This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
Neural Cell Adhesion Molecule L1 Antibody, clone 324
catalog :
MAB5272
quantity :
100 μg
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
324

The same clone is also sold as:
reactivity :
mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
citations: 43
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:200; loading ...; fig 3q
Roy A, Murphy R, Deng M, MacDonald J, Bammler T, Aldinger K, et al. PI3K-Yap activity drives cortical gyrification and hydrocephalus in mice. elife. 2019;8: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:150; loading ...; fig 5a
  • immunocytochemistry; mouse; 1:150; loading ...; fig s4a
Tai Y, Gallo N, Wang M, Yu J, Van Aelst L. Axo-axonic Innervation of Neocortical Pyramidal Neurons by GABAergic Chandelier Cells Requires AnkyrinG-Associated L1CAM. Neuron. 2019;102:358-372.e9 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:500; loading ...; fig 2a
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 1a
Lindenmaier L, Parmentier N, Guo C, Tissir F, Wright K. Dystroglycan is a scaffold for extracellular axon guidance decisions. elife. 2019;8: pubmed publisher
  • immunohistochemistry - free floating section; mouse; fig s4a
Thion M, Low D, Silvin A, Chen J, Grisel P, Schulte Schrepping J, et al. Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner. Cell. 2018;172:500-516.e16 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 5-s1
Dragich J, Kuwajima T, Hirose Ikeda M, Yoon M, Eenjes E, Bosco J, et al. Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain. elife. 2016;5: pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 6
Saito Y, Miranda Rottmann S, Ruggiu M, Park C, Fak J, Zhong R, et al. NOVA2-mediated RNA regulation is required for axonal pathfinding during development. elife. 2016;5: pubmed publisher
  • immunohistochemistry; mouse; 1:50; fig 6
Hakanen J, Salminen M. Defects in neural guidepost structures and failure to remove leptomeningeal cells from the septal midline behind the interhemispheric fusion defects in Netrin1 deficient mice. Int J Dev Neurosci. 2015;47:206-15 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; fig 1
Laclef C, Anselme I, Besse L, Catala M, Palmyre A, Baas D, et al. The role of primary cilia in corpus callosum formation is mediated by production of the Gli3 repressor. Hum Mol Genet. 2015;24:4997-5014 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:400
Ngo L, Haas M, Qu Z, Li S, Zenker J, Teng K, et al. TUBB5 and its disease-associated mutations influence the terminal differentiation and dendritic spine densities of cerebral cortical neurons. Hum Mol Genet. 2014;23:5147-58 pubmed publisher
  • immunohistochemistry - frozen section; mouse
Li Q, Zhang Z, Li Z, Zhou M, Liu B, Pan L, et al. ADAM17 is critical for multipolar exit and radial migration of neuronal intermediate progenitor cells in mice cerebral cortex. PLoS ONE. 2013;8:e65703 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500
Eckler M, McKenna W, Taghvaei S, McConnell S, Chen B. Fezf1 and Fezf2 are required for olfactory development and sensory neuron identity. J Comp Neurol. 2011;519:1829-46 pubmed publisher
Brosig A, Fuchs J, Ipek F, Kroon C, Schrötter S, Vadhvani M, et al. The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches. Cell Rep. 2019;29:2028-2040.e8 pubmed publisher
Saito K, Okamoto M, Watanabe Y, Noguchi N, Nagasaka A, Nishina Y, et al. Dorsal-to-Ventral Cortical Expansion Is Physically Primed by Ventral Streaming of Early Embryonic Preplate Neurons. Cell Rep. 2019;29:1555-1567.e5 pubmed publisher
Arai Y, Cwetsch A, Coppola E, Cipriani S, Nishihara H, Kanki H, et al. Evolutionary Gain of Dbx1 Expression Drives Subplate Identity in the Cerebral Cortex. Cell Rep. 2019;29:645-658.e5 pubmed publisher
