This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
Polysialic Acid-NCAM Antibody, clone 2-2B
catalog :
MAB5324
quantity :
50 µL
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2-2B
reactivity :
African green monkey, turquoise killifish, human, mouse, rat, pigs , zebrafish
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, radioimmunoassay, immunohistochemistry - frozen section, immunohistochemistry - free floating section
citations: 108
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 1s1
Gunesch J, Dixon A, Ebrahim T, Berrien Elliott M, Tatineni S, Kumar T, et al. CD56 regulates human NK cell cytotoxicity through Pyk2. elife. 2020;9: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 2d
Zhang H, Sathyamurthy A, Liu F, Li L, Zhang L, Dong Z, et al. Agrin-Lrp4-Ror2 signaling regulates adult hippocampal neurogenesis in mice. elife. 2019;8: pubmed publisher
  • immunohistochemistry; rat; 1:400; loading ...; fig 12e
Paolone G, Falcicchia C, Lovisari F, Kokaia M, Bell W, Fradet T, et al. Long-Term, Targeted Delivery of GDNF from Encapsulated Cells Is Neuroprotective and Reduces Seizures in the Pilocarpine Model of Epilepsy. J Neurosci. 2019;39:2144-2156 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig s3c
Kawaguchi K, Kageyama R, Sano M. Topological defects control collective dynamics in neural progenitor cell cultures. Nature. 2017;545:327-331 pubmed publisher
  • immunohistochemistry - frozen section; turquoise killifish; 1:400; loading ...; fig s9a
Ripa R, Dolfi L, Terrigno M, Pandolfini L, Savino A, Arcucci V, et al. MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging. BMC Biol. 2017;15:9 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 5b
  • western blot; mouse; 1:2000; loading ...; fig 1a
Luke M, LeVatte T, Rutishauser U, Tremblay F, Clarke D. Polysialylated Neural Cell Adhesion Molecule Protects Against Light-Induced Retinal Degeneration. Invest Ophthalmol Vis Sci. 2016;57:5066-5075 pubmed publisher
  • flow cytometry; human
Parr C, Katayama S, Miki K, Kuang Y, Yoshida Y, Morizane A, et al. MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells. Sci Rep. 2016;6:32532 pubmed publisher
  • immunocytochemistry; human; 1:500; loading ...; fig 1c
  • western blot; human; 1:1000; loading ...; fig 1a
Jaako K, Waniek A, Parik K, Klimaviciusa L, Aonurm Helm A, Noortoots A, et al. Prolyl endopeptidase is involved in the degradation of neural cell adhesion molecules in vitro. J Cell Sci. 2016;129:3792-3802 pubmed
  • flow cytometry; human; loading ...; fig 2f
Guzman E, Taylor G, Hope J, Herbert R, Cubillos Zapata C, Charleston B. Transduction of skin-migrating dendritic cells by human adenovirus 5 occurs via an actin-dependent phagocytic pathway. J Gen Virol. 2016;97:2703-2718 pubmed publisher
  • immunohistochemistry; mouse; 1:500; fig 4
Auderset L, Cullen C, Young K. Low Density Lipoprotein-Receptor Related Protein 1 Is Differentially Expressed by Neuronal and Glial Populations in the Developing and Mature Mouse Central Nervous System. PLoS ONE. 2016;11:e0155878 pubmed publisher
  • western blot; pigs ; 1:1000; fig 5
Zhu X, Chen Y, Zhang N, Zheng Z, Zhao F, Liu N, et al. Molecular characterization and expression analyses of ST8Sia II and IV in piglets during postnatal development: lack of correlation between transcription and posttranslational levels. Glycoconj J. 2015;32:715-28 pubmed publisher
