Nerve Growth Factor Receptor (p75) Antibody, clone 8211 | EMD Millipore MAB5264 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Nerve Growth Factor Receptor (p75) Antibody, clone 8211

catalog :

MAB5264

quantity :

50 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8211

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 3

Reference
Granström A, Orrego A, Svensson P, Almström M, Skikuniene J, Wester T. Nerve growth factor receptor immunohistochemistry has a limited additional value to diagnose Hirschsprung's disease. Pediatr Surg Int. 2011;27:431-5 pubmed publisher
Rogers M, Bailey S, Matusica D, Nicholson I, Muyderman H, Pagadala P, et al. ProNGF mediates death of Natural Killer cells through activation of the p75NTR-sortilin complex. J Neuroimmunol. 2010;226:93-103 pubmed publisher
Perini G, Della Bianca V, Politi V, Della Valle G, Dal Pra I, Rossi F, et al. Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines. J Exp Med. 2002;195:907-18 pubmed

product information

Catalog Number :

MAB5264

Subcategory :

Neuroscience

Product Name :

Anti-Nerve Growth Factor Receptor (p75) Antibody, clone 8211

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P08138

Host Name :

Mouse

Antigen :

Nerve Growth Factor Receptor (p75)

Clone :

8211

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-Nerve Growth Factor Receptor (p75) Antibody, clone 8211

Cross Reactivity :

Human

Background :

The low affinity NGFR (Nerve growth factor receptor) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NGFR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death. It is expressed on many neuronal cells types including many embryonic forms and the receptor can be used to isolate neuronal progenitor cells.

ALT Names :

NGF-Receptor p75; Low Affinity NGF Receptor; NGFR

Immunogen :

Membrane fragments of the melanoma cell line WM-9 (Herlyn et al., 1983).

Specificity :

Reacts with NGF-receptors in human system.

Package Size :

50 μg

Uses :

Immunocytochemistry;Immunohistochemistry;Immunohistochemistry (Paraffin);Western Blotting

Storage :

Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.