Gorla M, Santiago C, Chaudhari K, Layman A, Oliver P, Bashaw G. Ndfip Proteins Target Robo Receptors for Degradation and Allow Commissural Axons to Cross the Midline in the Developing Spinal Cord. Cell Rep. 2019;26:3298-3312.e4 pubmed publisher
Zhang M, Ergin V, Lin L, Stork C, Chen L, Zheng S. Axonogenesis Is Coordinated by Neuron-Specific Alternative Splicing Programming and Splicing Regulator PTBP2. Neuron. 2019;101:690-706.e10 pubmed publisher
Risher W, Kim N, Koh S, Choi J, Mitev P, Spence E, et al. Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1. J Cell Biol. 2018;217:3747-3765 pubmed publisher
Kannan M, Bayam E, Wagner C, Rinaldi B, Kretz P, Tilly P, et al. WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. Proc Natl Acad Sci U S A. 2017;114:E9308-E9317 pubmed publisher
Matsumoto H, Nagashima M. Shift in the function of netrin-1 from axon outgrowth to axon branching in developing cerebral cortical neurons. BMC Neurosci. 2017;18:74 pubmed publisher
Gomez Sanchez J, Pilch K, van der Lans M, Fazal S, Benito C, Wagstaff L, et al. After Nerve Injury, Lineage Tracing Shows That Myelin and Remak Schwann Cells Elongate Extensively and Branch to Form Repair Schwann Cells, Which Shorten Radically on Remyelination. J Neurosci. 2017;37:9086-9099 pubmed publisher
Burk K, Mire E, Bellon A, Hocine M, Guillot J, Moraes F, et al. Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits. Nat Commun. 2017;8:14508 pubmed publisher
Risher W, Patel S, Kim I, Uezu A, Bhagat S, Wilton D, et al. Astrocytes refine cortical connectivity at dendritic spines. elife. 2014;3: pubmed publisher
Zhang Y, Chen K, Sloan S, Bennett M, Scholze A, O Keeffe S, et al. An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J Neurosci. 2014;34:11929-47 pubmed publisher
Srivatsa S, Parthasarathy S, Britanova O, Bormuth I, Donahoo A, Ackerman S, et al. Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation. Nat Commun. 2014;5:3708 pubmed publisher
Dai J, Buhusi M, Demyanenko G, Brennaman L, Hruska M, Dalva M, et al. Neuron glia-related cell adhesion molecule (NrCAM) promotes topographic retinocollicular mapping. PLoS ONE. 2013;8:e73000 pubmed publisher
Collazos Castro J, Hernández Labrado G, Polo J, García Rama C. N-Cadherin- and L1-functionalised conducting polymers for synergistic stimulation and guidance of neural cell growth. Biomaterials. 2013;34:3603-17 pubmed publisher
Ferguson T, Scherer S. Neuronal cadherin (NCAD) increases sensory neurite formation and outgrowth on astrocytes. Neurosci Lett. 2012;522:108-12 pubmed publisher
Dai J, Dalal J, Thakar S, Henkemeyer M, Lemmon V, Harunaga J, et al. EphB regulates L1 phosphorylation during retinocollicular mapping. Mol Cell Neurosci. 2012;50:201-10 pubmed publisher
Chen Y, Magnani D, Theil T, Pratt T, Price D. Evidence that descending cortical axons are essential for thalamocortical axons to cross the pallial-subpallial boundary in the embryonic forebrain. PLoS ONE. 2012;7:e33105 pubmed publisher
Bacon C, Endris V, Andermatt I, Niederkofler V, Waltereit R, Bartsch D, et al. Evidence for a role of srGAP3 in the positioning of commissural axons within the ventrolateral funiculus of the mouse spinal cord. PLoS ONE. 2011;6:e19887 pubmed publisher
Conway C, Howe K, Nettleton N, Price D, Mason J, Pratt T. Heparan sulfate sugar modifications mediate the functions of slits and other factors needed for mouse forebrain commissure development. J Neurosci. 2011;31:1955-70 pubmed publisher
Hertel N, Redies C. Absence of layer-specific cadherin expression profiles in the neocortex of the reeler mutant mouse. Cereb Cortex. 2011;21:1105-17 pubmed publisher