  • immunocytochemistry; mouse; fig 4C
  • immunohistochemistry; mouse; fig 5E
  • western blot; mouse; 1:1000; fig 4A
Watzlawik J, Kahoud R, Ng S, Painter M, Papke L, Zoecklein L, et al. Polysialic acid as an antigen for monoclonal antibody HIgM12 to treat multiple sclerosis and other neurodegenerative disorders. J Neurochem. 2015;134:865-78 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:500
  • immunohistochemistry - frozen section; human; 1:500
Xu X, Yang X, Xiong Y, Gu J, He C, Hu Y, et al. Increased expression of receptor for activated C kinase 1 in temporal lobe epilepsy. J Neurochem. 2015;133:134-43 pubmed publisher
  • immunohistochemistry; human; 1:500
Bray A, Cevallos R, Gazarian K, Lamas M. Human dental pulp stem cells respond to cues from the rat retina and differentiate to express the retinal neuronal marker rhodopsin. Neuroscience. 2014;280:142-55 pubmed publisher
  • immunohistochemistry - frozen section; pigs ; fig 4
  • western blot; pigs ; fig 4
Chen Y, Zheng Z, Zhu X, Shi Y, Tian D, Zhao F, et al. Lactoferrin Promotes Early Neurodevelopment and Cognition in Postnatal Piglets by Upregulating the BDNF Signaling Pathway and Polysialylation. Mol Neurobiol. 2015;52:256-69 pubmed publisher
  • immunocytochemistry; mouse; 1:500
Foret M, Sandstrom R, Rhodes C, Wang Y, Berger M, Lin C. Molecular targets of chromatin repressive mark H3K9me3 in primate progenitor cells within adult neurogenic niches. Front Genet. 2014;5:252 pubmed publisher
  • immunohistochemistry; mouse; 1:50
Obeidat M, Li L, Ballermann B. TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cells. Am J Physiol Renal Physiol. 2014;307:F623-33 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:300
Farioli Vecchioli S, Ceccarelli M, Saraulli D, Micheli L, Cannas S, D Alessandro F, et al. Tis21 is required for adult neurogenesis in the subventricular zone and for olfactory behavior regulating cyclins, BMP4, Hes1/5 and Ids. Front Cell Neurosci. 2014;8:98 pubmed publisher
  • immunohistochemistry; mouse; 1:200
Carnicero E, Alonso M, Carretero R, Lamus F, Moro J, de la Mano A, et al. Embryonic cerebrospinal fluid activates neurogenesis of neural precursors within the subventricular zone of the adult mouse brain. Cells Tissues Organs. 2013;198:398-404 pubmed publisher
  • western blot; mouse; 1:2000
Steel R, Miller J, Sim D, Day D. Delta-9-tetrahydrocannabinol disrupts hippocampal neuroplasticity and neurogenesis in trained, but not untrained adolescent Sprague-Dawley rats. Brain Res. 2014;1548:12-9 pubmed publisher
  • flow cytometry; human; 1:250; tbl 1
Mallon B, Hamilton R, Kozhich O, Johnson K, Fann Y, Rao M, et al. Comparison of the molecular profiles of human embryonic and induced pluripotent stem cells of isogenic origin. Stem Cell Res. 2014;12:376-86 pubmed publisher
  • immunohistochemistry - free floating section; mouse
Petrova R, Garcia A, Joyner A. Titration of GLI3 repressor activity by sonic hedgehog signaling is critical for maintaining multiple adult neural stem cell and astrocyte functions. J Neurosci. 2013;33:17490-505 pubmed publisher
  • western blot; mouse
Brennaman L, Moss M, Maness P. EphrinA/EphA-induced ectodomain shedding of neural cell adhesion molecule regulates growth cone repulsion through ADAM10 metalloprotease. J Neurochem. 2014;128:267-79 pubmed publisher
  • flow cytometry; mouse
  • immunocytochemistry; mouse; 1:300; fig 3
