Chondroitin Sulfate Proteoglycan Antibody, Brain (core protein), clone Cat-301 | EMD Millipore MAB5284 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Chondroitin Sulfate Proteoglycan Antibody, Brain (core protein), clone Cat-301

catalog :

MAB5284

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Cat-301

reactivity :

African green monkey, human, Xenopus laevis, domestic rabbit, rhesus macaque

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 25

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; rhesus macaque; 1:50	Mueller A, Davis A, Sovich S, Carlson S, Robinson F. Distribution of N-Acetylgalactosamine-Positive Perineuronal Nets in the Macaque Brain: Anatomy and Implications. Neural Plast. 2016;2016:6021428 pubmed publisher
immunohistochemistry - frozen section; human; fig s1	Pantazopoulos H, Markota M, Jaquet F, Ghosh D, Wallin A, Santos A, et al. Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala. Transl Psychiatry. 2015;5:e496 pubmed publisher
immunohistochemistry; Xenopus laevis; 1:100 western blot; Xenopus laevis; 1:250	Gaal B, Racz E, Juhasz T, Holló K, Matesz C. Distribution of extracellular matrix macromolecules in the vestibular nuclei and cerebellum of the frog, Rana esculenta. Neuroscience. 2014;258:162-73 pubmed publisher
immunohistochemistry - frozen section; domestic rabbit western blot; domestic rabbit immunohistochemistry - frozen section; human	Vinukonda G, Zia M, Bhimavarapu B, Hu F, Feinberg M, Bokhari A, et al. Intraventricular hemorrhage induces deposition of proteoglycans in premature rabbits, but their in vivo degradation with chondroitinase does not restore myelination, ventricle size and neurological recovery. Exp Neurol. 2013;247:630-44 pubmed publisher
immunohistochemistry - paraffin section; human; 1:500 immunohistochemistry - frozen section; African green monkey; 1:100	Horn A, Eberhorn A, Hartig W, Ardeleanu P, Messoudi A, Büttner Ennever J. Perioculomotor cell groups in monkey and man defined by their histochemical and functional properties: reappraisal of the Edinger-Westphal nucleus. J Comp Neurol. 2008;507:1317-35 pubmed publisher
	Hunyadi A, Gaál B, Matesz C, Mészár Z, Morawski M, Reimann K, et al. Distribution and classification of the extracellular matrix in the olfactory bulb. Brain Struct Funct. 2020;225:321-344 pubmed publisher
	Luo F, Tran A, Xin L, Sanapala C, Lang B, Silver J, et al. Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis. Nat Commun. 2018;9:4126 pubmed publisher
	Hirono M, Watanabe S, Karube F, Fujiyama F, Kawahara S, Nagao S, et al. Perineuronal Nets in the Deep Cerebellar Nuclei Regulate GABAergic Transmission and Delay Eyeblink Conditioning. J Neurosci. 2018;38:6130-6144 pubmed publisher
	Eggers S, Horn A, Roeber S, HÃ¤rtig W, Nair G, Reich D, et al. Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets. PLoS ONE. 2015;10:e0132075 pubmed publisher
	Radtke Schuller S, Seeler S, Grothe B. Restricted loss of olivocochlear but not vestibular efferent neurons in the senescent gerbil (Meriones unguiculatus). Front Aging Neurosci. 2015;7:4 pubmed publisher
	Vorobyov V, Kwok J, Fawcett J, Sengpiel F. Effects of digesting chondroitin sulfate proteoglycans on plasticity in cat primary visual cortex. J Neurosci. 2013;33:234-43 pubmed publisher
	Felch D, Van Hooser S. Molecular compartmentalization of lateral geniculate nucleus in the gray squirrel (Sciurus carolinensis). Front Neuroanat. 2012;6:12 pubmed publisher
	Lendvai D, Morawski M, Bruckner G, Negyessy L, Baksa G, Glasz T, et al. Perisynaptic aggrecan-based extracellular matrix coats in the human lateral geniculate body devoid of perineuronal nets. J Neurosci Res. 2012;90:376-87 pubmed publisher
	Andrews E, Richards R, Yin F, Viapiano M, Jakeman L. Alterations in chondroitin sulfate proteoglycan expression occur both at and far from the site of spinal contusion injury. Exp Neurol. 2012;235:174-87 pubmed publisher
	Homman Ludiye J, Manger P, Bourne J. Immunohistochemical parcellation of the ferret (Mustela putorius) visual cortex reveals substantial homology with the cat (Felis catus). J Comp Neurol. 2010;518:4439-62 pubmed publisher
	Chi G, Kim M, Kim D, Jiang M, Son Y. Schwann cells differentiated from spheroid-forming cells of rat subcutaneous fat tissue myelinate axons in the spinal cord injury. Exp Neurol. 2010;222:304-17 pubmed publisher
	Hawthorne A, Wylie C, Landmesser L, Deneris E, Silver J. Serotonergic neurons migrate radially through the neuroepithelium by dynamin-mediated somal translocation. J Neurosci. 2010;30:420-30 pubmed publisher
	Maricich S, Xia A, Mathes E, Wang V, Oghalai J, Fritzsch B, et al. Atoh1-lineal neurons are required for hearing and for the survival of neurons in the spiral ganglion and brainstem accessory auditory nuclei. J Neurosci. 2009;29:11123-33 pubmed publisher
	Helfer J, Calizo L, Dong W, Goodlett C, Greenough W, Klintsova A. Binge-like postnatal alcohol exposure triggers cortical gliogenesis in adolescent rats. J Comp Neurol. 2009;514:259-71 pubmed publisher
	Carulli D, Rhodes K, Fawcett J. Upregulation of aggrecan, link protein 1, and hyaluronan synthases during formation of perineuronal nets in the rat cerebellum. J Comp Neurol. 2007;501:83-94 pubmed
	Vitellaro Zuccarello L, Bosisio P, Mazzetti S, Monti C, De Biasi S. Differential expression of several molecules of the extracellular matrix in functionally and developmentally distinct regions of rat spinal cord. Cell Tissue Res. 2007;327:433-47 pubmed
	Dizon M, Shin L, Sundholm Peters N, Kang E, Szele F. Subventricular zone cells remain stable in vitro after brain injury. Neuroscience. 2006;142:717-25 pubmed
	Carulli D, Rhodes K, Brown D, Bonnert T, Pollack S, Oliver K, et al. Composition of perineuronal nets in the adult rat cerebellum and the cellular origin of their components. J Comp Neurol. 2006;494:559-77 pubmed
	Eberhorn A, Buttner Ennever J, Horn A. Identification of motoneurons supplying multiply- or singly-innervated extraocular muscle fibers in the rat. Neuroscience. 2006;137:891-903 pubmed
	Eberhorn A, Ardeleanu P, Büttner Ennever J, Horn A. Histochemical differences between motoneurons supplying multiply and singly innervated extraocular muscle fibers. J Comp Neurol. 2005;491:352-66 pubmed

