bossart W, et al. Efficiency of porcine endothelial cell infection with human cytomegalovirus depends on both virus tropism and endothelial cell vascular origin. Xenotransplantation. 2010;17:274-87 pubmed publisher
	Chen I, Lai Y, Wu C, Chang Y, Chu C, Tsai I, et al. Immune impairment in patients with terminal cancers: influence of cancer treatments and cytomegalovirus infection. Cancer Immunol Immunother. 2010;59:323-34 pubmed publisher

product information

Catalog Number :

MAB810R-500UG

Subcategory :

Infectious Diseases

Product Name :

Anti-Cytomegalovirus Antibody, clone 8B1.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Host Name :

Mouse

Antigen :

Cytomegalovirus

Clone :

8B1.2

Conjugate :

Purified

Isotype :

IgG2a

Product Description :

Anti-Cytomegalovirus Antibody, clone 8B1.2

Cross Reactivity :

Human

Background :

Human cytomegalovirus (HCMV) is a ubiquitous human pathogen that belongs to the herpes adenovirus family. The viral life cycle takes approximately seventy two hours. After the initial fusion of the viral envelope with the plasma membrane of the cell, the encapisidated virus particle is released into the cytoplasm and within minutes, transits to the nucleus. Via active transport through the nuclear pore, the capsid gains entry and viral DNA is deposited. Viral gene expression then occurs in a temporally regulated manner, first with expression of the immediate early genes, followed by the early genes, then, after viral replication has commenced, the late genes. All of the immediate early proteins have been shown to be transactivators, with IE1-72 and IE2-86 being the most well characterized. These genes regulate the expression of factors required for virus replication.

ALT Names :

CMV

Immunogen :

Affinity purified immediate early antigen from MRC-5 cells infected with CMV AD169 (ATCC).

Specificity :

Reacts with an immediate early non-structural antigen of 68-72 kDa. This antigen can be detected 1 hour after infection exhibiting an intranuclear staining pattern. This staining reaches a peak at 10-12 hours. This antigen persists and can be detected throughout the complete CMV infection cycle.

Package Size :

500 µg

Uses :

ELISA;Flow Cytometry;Immunofluorescence;Immunohistochemistry (Paraffin);Western Blotting

Storage :

Maintain for 1 year at 2–8°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.