Azari H. Isolation and enrichment of defined neural cell populations from heterogeneous neural stem cell progeny. Methods Mol Biol. 2013;1059:95-106 pubmed publisher
  • immunohistochemistry - free floating section; human; 1:600
Dieriks B, Waldvogel H, Monzo H, Faull R, Curtis M. GABA(A) receptor characterization and subunit localization in the human sub-ventricular zone. J Chem Neuroanat. 2013;52:58-68 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; fig 9
Amschl D, Neddens J, Havas D, Flunkert S, Rabl R, Römer H, et al. Time course and progression of wild type ?-synuclein accumulation in a transgenic mouse model. BMC Neurosci. 2013;14:6 pubmed publisher
  • immunohistochemistry; mouse; 1:200
Hellwig S, Hack I, Zucker B, Brunne B, Junghans D. Reelin together with ApoER2 regulates interneuron migration in the olfactory bulb. PLoS ONE. 2012;7:e50646 pubmed publisher
  • immunohistochemistry - frozen section; zebrafish ; 1:800
Lindsey B, Darabie A, Tropepe V. The cellular composition of neurogenic periventricular zones in the adult zebrafish forebrain. J Comp Neurol. 2012;520:2275-316 pubmed publisher
  • immunohistochemistry - frozen section; African green monkey; 1:1000
Gil Perotin S, Duran Moreno M, Belzunegui S, Luquin M, Garcia Verdugo J. Ultrastructure of the subventricular zone in Macaca fascicularis and evidence of a mouse-like migratory stream. J Comp Neurol. 2009;514:533-54 pubmed publisher
  • western blot; rat
Galeano B, Klootwijk R, Manoli I, Sun M, Ciccone C, Darvish D, et al. Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamine. J Clin Invest. 2007;117:1585-94 pubmed
  • immunohistochemistry; mouse; 1:200
Tran P, Banisadr G, Ren D, Chenn A, Miller R. Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain. J Comp Neurol. 2007;500:1007-33 pubmed
  • immunohistochemistry - free floating section; mouse; 1:400
Suzuki S, Gerhold L, Böttner M, Rau S, Dela Cruz C, Yang E, et al. Estradiol enhances neurogenesis following ischemic stroke through estrogen receptors alpha and beta. J Comp Neurol. 2007;500:1064-75 pubmed
Terada Y, Jo N, Arakawa Y, Sakakura M, Yamada Y, Ukai T, et al. Human Pluripotent Stem Cell-Derived Tumor Model Uncovers the Embryonic Stem Cell Signature as a Key Driver in Atypical Teratoid/Rhabdoid Tumor. Cell Rep. 2019;26:2608-2621.e6 pubmed publisher
Liston S, McMahon S, Le Bas A, Suits M, Naismith J, Whitfield C. Periplasmic depolymerase provides insight into ABC transporter-dependent secretion of bacterial capsular polysaccharides. Proc Natl Acad Sci U S A. 2018;115:E4870-E4879 pubmed publisher
Rhodes C, Zunino G, Huang S, Cardona S, Cardona A, Berger M, et al. Region specific knock-out reveals distinct roles of chromatin modifiers in adult neurogenic niches. Cell Cycle. 2018;17:377-389 pubmed publisher
Westerlund I, Shi Y, Toskas K, Fell S, Li S, Surova O, et al. Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppression. Proc Natl Acad Sci U S A. 2017;114:E6137-E6146 pubmed publisher
Voloboueva L, Sun X, Xu L, Ouyang Y, Giffard R. Distinct Effects of miR-210 Reduction on Neurogenesis: Increased Neuronal Survival of Inflammation But Reduced Proliferation Associated with Mitochondrial Enhancement. J Neurosci. 2017;37:3072-3084 pubmed publisher
Oprych K, Cotfas D, Choi D. Common olfactory ensheathing glial markers in the developing human olfactory system. Brain Struct Funct. 2017;222:1877-1895 pubmed publisher