de Anda F, Meletis K, Ge X, Rei D, Tsai L. Centrosome motility is essential for initial axon formation in the neocortex. J Neurosci. 2010;30:10391-406 pubmed publisher
Sakurai K, Toyoshima M, Ueda H, Matsubara K, Takeda Y, Karagogeos D, et al. Contribution of the neural cell recognition molecule NB-3 to synapse formation between parallel fibers and Purkinje cells in mouse. Dev Neurobiol. 2009;69:811-24 pubmed publisher
Nobbio L, Sturla L, Fiorese F, Usai C, Basile G, Moreschi I, et al. P2X7-mediated increased intracellular calcium causes functional derangement in Schwann cells from rats with CMT1A neuropathy. J Biol Chem. 2009;284:23146-58 pubmed publisher
Hatanaka Y, Matsumoto T, Yanagawa Y, Fujisawa H, Murakami F, Masu M. Distinct roles of neuropilin 1 signaling for radial and tangential extension of callosal axons. J Comp Neurol. 2009;514:215-25 pubmed publisher
Manuel M, Pratt T, Liu M, Jeffery G, Price D. Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance. BMC Dev Biol. 2008;8:59 pubmed publisher
Wang X, Nadarajah B, Robinson A, McColl B, Jin J, Dajas Bailador F, et al. Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death. Mol Cell Biol. 2007;27:7935-46 pubmed
Saito T, Yamada K, Wang Y, Tanaka Y, Ohtomo K, Ishikawa K, et al. Expression of ABCA2 protein in both non-myelin-forming and myelin-forming Schwann cells in the rodent peripheral nerve. Neurosci Lett. 2007;414:35-40 pubmed
Nagata I, Ono K, Kawana A, Kimura Kuroda J. Aligned neurite bundles of granule cells regulate orientation of Purkinje cell dendrites by perpendicular contact guidance in two-dimensional and three-dimensional mouse cerebellar cultures. J Comp Neurol. 2006;499:274-89 pubmed
Jevince A, Kadison S, Pittman A, Chien C, Kaprielian Z. Distribution of EphB receptors and ephrin-B1 in the developing vertebrate spinal cord. J Comp Neurol. 2006;497:734-50 pubmed
Andrews W, Liapi A, Plachez C, Camurri L, Zhang J, Mori S, et al. Robo1 regulates the development of major axon tracts and interneuron migration in the forebrain. Development. 2006;133:2243-52 pubmed
Steele Perkins G, Plachez C, Butz K, Yang G, Bachurski C, Kinsman S, et al. The transcription factor gene Nfib is essential for both lung maturation and brain development. Mol Cell Biol. 2005;25:685-98 pubmed
product information
Catalog Number :
MAB5272
Subcategory :
Neuroscience
Product Name :
Anti-Neural Cell Adhesion Molecule L1 Antibody, clone 324
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Gene ID :
P11627
Host Name :
Rat
Antigen :
Neural Cell Adhesion Molecule L1
Clone :
324
Conjugate :
Purified
Isotype :
IgG
Product Description :
Anti-Neural Cell Adhesion Molecule L1 Antibody, clone 324
Cross Reactivity :
Mouse;Rat
Background :
Families of adhesion molecules which share common carbohydrate domains do exist, despite the structural and functional diversity of these glycoproteins. These include the Ca2+-independent neural adhesion molecules: N-CAM, myelin associated glycoprotein (MAG) and L1. L1 is involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, cerebellar granule cell migration, neurite outgrowth on Schwann cells and interactions among epithelial cells of intestinal crypts
ALT Names :
CD171;N-CAM L1
Immunogen :
Rats were immunized with a glycoprotein fraction from cerebellum of 8-10 day old C57BL/6J mice.
Specificity :
Monoclonal antibody against neural cell adhesion molecule L1 from rat-rat hybrid cells.
Package Size :
100 μg
Uses :
Immunocytochemistry;Immunohistochemistry;Western Blotting
Storage :
Stable for 1 year at 2-8ºC from date of receipt.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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