HCN1 Antibody, clone RQT 7C3 | EMD Millipore MAB5594 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

HCN1 Antibody, clone RQT 7C3

catalog :

MAB5594

quantity :

100 µL

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

RQT 7C3

reactivity :

mouse, rat

application :

western blot, immunohistochemistry

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; rat; 1:4000	Cain S, Tyson J, Jones K, Snutch T. Thalamocortical neurons display suppressed burst-firing due to an enhanced Ih current in a genetic model of absence epilepsy. Pflugers Arch. 2015;467:1367-82 pubmed publisher

product information

Catalog Number :

MAB5594

Subcategory :

Neuroscience

Product Name :

Anti-HCN1 Antibody, clone RQT 7C3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9JKB0

Host Name :

Rat

Antigen :

HCN1

Clone :

RQT 7C3

Conjugate :

Ascites

Isotype :

IgG1

Product Description :

Anti-HCN1 Antibody, clone RQT 7C3

Cross Reactivity :

Mouse;Rat

Background :

HCN1 and HCN2 play an important role for motor learning and synapse formation by integration of cerebellar Purkinje cells; as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. HCN1 expression is high in the cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. Hyperpolarization activated cation channels of the HCN gene family such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain. HCN1 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN channels pass both Na+ and K+ with relative permeability ratio of ~0.15 to 0.25. The primary sequence of HCN pore region is clearly related to that of highly selective K+ channels. In contrast to nonselective CNG or Na+-channels, both K+ and HCN channels contain a GYG motif in the pore.

ALT Names :

Hyperpolarization-activated and cyclic nucleotide-gated channel 1

Immunogen :

Synthetic peptide from rat HCN1.

Specificity :

HCN1 (Hyperpolarization-activated and cyclic nucleotide-gated channel 1). The antibody recognizes both the glycosyated and deglycosylated form of HCN1.

Package Size :

100 µL

Uses :

Immunohistochemistry;Western Blotting

Storage :

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.