Ley D, Romantsik O, Vallius S, Sveinsdottir K, Sveinsdottir S, Agyemang A, et al. High Presence of Extracellular Hemoglobin in the Periventricular White Matter Following Preterm Intraventricular Hemorrhage. Front Physiol. 2016;7:330 pubmed publisher
López Hidalgo R, Ballestín R, Vega J, Blasco Ibáñez J, Crespo C, Gilabert Juan J, et al. Hypocellularity in the Murine Model for Down Syndrome Ts65Dn Is Not Affected by Adult Neurogenesis. Front Neurosci. 2016;10:75 pubmed publisher
Lundgaard I, Li B, Xie L, Kang H, Sanggaard S, Haswell J, et al. Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism. Nat Commun. 2015;6:6807 pubmed publisher
Trost A, Schroedl F, Marschallinger J, Rivera F, Bogner B, Runge C, et al. Characterization of dsRed2-positive cells in the doublecortin-dsRed2 transgenic adult rat retina. Histochem Cell Biol. 2014;142:601-17 pubmed publisher
Wang C, You Y, Qi D, Zhou X, Wang L, Wei S, et al. Human and monkey striatal interneurons are derived from the medial ganglionic eminence but not from the adult subventricular zone. J Neurosci. 2014;34:10906-23 pubmed publisher
Sandstrom R, Foret M, Grow D, Haugen E, Rhodes C, Cardona A, et al. Epigenetic regulation by chromatin activation mark H3K4me3 in primate progenitor cells within adult neurogenic niche. Sci Rep. 2014;4:5371 pubmed publisher
Boekhoorn K, van Dis V, Goedknegt E, Sobel A, Lucassen P, Hoogenraad C. The microtubule destabilizing protein stathmin controls the transition from dividing neuronal precursors to postmitotic neurons during adult hippocampal neurogenesis. Dev Neurobiol. 2014;74:1226-42 pubmed publisher
Orts Del Immagine A, Kastner A, Tillement V, Tardivel C, Trouslard J, Wanaverbecq N. Morphology, distribution and phenotype of polycystin kidney disease 2-like 1-positive cerebrospinal fluid contacting neurons in the brainstem of adult mice. PLoS ONE. 2014;9:e87748 pubmed publisher
Djordjevic A, Bursać B, Velickovic N, Vasiljević A, Matić G. The impact of different fructose loads on insulin sensitivity, inflammation, and PSA-NCAM-mediated plasticity in the hippocampus of fructose-fed male rats. Nutr Neurosci. 2015;18:66-75 pubmed publisher
Takamori Y, Wakabayashi T, Mori T, Kosaka J, Yamada H. Organization and cellular arrangement of two neurogenic regions in the adult ferret (Mustela putorius furo) brain. J Comp Neurol. 2014;522:1818-38 pubmed publisher
Slomianka L, Drenth T, Cavegn N, Menges D, Lazic S, Phalanndwa M, et al. The hippocampus of the eastern rock sengi: cytoarchitecture, markers of neuronal function, principal cell numbers, and adult neurogenesis. Front Neuroanat. 2013;7:34 pubmed publisher
Lazzari M, Bettini S, Franceschini V. Immunocytochemical characterisation of olfactory ensheathing cells of zebrafish. J Anat. 2014;224:192-206 pubmed publisher
Lindhout T, Bainbridge C, Costain W, Gilbert M, Wakarchuk W. Biochemical characterization of a polysialyltransferase from Mannheimia haemolytica A2 and comparison to other bacterial polysialyltransferases. PLoS ONE. 2013;8:e69888 pubmed publisher
Luo J, Qiu Z, Chen J, Zhang L, Liu W, Tan Y, et al. Maternal and early life arsenite exposure impairs neurodevelopment and increases the expression of PSA-NCAM in hippocampus of rat offspring. Toxicology. 2013;311:99-106 pubmed publisher
