This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name : 
EMD Millipore
other brands : 
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type : 
antibody
product name : 
Neurofilament 200 kDa Antibody, clone RT97
catalog : 
MAB5262
quantity : 
50 μg
clonality : 
monoclonal
host : 
mouse
conjugate : 
nonconjugated
clone name : 
RT97
The same clone is also sold as:
The same clone is also sold as:
- Developmental Studies Hybridoma Bank: RT97
- Novus Biologicals: NBP2-29435, NBP2-33062
- Bio-Rad: MCA1321GA
- US Biological: N2160-14, 138576
- LifeSpan Biosciences: LS-C357988, LS-C85343, LS-C57294
- Abnova: MAB11229
reactivity : 
human, mouse, rat
application : 
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 45
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| Gelpi E, Lladó A, Clarimon J, Rey M, Rivera R, Ezquerra M, et al. Phenotypic variability within the inclusion body spectrum of basophilic inclusion body disease and neuronal intermediate filament inclusion disease in frontotemporal lobar degenerations with FUS-positive inclusions. J Neuropathol Exp Neurol. 2012;71:795-805 pubmed  publisher  | |
| Raedt R, Pinxteren J, Van Dycke A, Waeytens A, Craeye D, Timmermans F, et al. Differentiation assays of bone marrow-derived Multipotent Adult Progenitor Cell (MAPC)-like cells towards neural cells cannot depend on morphology and a limited set of neural markers. Exp Neurol. 2007;203:542-54 pubmed  | |
| Nakao S, Uemura M, Aoki E, Suzuki S, Takeichi M, Hirano S. Distribution of OL-protocadherin in axon fibers in the developing chick nervous system. Brain Res Mol Brain Res. 2005;134:294-308 pubmed  | |
| Bampton E, Taylor J. Effects of Schwann cell secreted factors on PC12 cell neuritogenesis and survival. J Neurobiol. 2005;63:29-48 pubmed  | |
| Itoh K, Cheng L, Kamei Y, Fushiki S, Kamiguchi H, Gutwein P, et al. Brain development in mice lacking L1-L1 homophilic adhesion. J Cell Biol. 2004;165:145-54 pubmed  | 
product information
Catalog Number : 
MAB5262
Subcategory : 
Neuroscience
Product Name : 
Anti-Neurofilament 200 kDa Antibody, clone RT97
Product Type : 
Antibodies
Clonality : 
Monoclonal Antibody
Gene ID : 
P12036
Host Name : 
Mouse
Antigen : 
Neurofilament 200 kDa
Clone : 
RT97
Conjugate : 
Purified
Isotype : 
IgG1
Product Description : 
Anti-Neurofilament 200 kDa Antibody, clone RT97
Cross Reactivity : 
Human;Mouse;Rat
Background : 
Neurofilaments are a type of intermediate filament that serve as major elements of the cytoskeleton supporting the axon cytoplasm. They are the most abundant fibrillar components of the axon, being on average 3-10 times more frequent than axonal microtubules. Neurofilaments (10nm in dia.) are built from three intertwined protofibrils which are themselves composed of two tetrameric protofilament complexes of monomeric proteins. The neurofilament triplet proteins (68/70, 160, and 200 kDa) occur in both the central and peripheral nervous system and are usually neuron specific. The 68/70 kDa NF-L protein can self-assemble into a filamentous structure, however the 160 kDa NF-M and 200 kDa NF-H proteins require the presence of the 68/70 kDa NF-L protein to co-assemble. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas and neuroblastomas stain positively for neurofilaments. Although typically restricted to neurons, neurofilaments have been detected in paragangliomas and adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilaments. For more neurofilament information see Nervous System Cell Type Specific Marker chart online under the Millipore Technical Support section.
Immunogen : 
Rat brain protein preparation
Specificity : 
The antibody recognizes an epitope present on human neurofilaments 200 kDa and both bovine 160 kDa and 200 kDa neurofilaments (2). lt reacts with numerous neurites in human senile plaques and decorates neurofibrillary tangles (NFT) (i.e. on the pyramidal cells of the hippocampus and on neurons of the cerebral cortex of subjects with senile dementia of the Alzheimer’s type).
Package Size : 
50 μg
Uses : 
Immunohistochemistry;Immunohistochemistry (Paraffin);Western Blotting
Storage : 
Stable for 1 year at 2-8ºC from date of receipt.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany
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View all the new antibodies at www.emdmillipore.com.
Hundreds of New Antibodies in the areas of:
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