Chromogranin A Antibody, clone LK2H10 | EMD Millipore MAB5268 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Chromogranin A Antibody, clone LK2H10

catalog :

MAB5268

quantity :

500 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

LK2H10

The same clone is also sold as:

OriGene: TA327660
Abnova: MAB16164, MAB11338
Novus Biologicals: NBP2-34672-0.1 mg, NBP2-44767, NBP2-32956-0.1mg
Abcam: ab53464
Santa Cruz Biotechnology: sc-47714
MyBioSource: MBS370046
Bio-Rad: MCA5696
Enzo Life Sciences: BML-CA2218-0025
Invitrogen: MA5-13096, MA5-13093
LifeSpan Biosciences: LS-C312014, LS-C348410, LS-C88080, LS-C188660, LS-C357818, LS-C22209, LS-C88081, LS-C84840, LS-C95316, LS-C84841, LS-C88079, LS-B5571

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 9

Reference
Yin Y, Xu L, Chang Y, Zeng T, Chen X, Wang A, et al. N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway. Mol Cancer. 2019;18:11 pubmed publisher
Kim J, Jin H, Zhao J, Yang Y, Li Y, Yang X, et al. FOXA1 inhibits prostate cancer neuroendocrine differentiation. Oncogene. 2017;36:4072-4080 pubmed publisher
Wyatt A, Mo F, Wang K, McConeghy B, Brahmbhatt S, Jong L, et al. Heterogeneity in the inter-tumor transcriptome of high risk prostate cancer. Genome Biol. 2014;15:426 pubmed publisher
Svensson C, Ceder J, Iglesias Gato D, Chuan Y, Pang S, Bjartell A, et al. REST mediates androgen receptor actions on gene repression and predicts early recurrence of prostate cancer. Nucleic Acids Res. 2014;42:999-1015 pubmed publisher
Perry K, Reynolds C, Rosen D, Edgerton M, T Albarracin C, Gilcrease M, et al. Metastatic neuroendocrine tumour in the breast: a potential mimic of in-situ and invasive mammary carcinoma. Histopathology. 2011;59:619-30 pubmed publisher
Rickman O, Vohra P, Sanyal B, Vrana J, Aubry M, Wigle D, et al. Analysis of ErbB receptors in pulmonary carcinoid tumors. Clin Cancer Res. 2009;15:3315-24 pubmed publisher
Akiyama T, Sadahira Y, Irei I, Nishimura H, Hida A, Notohara K, et al. Pancreatic serous microcystic adenoma with extensive oncocytic change. Pathol Int. 2009;59:102-6 pubmed publisher
Whitehead R, Robinson P. Establishment of conditionally immortalized epithelial cell lines from the intestinal tissue of adult normal and transgenic mice. Am J Physiol Gastrointest Liver Physiol. 2009;296:G455-60 pubmed publisher
Kirkland S, Ying H. Alpha2beta1 integrin regulates lineage commitment in multipotent human colorectal cancer cells. J Biol Chem. 2008;283:27612-9 pubmed publisher

product information

Catalog Number :

MAB5268

Subcategory :

Neuroscience

Product Name :

Anti-Chromogranin A Antibody, clone LK2H10

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P10645

Host Name :

Mouse

Antigen :

Chromogranin A

Clone :

LK2H10

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Chromogranin A Antibody, clone LK2H10

Cross Reactivity :

Human;Mouse;Monkey;Pig;Rat

Background :

Chromogranin A (a protein of 439 amino acids which is encoded on chromosome 14) is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, phenochromocytomas, paragangliomas, and other neuroendocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.

ALT Names :

CgA; Pituitary Secretory Protein I

Immunogen :

Human pheochromocytoma

Specificity :

Chromogranin, an acidic protein having a molecular weight of about 68 kDa abides in the polypeptide-hormone-containing secretory granules of human endocrine tissues. Anti-chromogranin A can be used to stain most normal and neoplastic endocrine tissues containing secretory granules (exceptions include cells from the hypothalamus and posterior pituitary, which are known to contain secretory granules). The amount of staining is usually proportional to the number of secretory granules present (1).

Package Size :

500 µg

Uses :

Immunohistochemistry;Immunohistochemistry (Paraffin);Western Blotting

Storage :

Stable for 6 months at 2-8ºC in undiluted aliquots from date of receipt.