Xapelli S, Agasse F, Sard Arroyo L, Bernardino L, Santos T, Ribeiro F, et al. Activation of type 1 cannabinoid receptor (CB1R) promotes neurogenesis in murine subventricular zone cell cultures. PLoS ONE. 2013;8:e63529 pubmed publisher
Fredrich M, Zeber A, Hildebrandt H, Illing R. Differential molecular profiles of astrocytes in degeneration and re-innervation after sensory deafferentation of the adult rat cochlear nucleus. Eur J Neurosci. 2013;38:2041-56 pubmed publisher
Jungenitz T, Radic T, Jedlicka P, Schwarzacher S. High-frequency stimulation induces gradual immediate early gene expression in maturing adult-generated hippocampal granule cells. Cereb Cortex. 2014;24:1845-57 pubmed publisher
Brunjes P. The mouse olfactory peduncle. 2.The anterior limb of the anterior commissure. Front Neuroanat. 2012;6:51 pubmed publisher
Zussy C, Brureau A, Keller E, Marchal S, Blayo C, Delair B, et al. Alzheimer's disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-? peptide injection in rats. PLoS ONE. 2013;8:e53117 pubmed publisher
Moon Y, Kim J, Choi S, Cho H, Kim H, Sun W. Expression of ezrin in subventricular zone neural stem cells and their progeny in adult and developing mice. Histochem Cell Biol. 2013;139:403-13 pubmed publisher
Yan X, Cai Y, Shelton J, Deng S, Luo X, Oddo S, et al. Chronic temporal lobe epilepsy is associated with enhanced Alzheimer-like neuropathology in 3×Tg-AD mice. PLoS ONE. 2012;7:e48782 pubmed publisher
Sanin V, Heeß C, Kretzschmar H, Schuller U. Recruitment of neural precursor cells from circumventricular organs of patients with cerebral ischaemia. Neuropathol Appl Neurobiol. 2013;39:510-8 pubmed publisher
Elvira G, Garcia I, Benito M, Gallo J, Desco M, Penadés S, et al. Live imaging of mouse endogenous neural progenitors migrating in response to an induced tumor. PLoS ONE. 2012;7:e44466 pubmed publisher
Zhao W, Cheng C, Theriault K, SHERIDAN S, Tsai L, Haggarty S. A high-throughput screen for Wnt/?-catenin signaling pathway modulators in human iPSC-derived neural progenitors. J Biomol Screen. 2012;17:1252-63 pubmed
Budinich C, Chen H, Lowe D, Rosenberger J, Bernstock J, McCabe J. Mouse brain PSA-NCAM levels are altered by graded-controlled cortical impact injury. Neural Plast. 2012;2012:378307 pubmed publisher
Lazzari M, Bettini S, Franceschini V. Immunocytochemical characterization of olfactory ensheathing cells in fish. Brain Struct Funct. 2013;218:539-49 pubmed publisher
Blackmore D, Reynolds B, Golmohammadi M, Large B, Aguilar R, HARO L, et al. Growth hormone responsive neural precursor cells reside within the adult mammalian brain. Sci Rep. 2012;2:250 pubmed publisher
Yan X, Cai Y, Zhang X, Luo X, Cai H, Rose G, et al. BACE1 elevation is associated with aberrant limbic axonal sprouting in epileptic CD1 mice. Exp Neurol. 2012;235:228-37 pubmed publisher
Sheridan G, Dev K. S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures. Glia. 2012;60:382-92 pubmed publisher
Baumgart E, Barbosa J, Bally Cuif L, Gotz M, Ninkovic J. Stab wound injury of the zebrafish telencephalon: a model for comparative analysis of reactive gliosis. Glia. 2012;60:343-57 pubmed publisher
Gilley J, Kernie S. Excitatory amino acid transporter 2 and excitatory amino acid transporter 1 negatively regulate calcium-dependent proliferation of hippocampal neural progenitor cells and are persistently upregulated after injury. Eur J Neurosci. 2011;34:1712-23 pubmed publisher
