Huntingtin Antibody, a.a. 115-129 | EMD Millipore MAB5490 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Huntingtin Antibody, a.a. 115-129

catalog :

MAB5490

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation

citations: 9

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:500	O Brien R, DeGiacomo F, Holcomb J, Bonner A, Ring K, Zhang N, et al. Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo. J Biol Chem. 2015;290:19287-306 pubmed publisher
immunoprecipitation; human western blot; human	O Rourke J, Gareau J, Ochaba J, Song W, Rasko T, Reverter D, et al. SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation. Cell Rep. 2013;4:362-75 pubmed publisher
	Sapp E, Valencia A, Li X, Aronin N, Kegel K, Vonsattel J, et al. Native mutant huntingtin in human brain: evidence for prevalence of full-length monomer. J Biol Chem. 2012;287:13487-99 pubmed publisher
	Grison A, Mantovani F, Comel A, Agostoni E, Gustincich S, Persichetti F, et al. Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin. Proc Natl Acad Sci U S A. 2011;108:17979-84 pubmed publisher
	Zucchelli S, Marcuzzi F, Codrich M, Agostoni E, Vilotti S, Biagioli M, et al. Tumor necrosis factor receptor-associated factor 6 (TRAF6) associates with huntingtin protein and promotes its atypical ubiquitination to enhance aggregate formation. J Biol Chem. 2011;286:25108-17 pubmed publisher
	Juenemann K, Weisse C, Reichmann D, Kaether C, Calkhoven C, Schilling G. Modulation of mutant huntingtin N-terminal cleavage and its effect on aggregation and cell death. Neurotox Res. 2011;20:120-33 pubmed publisher
	Thompson L, Aiken C, Kaltenbach L, Agrawal N, Illes K, Khoshnan A, et al. IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J Cell Biol. 2009;187:1083-99 pubmed publisher
	Ratovitski T, Nakamura M, D Ambola J, Chighladze E, Liang Y, Wang W, et al. N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington's disease. Cell Cycle. 2007;6:2970-81 pubmed
	Schilling G, Klevytska A, Tebbenkamp A, Juenemann K, Cooper J, Gonzales V, et al. Characterization of huntingtin pathologic fragments in human Huntington disease, transgenic mice, and cell models. J Neuropathol Exp Neurol. 2007;66:313-20 pubmed

product information

Catalog Number :

MAB5490

Subcategory :

Neuroscience

Product Name :

Anti-Huntingtin Antibody, a.a. 115-129

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P42858

Host Name :

Mouse

Antigen :

Huntingtin

Conjugate :

Ascites

Isotype :

IgG1κ

Product Description :

Anti-Huntingtin Antibody, a.a. 115-129

Cross Reactivity :

Human

Immunogen :

Recombinant human huntingtin, amino acids 115-129.

Specificity :

Reacts huntingtin protein, amino acids 115-129. The antibody recognizes wild type and mutant huntingtin.

Package Size :

100 µL

Uses :

ELISA;Western Blotting;Immunocytochemistry;Immunohistochemistry

Storage :

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.