Nerve Growth Factor Receptor (p75) Antibody, clone ME20.4 | EMD Millipore MAB5386 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Nerve Growth Factor Receptor (p75) Antibody, clone ME20.4

catalog :

MAB5386

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

ME20.4

The same clone is also sold as:

BioLegend: 345108, 345125, 345118, 345102, 345110, 345117, 345120, 345116, 345119, 345104, 345106, 345127, 345101, 345123, 345109, 345107, 345114, 345129, 345103, 345113, 345126, 345105, 345122, 345111, 345115, 345112
MilliporeSigma: N5408
OriGene: AM31842RP-N, AM31842PU-N, AM31842BT-N, AM31842FC-N, AM31842AC-N
Invitrogen: 14-9400-37, 17-9400-42, 14-9400-80, MA1-18418, 53-9400-42, 14-9400-95, 12-9400-41, 12-9400-42, 53-9400-41, 62-9400-42, 14-9400-82, MA5-28522, MA1-20167, 17-9400-41, MA1-18420, 63-9400-42
Abnova: MAB5596, MAB5598
LifeSpan Biosciences: LS-C348102, LS-C94279, LS-C348263, LS-C348105, LS-C348103, LS-C348104
Santa Cruz Biotechnology: sc-13577 AC, sc-13577

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, radioimmunoassay, immunohistochemistry - paraffin section

citations: 5

Reference
Bushby K, Collins J, Hicks D. Collagen type VI myopathies. Adv Exp Med Biol. 2014;802:185-99 pubmed publisher
Walsh E, Kim R, Del Valle L, Weaver M, Sheffield J, Lazarovici P, et al. Importance of interaction between nerve growth factor and ?9?1 integrin in glial tumor angiogenesis. Neuro Oncol. 2012;14:890-901 pubmed publisher
Rogers M, Bailey S, Matusica D, Nicholson I, Muyderman H, Pagadala P, et al. ProNGF mediates death of Natural Killer cells through activation of the p75NTR-sortilin complex. J Neuroimmunol. 2010;226:93-103 pubmed publisher
Ebenezer G, Laast V, Dearman B, Hauer P, Tarwater P, Adams R, et al. Altered cutaneous nerve regeneration in a simian immunodeficiency virus / macaque intracutaneous axotomy model. J Comp Neurol. 2009;514:272-83 pubmed publisher
Choi D, Li D, Law S, Powell M, Raisman G. A prospective observational study of the yield of olfactory ensheathing cells cultured from biopsies of septal nasal mucosa. Neurosurgery. 2008;62:1140-4; discussion 1144-5 pubmed publisher

product information

Catalog Number :

MAB5386

Subcategory :

Neuroscience

Product Name :

Anti-Nerve Growth Factor Receptor (p75) Antibody, clone ME20.4

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P08138

Host Name :

Mouse

Antigen :

Nerve Growth Factor Receptor (p75)

Clone :

ME20.4

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-Nerve Growth Factor Receptor (p75) Antibody, clone ME20.4

Cross Reactivity :

Canine;Human;Pig;Rabbit;Sheep;Feline;Primate;Raccoon

Background :

The low affinity NGFR (Nerve growth factor receptor) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NGFR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death. It is expressed on many neuronal cells types including many embryonic forms and the receptor can be used to isolate neuronal progenitor cells

ALT Names :

NGFR; p75

Immunogen :

Human melanoma cell line (Ross, 1984).

Specificity :

Reacts with the low affinity nerve growth factor receptor (NGFR p75). The epitope recognized by the antibody maps within the third or fourth cysteine-rich repeats of the NGFR molecule. Reactivity has not been observed with rat, chicken, or mouse NGFR.

Package Size :

100 μg

Uses :

Flow Cytometry;Immunocytochemistry;Immunohistochemistry;Immunohistochemistry (Paraffin);Immunoprecipitation;Radioimmunoassay;Western Blotting

Storage :

Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.