Bélanger M, Di Cristo G. Sensory experience differentially modulates the mRNA expression of the polysialyltransferases ST8SiaII and ST8SiaIV in postnatal mouse visual cortex. PLoS ONE. 2011;6:e24874 pubmed publisher
Siebzehnrubl F, Vedam Mai V, Azari H, Reynolds B, Deleyrolle L. Isolation and characterization of adult neural stem cells. Methods Mol Biol. 2011;750:61-77 pubmed publisher
Marlatt M, Philippens I, Manders E, Czeh B, Joels M, Krugers H, et al. Distinct structural plasticity in the hippocampus and amygdala of the middle-aged common marmoset (Callithrix jacchus). Exp Neurol. 2011;230:291-301 pubmed publisher
Linterman K, Palmer D, Kay G, Barry L, Mitchell N, McFarlane R, et al. Lentiviral-mediated gene transfer to the sheep brain: implications for gene therapy in Batten disease. Hum Gene Ther. 2011;22:1011-20 pubmed publisher
Wang C, Liu F, Liu Y, Zhao C, You Y, Wang L, et al. Identification and characterization of neuroblasts in the subventricular zone and rostral migratory stream of the adult human brain. Cell Res. 2011;21:1534-50 pubmed publisher
Kim T, Kim H, Sun W. Spontaneous reactive astrogliosis in the dentate gyrus of Bax-deficient mice. Mol Cells. 2011;31:379-83 pubmed publisher
Liu H, Guthrie K. Neuronal replacement in the injured olfactory bulb. Exp Neurol. 2011;228:270-82 pubmed publisher
Walczak P, All A, Rumpal N, Gorelik M, Kim H, Maybhate A, et al. Human glial-restricted progenitors survive, proliferate, and preserve electrophysiological function in rats with focal inflammatory spinal cord demyelination. Glia. 2011;59:499-510 pubmed publisher
Encinas J, Hamani C, Lozano A, Enikolopov G. Neurogenic hippocampal targets of deep brain stimulation. J Comp Neurol. 2011;519:6-20 pubmed publisher
Tong J, Furukawa Y, Sherwin A, Hornykiewicz O, Kish S. Heterogeneous intrastriatal pattern of proteins regulating axon growth in normal adult human brain. Neurobiol Dis. 2011;41:458-68 pubmed publisher
de la Rosa Prieto C, Saiz Sanchez D, Ubeda Banon I, Argandoña Palacios L, Garcia Muñozguren S, Martinez Marcos A. Neurogenesis in subclasses of vomeronasal sensory neurons in adult mice. Dev Neurobiol. 2010;70:961-70 pubmed publisher
Zhao S, Zhou Y, Gross J, Miao P, Qiu L, Wang D, et al. Fluorescent labeling of newborn dentate granule cells in GAD67-GFP transgenic mice: a genetic tool for the study of adult neurogenesis. PLoS ONE. 2010;5: pubmed publisher
Duveau V, Fritschy J. PSA-NCAM-dependent GDNF signaling limits neurodegeneration and epileptogenesis in temporal lobe epilepsy. Eur J Neurosci. 2010;32:89-98 pubmed publisher
Mulder J, Spence L, Tortoriello G, DiNieri J, Uhlen M, Shui B, et al. Secretagogin is a Ca2+-binding protein identifying prospective extended amygdala neurons in the developing mammalian telencephalon. Eur J Neurosci. 2010;31:2166-77 pubmed publisher
Horn Z, Ringstedt T, Blaesse P, Kaila K, Herlenius E. Premature expression of KCC2 in embryonic mice perturbs neural development by an ion transport-independent mechanism. Eur J Neurosci. 2010;31:2142-55 pubmed publisher
Campodónico P, de Kier Joffé E, Urtreger A, Lauria L, Lastiri J, Puricelli L, et al. The neural cell adhesion molecule is involved in the metastatic capacity in a murine model of lung cancer. Mol Carcinog. 2010;49:386-97 pubmed publisher
Choi J, Shin Y, Lee J, Yun H, Cha J, Choi J, et al. Expression of vascular endothelial growth factor receptor-3 mRNA in the rat developing forebrain and retina. J Comp Neurol. 2010;518:1064-81 pubmed publisher
