Indoleamine 2,3-dioxygenase Antibody, clone 10.1 | EMD Millipore MAB5412 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Indoleamine 2,3-dioxygenase Antibody, clone 10.1

catalog :

MAB5412

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

10.1

The same clone is also sold as:

MilliporeSigma: SAB3701446
Rockland Immunochemicals: 200-301-E57
LifeSpan Biosciences: LS-C153780
Bio-Rad: OBT2037G
OriGene: AM01159PU-N, TA319542

reactivity :

human, mouse

application :

western blot, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 18

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:50; loading ...; fig 5a western blot; human; 1:500; fig 1c	Maliniemi P, Laukkanen K, Väkevä L, Dettmer K, Lipsanen T, Jeskanen L, et al. Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas. Oncoimmunology. 2017;6:e1273310 pubmed publisher
western blot; human; fig 1b	Romani L, Oikonomou V, Moretti S, Iannitti R, D Adamo M, Villella V, et al. Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis. Nat Med. 2017;23:590-600 pubmed publisher
immunohistochemistry - paraffin section; human; 1:25; fig 2b	Friedman K, Brodsky A, Lu S, Wood S, Gill A, Lombardo K, et al. Medullary carcinoma of the colon: a distinct morphology reveals a distinctive immunoregulatory microenvironment. Mod Pathol. 2016;29:528-41 pubmed publisher
western blot; human; 1:250	Brito R, Malta C, Souza D, Matheus L, Matos Y, Silva C, et al. 1-Methyl-D-tryptophan potentiates TGF-Î²-induced epithelial-mesenchymal transition in T24 human bladder cancer cells. PLoS ONE. 2015;10:e0134858 pubmed publisher
flow cytometry; human	Ajamian F, Wu Y, Ebeling C, Ilarraza R, Odemuyiwa S, Moqbel R, et al. Respiratory syncytial virus induces indoleamine 2,3-dioxygenase activity: a potential novel role in the development of allergic disease. Clin Exp Allergy. 2015;45:644-59 pubmed publisher
immunohistochemistry - paraffin section; human; 1:50	Jitschin R, Braun M, Büttner M, Dettmer Wilde K, Bricks J, Berger J, et al. CLL-cells induce IDOhi CD14+HLA-DRlo myeloid-derived suppressor cells that inhibit T-cell responses and promote TRegs. Blood. 2014;124:750-60 pubmed publisher
	Matheus L, Simão G, Amaral T, Brito R, Malta C, Matos Y, et al. Indoleamine 2, 3-dioxygenase (IDO) increases during renal fibrogenesis and its inhibition potentiates TGF-β 1-induced epithelial to mesenchymal transition. BMC Nephrol. 2017;18:287 pubmed publisher
	Zong S, Li C, Luo C, Zhao X, Liu C, Wang K, et al. Dysregulated expression of IDO may cause unexplained recurrent spontaneous abortion through suppression of trophoblast cell proliferation and migration. Sci Rep. 2016;6:19916 pubmed publisher
	Carbotti G, Barisione G, Airoldi I, Mezzanzanica D, Bagnoli M, Ferrero S, et al. IL-27 induces the expression of IDO and PD-L1 in human cancer cells. Oncotarget. 2015;6:43267-80 pubmed publisher
	Maliniemi P, Hahtola S, Ovaska K, Jeskanen L, VÃ¤kevÃ¤ L, JÃ¤ntti K, et al. Molecular characterization of subcutaneous panniculitis-like T-cell lymphoma reveals upregulation of immunosuppression- and autoimmunity-associated genes. Orphanet J Rare Dis. 2014;9:160 pubmed publisher
	Luukkainen A, Karjalainen J, Honkanen T, Lehtonen M, Paavonen T, Toppila Salmi S. Indoleamine 2,3-dioxygenase expression in patients with allergic rhinitis: a case-control study. Clin Transl Allergy. 2011;1:17 pubmed publisher
	Gupta N, Thaker A, Kanuri N, Riehl T, Rowley C, Stenson W, et al. Serum analysis of tryptophan catabolism pathway: correlation with Crohn's disease activity. Inflamm Bowel Dis. 2012;18:1214-20 pubmed publisher
	Seow W, Yang Y, George A. Oligopeptide-mediated gene transfer into mouse corneal endothelial cells: expression, design optimization, uptake mechanism and nuclear localization. Nucleic Acids Res. 2009;37:6276-89 pubmed publisher
	Serbecic N, Lahdou I, Scheuerle A, Hoftberger R, Aboul Enein F. Function of the tryptophan metabolite, L-kynurenine, in human corneal endothelial cells. Mol Vis. 2009;15:1312-24 pubmed
	Batista C, Juhasz C, Muzik O, Kupsky W, Barger G, Chugani H, et al. Imaging correlates of differential expression of indoleamine 2,3-dioxygenase in human brain tumors. Mol Imaging Biol. 2009;11:460-6 pubmed publisher
	Zheng X, Koropatnick J, Li M, Zhang X, Ling F, Ren X, et al. Reinstalling antitumor immunity by inhibiting tumor-derived immunosuppressive molecule IDO through RNA interference. J Immunol. 2006;177:5639-46 pubmed
	Beutelspacher S, Pillai R, Watson M, Tan P, Tsang J, McClure M, et al. Function of indoleamine 2,3-dioxygenase in corneal allograft rejection and prolongation of allograft survival by over-expression. Eur J Immunol. 2006;36:690-700 pubmed
	Serbecic N, Beutelspacher S. Indoleamine 2,3-dioxygenase protects corneal endothelial cells from UV mediated damage. Exp Eye Res. 2006;82:416-26 pubmed

product information

Catalog Number :

MAB5412

Subcategory :

Inflammation & Immunology

Product Name :

Anti-Indoleamine 2,3-dioxygenase Antibody, clone 10.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P14902

Host Name :

Mouse

Antigen :

Indoleamine 2

Clone :

10.1

Conjugate :

Purified

Isotype :

IgG3

Product Description :

Anti-Indoleamine 2,3-dioxygenase Antibody, clone 10.1

Cross Reactivity :

Human;Mouse

Background :

Indoleamine 2,3-dioxygenase (IDO) is an enzyme that is responsible for converting tryptophan to kynurenines. IDO is expressed by a wide variety of tissues and IDO can be upregulated by interferon gamma. IDO modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO may be involved in the suppression of the immune response to tumours and blocking the IDO pathway may be a potential target for immunotherapy.

ALT Names :

Indoleamine-pyrrole 2,3-dioxygenase

Immunogen :

Amino acids 78-184 of human IDO fused to GST.

Package Size :

100 µg

Uses :

Immunohistochemistry;Western Blotting

Storage :

Stable for 6 months at 2-8ºC in undiluted aliquots from date of receipt.