Myelin Oligodendrocyte Glycoprotein (MOG) Antibody | EMD Millipore MAB5680 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Myelin Oligodendrocyte Glycoprotein (MOG) Antibody

catalog :

MAB5680

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8-18C5

reactivity :

human, mouse, rat, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section

citations: 18

Published Application/Species/Sample/Dilution	Reference
western blot; rat; 1:5000; loading ...; fig 1a western blot; mouse; 1:5000; loading ...; fig 4a	Zhou L, Shao C, Xie Y, Wang N, Xu S, Luo B, et al. Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination. elife. 2020;9: pubmed publisher
immunohistochemistry; mouse; 1:100; loading ...; fig 4a, 4b, 4c, 4d	Marion C, McDaniel D, Armstrong R. Sarm1 deletion reduces axon damage, demyelination, and white matter atrophy after experimental traumatic brain injury. Exp Neurol. 2019;321:113040 pubmed publisher
immunohistochemistry - frozen section; human; 1:1000; loading ...; fig 3a	Schirmer L, Velmeshev D, Holmqvist S, Kaufmann M, Werneburg S, Jung D, et al. Neuronal vulnerability and multilineage diversity in multiple sclerosis. Nature. 2019;573:75-82 pubmed publisher
immunocytochemistry; rat; 1:500; loading ...; fig 5b	Stojic A, Bojcevski J, Williams S, Bas Orth C, Nessler S, Linington C, et al. Preclinical stress originates in the rat optic nerve head during development of autoimmune optic neuritis. Glia. 2019;67:512-524 pubmed publisher
immunohistochemistry - frozen section; human; 1:1000	Liddelow S, Guttenplan K, Clarke L, Bennett F, Bohlen C, Schirmer L, et al. Neurotoxic reactive astrocytes are induced by activated microglia. Nature. 2017;541:481-487 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:500; fig 3	Dooves S, Bugiani M, Postma N, Polder E, Land N, Horan S, et al. Astrocytes are central in the pathomechanisms of vanishing white matter. J Clin Invest. 2016;126:1512-24 pubmed publisher
flow cytometry; human; fig 1b	van Nierop G, Janssen M, Mitterreiter J, van de Vijver D, De Swart R, Haagmans B, et al. Intrathecal CD4(+) and CD8(+) T-cell responses to endogenously synthesized candidate disease-associated human autoantigens in multiple sclerosis patients. Eur J Immunol. 2016;46:347-53 pubmed publisher
immunocytochemistry; rat; 1:1000	GÃ¶ttle P, Sabo J, Heinen A, Venables G, Torres K, Tzekova N, et al. Oligodendroglial maturation is dependent on intracellular protein shuttling. J Neurosci. 2015;35:906-19 pubmed publisher
immunohistochemistry - frozen section; human; 1:200	Schirmer L, Srivastava R, Kalluri S, Böttinger S, Herwerth M, Carassiti D, et al. Differential loss of KIR4.1 immunoreactivity in multiple sclerosis lesions. Ann Neurol. 2014;75:810-28 pubmed publisher
	Sullivan G, Knutsen A, Peruzzotti Jametti L, Korotcov A, Bosomtwi A, Dardzinski B, et al. Transplantation of induced neural stem cells (iNSCs) into chronically demyelinated corpus callosum ameliorates motor deficits. Acta Neuropathol Commun. 2020;8:84 pubmed publisher
	Sánchez M, Sullivan G, Armstrong R. Genetic detection of Sonic hedgehog (Shh) expression and cellular response in the progression of acute through chronic demyelination and remyelination. Neurobiol Dis. 2018;115:145-156 pubmed publisher
	Xu D, Robinson A, Ishii T, Duncan D, Alden T, Goings G, et al. Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy. J Exp Med. 2018;215:1169-1186 pubmed publisher
	Sánchez M, Armstrong R. Postnatal Sonic hedgehog (Shh) responsive cells give rise to oligodendrocyte lineage cells during myelination and in adulthood contribute to remyelination. Exp Neurol. 2018;299:122-136 pubmed publisher
	Davidson N, Yu F, Kijpaisalratana N, Le T, Beer L, Radomski K, et al. Leukemia/lymphoma-related factor (LRF) exhibits stage- and context-dependent transcriptional controls in the oligodendrocyte lineage and modulates remyelination. J Neurosci Res. 2017;95:2391-2408 pubmed publisher
	Pritchard A, Mir A, Dev K. Fingolimod attenuates splenocyte-induced demyelination in cerebellar slice cultures. PLoS ONE. 2014;9:e99444 pubmed publisher
	Nakatani H, Martin E, Hassani H, Clavairoly A, Maire C, Viadieu A, et al. Ascl1/Mash1 promotes brain oligodendrogenesis during myelination and remyelination. J Neurosci. 2013;33:9752-9768 pubmed publisher
	Najm F, Lager A, Zaremba A, Wyatt K, Caprariello A, Factor D, et al. Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells. Nat Biotechnol. 2013;31:426-33 pubmed publisher
	Bernard F, Moreau Fauvarque C, Heitz Marchaland C, Zagar Y, Dumas L, Fouquet S, et al. Role of transmembrane semaphorin Sema6A in oligodendrocyte differentiation and myelination. Glia. 2012;60:1590-604 pubmed publisher

product information

Catalog Number :

MAB5680

Subcategory :

Neuroscience

Product Name :

Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q63345

Host Name :

Mouse

Antigen :

Myelin Oligodendrocyte Glycoprotein (MOG)

Clone :

8-18C5

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody

Cross Reactivity :

Mouse;Rat

Background :

Myelin oligodendrocyte glycoprotein (MOG) is a key CNS-specific autoantigen for primary demyelination in multiple sclerosis. Although the disease-inducing role of MOG has been established, its precise function in the CNS remains obscure. MOG is a type I integral membrane protein possessing a single extracellular Ig variable domain (Ig-V) (3, 13, 14). The amino acid sequence of MOG is highly conserved among animal species ( 90%), indicative of an important biological function. MOG is specifically expressed in the CNS on the outermost lamellae of the myelin sheath as well as the cell body and processes of oligodendrocytes. The developmentally late expression of MOG correlates with the later stages of myelinogenesis, suggesting that MOG has a role in the completion, compaction, and/or maintenance of myelin, further suggesting that MOG has an adhesive function within the CNS . Consistent with MOG's possible adhesive role in the CNS, a homodimeric form of MOG has not only been observed after isolation from the CNS but has additionally been observed in situ.

ALT Names :

MOG

Immunogen :

Rat cerebellar glycoproteins

Specificity :

Membane associated region of MOG [Myelin oligodendrocyte glycoprotein].

Package Size :

100 μg

Uses :

Flow Cytometry;Immunocytochemistry;Immunohistochemistry;Western Blotting

Storage :

Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.