Prolo L, Vogel H, Reimer R. The lysosomal sialic acid transporter sialin is required for normal CNS myelination. J Neurosci. 2009;29:15355-65 pubmed publisher
Zhang X, Cai Y, Chu Y, Chen E, Feng J, Luo X, et al. Doublecortin-expressing cells persist in the associative cerebral cortex and amygdala in aged nonhuman primates. Front Neuroanat. 2009;3:17 pubmed publisher
He P, Shen Y. Interruption of beta-catenin signaling reduces neurogenesis in Alzheimer's disease. J Neurosci. 2009;29:6545-57 pubmed publisher
Roybon L, Deierborg T, Brundin P, Li J. Involvement of Ngn2, Tbr and NeuroD proteins during postnatal olfactory bulb neurogenesis. Eur J Neurosci. 2009;29:232-43 pubmed publisher
Cai Y, Xiong K, Chu Y, Luo D, Luo X, Yuan X, et al. Doublecortin expression in adult cat and primate cerebral cortex relates to immature neurons that develop into GABAergic subgroups. Exp Neurol. 2009;216:342-56 pubmed publisher
Kam M, Curtis M, McGlashan S, Connor B, Nannmark U, Faull R. The cellular composition and morphological organization of the rostral migratory stream in the adult human brain. J Chem Neuroanat. 2009;37:196-205 pubmed publisher
Campanelli J, Sandrock R, Wheatley W, Xue H, Zheng J, Liang F, et al. Expression profiling of human glial precursors. BMC Dev Biol. 2008;8:102 pubmed publisher
Wu J, Dechon J, Xue F, Li G, Ellsworth K, Gao M, et al. GABA(A) receptor-mediated excitation in dissociated neurons from human hypothalamic hamartomas. Exp Neurol. 2008;213:397-404 pubmed publisher
Castiglione M, Calafiore M, Costa L, Sortino M, Nicoletti F, Copani A. Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice. Neuropharmacology. 2008;55:560-7 pubmed publisher
Xiong K, Luo D, Patrylo P, Luo X, Struble R, Clough R, et al. Doublecortin-expressing cells are present in layer II across the adult guinea pig cerebral cortex: partial colocalization with mature interneuron markers. Exp Neurol. 2008;211:271-82 pubmed publisher
Kao H, Li P, Chao H, Janoschka S, Pham K, Feng J, et al. Early involvement of synapsin III in neural progenitor cell development in the adult hippocampus. J Comp Neurol. 2008;507:1860-70 pubmed publisher
Del Carmen Gómez Roldán M, Perez Martin M, Capilla Gonzalez V, Cifuentes M, Perez J, Garcia Verdugo J, et al. Neuroblast proliferation on the surface of the adult rat striatal wall after focal ependymal loss by intracerebroventricular injection of neuraminidase. J Comp Neurol. 2008;507:1571-87 pubmed publisher
Di Cristo G, Chattopadhyaya B, Kuhlman S, Fu Y, Bélanger M, Wu C, et al. Activity-dependent PSA expression regulates inhibitory maturation and onset of critical period plasticity. Nat Neurosci. 2007;10:1569-77 pubmed
Nam S, Kim Y, Dryanovski D, Walker A, Goings G, Woolfrey K, et al. Dynamic features of postnatal subventricular zone cell motility: a two-photon time-lapse study. J Comp Neurol. 2007;505:190-208 pubmed
Kimura K, Ieda M, Kanazawa H, Yagi T, Tsunoda M, Ninomiya S, et al. Cardiac sympathetic rejuvenation: a link between nerve function and cardiac hypertrophy. Circ Res. 2007;100:1755-64 pubmed
Bullmann T, de Silva R, Holzer M, Mori H, Arendt T. Expression of embryonic tau protein isoforms persist during adult neurogenesis in the hippocampus. Hippocampus. 2007;17:98-102 pubmed