product information

Catalog Number :

MAB5284

Subcategory :

Neuroscience

Product Name :

Anti-Chondroitin Sulfate Proteoglycan Antibody, Brain (core protein), clone Cat-301

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P16112

Host Name :

Mouse

Antigen :

Chondroitin Sulfate Proteoglycan

Clone :

Cat-301

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-Chondroitin Sulfate Proteoglycan Antibody, Brain (core protein), clone Cat-301

Cross Reactivity :

Guinea Pig;Human;Hamster;Rat;Feline;Gerbil;Primate

Background :

The antigen recognized by this clone, CAT-301 is a proteoglycan that is developmentaly regulated, high molecular chondroitin sulphate proteoglycan found on the extracellular surface of mammalian neurons. It is expressed late in development and although no definitive role has been identified for CAT-301, it is believed to have a role in the stabilisation of synaptic structure. The name derives from the name of the monoclonal antibody originally used to identified by its expression, which was detected immunocytochemicaly Disruption of the normal patterns of neuronal activity during the critical early postnatal period by physical or biochemical means results in a large and irreversible reduction in levels of CAT-301. Similar intervention in mature animals has no effect CAT-301 is related to aggrecan from articular cartilage. The CAT-301 antibody immunoreacts with aggrecan, and the chondroitinase treated aggrecan and CAT-301 both have apparent sizes of 550kDa. However CAT- 301 is not glycosylated by keratan sulphate, as aggrecan is.

ALT Names :

CSPG

Immunogen :

Feline spinal cord fixed gray matter.

Specificity :

Chondroitin sulfate proteoglycan (CSPG), brain core protein.

Package Size :

100 µg

Uses :

Immunoprecipitation;Western Blotting;Immunocytochemistry;Immunohistochemistry

Storage :

Maintain at 2-8°C in undiluted aliquots for up to 6 months.