Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor® 488 | EMD Millipore MAB5386X product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor® 488

catalog :

MAB5386X

quantity :

50 µg

clonality :

monoclonal

host :

mouse

conjugate :

AF488

clone name :

ME20.4

The same clone is also sold as:

MilliporeSigma: N5408
LifeSpan Biosciences: LS-C348103, LS-C94279, LS-C348105, LS-C348104, LS-C348102, LS-C348263
Santa Cruz Biotechnology: sc-13577 AC, sc-13577
Invitrogen: 14-9400-80, MA1-18418, 17-9400-41, 12-9400-42, 53-9400-41, 17-9400-42, 12-9400-41, 14-9400-95, MA1-18420, 63-9400-42, 14-9400-82, 14-9400-37, MA1-20167, MA5-28522, 62-9400-42, 53-9400-42
OriGene: AM31842FC-N, AM31842AC-N, AM31842RP-N, AM31842BT-N, AM31842PU-N
Abnova: MAB5598, MAB5596
BioLegend: 345126, 345120, 345115, 345113, 345101, 345129, 345110, 345117, 345106, 345105, 345112, 345102, 345104, 345118, 345109, 345123, 345127, 345111, 345125, 345116, 345103, 345114, 345119, 345107, 345108, 345122

reactivity :

human

application :

immunocytochemistry, flow cytometry

citations: 2

Reference
Walsh E, Kim R, Del Valle L, Weaver M, Sheffield J, Lazarovici P, et al. Importance of interaction between nerve growth factor and ?9?1 integrin in glial tumor angiogenesis. Neuro Oncol. 2012;14:890-901 pubmed publisher
Rogers M, Bailey S, Matusica D, Nicholson I, Muyderman H, Pagadala P, et al. ProNGF mediates death of Natural Killer cells through activation of the p75NTR-sortilin complex. J Neuroimmunol. 2010;226:93-103 pubmed publisher

product information

Catalog Number :

MAB5386X

Subcategory :

Neuroscience

Product Name :

Anti-Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor® 488

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P08138

Host Name :

Mouse

Antigen :

Nerve Growth Factor Receptor

Clone :

ME20.4

Conjugate :

AlexaFluor®488

Isotype :

IgG1

Product Description :

Anti-Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor® 488

Cross Reactivity :

Human;Pig;Rabbit;Sheep

Background :

The low affinity NGFR (Nerve growth factor receptor) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NGFR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death. It is expressed on many neuronal cells types including many embryonic forms and the receptor can be used to isolate neuronal progenitor cells

Immunogen :

Human melanoma cell line.

Specificity :

Reacts with the low affinity nerve growth factor receptor (NGFR p75). The epitope recognized by the antibody maps within the third or fourth cysteine-rich repeats of the NGFR molecule. Reactivity has not been observed with rat, chicken, or mouse NGFR.

Package Size :

50 µg

Uses :

Flow Cytometry;Immunocytochemistry

Storage :

Aliquot and store at -20 ºC, or glycerol (ASC grade or better) can be added (1:1) and the antibody stored at -20ºC for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.