Macas J, Nern C, Plate K, Momma S. Increased generation of neuronal progenitors after ischemic injury in the aged adult human forebrain. J Neurosci. 2006;26:13114-9 pubmed
Ledergerber D, Fritschy J, Kralic J. Impairment of dentate gyrus neuronal progenitor cell differentiation in a mouse model of temporal lobe epilepsy. Exp Neurol. 2006;199:130-42 pubmed
Faiz M, Acarin L, Peluffo H, Villapol S, Castellano B, Gonzalez B. Antioxidant Cu/Zn SOD: expression in postnatal brain progenitor cells. Neurosci Lett. 2006;401:71-6 pubmed
Charrier C, Coronas V, Fombonne J, Roger M, Jean A, Krantic S, et al. Characterization of neural stem cells in the dorsal vagal complex of adult rat by in vivo proliferation labeling and in vitro neurosphere assay. Neuroscience. 2006;138:5-16 pubmed
Schwartz P, Nethercott H, Kirov I, Ziaeian B, Young M, Klassen H. Expression of neurodevelopmental markers by cultured porcine neural precursor cells. Stem Cells. 2005;23:1286-94 pubmed
Calafiore M, Battaglia G, Zappala A, Trovato Salinaro E, Caraci F, Caruso M, et al. Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to beta-amyloid. Neurobiol Aging. 2006;27:606-13 pubmed
product information
Catalog Number :
MAB5324
Subcategory :
Neuroscience
Product Name :
Anti-Polysialic Acid-NCAM Antibody, clone 2-2B
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Gene ID :
P13591
Host Name :
Mouse
Antigen :
Polysialic Acid-NCAM
Clone :
2-2B
Conjugate :
Ascites
Isotype :
IgM
Product Description :
Anti-Polysialic Acid-NCAM Antibody, clone 2-2B
Cross Reactivity :
Human;Rat;Mouse;Vertebrates
Background :
Polysialic acid (PSA) is a long, linear homopolymer that is attached to the neural cell adhesion molecule (NCAM). It has the remarkable ability to down-regulate a wide variety of contact-dependent cell interactions. This activity is believed to stem from the ability of the charged polymer to occupy a large hydrated volume and thereby cause a direct physical hindrance of cell–cell contact. The regulated expression of PSA has been shown to promote a reduction in cell interactions that can create permissive conditions for changes in the structure of a variety of tissues. The broadest expression of PSA occurs on precursor cells during early development and plays a role in promotion of the migration of these cells after cell division. In most cases, PSA expression is lost after the migration process is completed. However, the axons of neurons often retain PSA to bundle,sprout, and branch appropriately during axon path-finding.
ALT Names :
PSA-NCAM
Immunogen :
Viable Meningococcus group B (strain 355).
Specificity :
Reacts with alpha 2-8 linked neuraminic acid (NeuAc-alpha 2-8) n with n 10. This polymer is usually termed polysialic acid (PSA). In vertebrates PSA is linked to neural cell adhesion molecule (NCAM, CD56), in bacteria it is associated with capsula of meningococcus strain group B.
Package Size :
50 µL
Uses :
Immunocytochemistry;Immunohistochemistry;Radioimmunoassay;Western Blotting
Storage :
Stable for 1 year at -20ºC in undiluted aliquots from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgM and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

Hundreds of New Antibodies in the areas of:
  • • Cancer
  • • Nuclear Signaling
  • • Apoptosis
  • • Cardiovascular Disease
  • • Developmental Biology
  • • Metabolic Disease
  • • Neurodegenerative Disease
  • • Cell Biology
View all the new antibodies at www.emdmillipore.com.