This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
Parkin Antibody, clone PRK8
catalog :
MAB5512
quantity :
100 µL
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
PRK8

The same clone is also sold as:
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 13
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; loading ...; fig 4a
Bertolin G, Jacoupy M, Traver S, Ferrando Miguel R, Saint Georges T, Grenier K, et al. Parkin maintains mitochondrial levels of the protective Parkinson's disease-related enzyme 17-β hydroxysteroid dehydrogenase type 10. Cell Death Differ. 2015;22:1563-76 pubmed publisher
  • western blot; mouse
Mandemakers W, Abuhatzira L, Xu H, Caromile L, Hébert S, Snellinx A, et al. Co-regulation of intragenic microRNA miR-153 and its host gene Ia-2 ?: identification of miR-153 target genes with functions related to IA-2? in pancreas and brain. Diabetologia. 2013;56:1547-56 pubmed publisher
Scuderi S, La Cognata V, Drago F, Cavallaro S, D Agata V. Alternative splicing generates different parkin protein isoforms: evidences in human, rat, and mouse brain. Biomed Res Int. 2014;2014:690796 pubmed publisher
Dave K, De Silva S, Sheth N, Ramboz S, Beck M, Quang C, et al. Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease. Neurobiol Dis. 2014;70:190-203 pubmed publisher
Sunico C, Nakamura T, Rockenstein E, Mante M, Adame A, Chan S, et al. S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's disease. Mol Neurodegener. 2013;8:29 pubmed publisher
Viotti J, Duplan E, Caillava C, Condat J, Goiran T, Giordano C, et al. Glioma tumor grade correlates with parkin depletion in mutant p53-linked tumors and results from loss of function of p53 transcriptional activity. Oncogene. 2014;33:1764-75 pubmed publisher
Dettmer U, Newman A, Luth E, Bartels T, Selkoe D. In vivo cross-linking reveals principally oligomeric forms of ?-synuclein and ?-synuclein in neurons and non-neural cells. J Biol Chem. 2013;288:6371-85 pubmed publisher
Van Humbeeck C, Cornelissen T, Hofkens H, Mandemakers W, Gevaert K, De Strooper B, et al. Parkin interacts with Ambra1 to induce mitophagy. J Neurosci. 2011;31:10249-61 pubmed publisher
Bouman L, Schlierf A, Lutz A, Shan J, Deinlein A, Kast J, et al. Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress. Cell Death Differ. 2011;18:769-82 pubmed publisher
Tai H, Besche H, Goldberg A, Schuman E. Characterization of the Brain 26S Proteasome and its Interacting Proteins. Front Mol Neurosci. 2010;3: pubmed publisher
Fournier M, Vitte J, Garrigue J, Langui D, Dullin J, Saurini F, et al. Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. PLoS ONE. 2009;4:e6629 pubmed publisher
Lutz A, Exner N, Fett M, Schlehe J, Kloos K, Lämmermann K, et al. Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. J Biol Chem. 2009;284:22938-51 pubmed publisher
Huynh D, Nguyen D, Pulst Korenberg J, Brice A, Pulst S. Parkin is an E3 ubiquitin-ligase for normal and mutant ataxin-2 and prevents ataxin-2-induced cell death. Exp Neurol. 2007;203:531-41 pubmed
product information
Catalog Number :
MAB5512
Subcategory :
Neuroscience
Product Name :
Anti-Parkin Antibody, clone PRK8
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Gene ID :
O60260
Host Name :
Mouse
Antigen :
Parkin
Clone :
PRK8
Conjugate :
Ascites
Isotype :
IgG2b
Product Description :
Anti-Parkin Antibody, clone PRK8
Cross Reactivity :
Human;Mouse
Immunogen :
Recombinant human parkin.
Specificity :
Parkin. The epitope recognizes by the monoclonal is between animo acids 399-465 of human parkin. The antibody shows no cross-reactivity with protein in extracts from parkin null mice.
Package Size :
100 µL
Uses :
Immunoprecipitation;Western Blotting;Immunohistochemistry
Storage :
Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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