This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
Synaptophysin Antibody, clone SY38, Alexa Fluor® 488 Conjugate
catalog :
MAB5258A4
quantity :
100 µL
clonality :
monoclonal
host :
mouse
conjugate :
AF488
clone name :
SY38

The same clone is also sold as:
reactivity :
human, mouse, rat, bovine
application :
western blot, immunohistochemistry, immunocytochemistry
citations: 41
Published Application/Species/Sample/DilutionReference
  • western blot; rat
  • western blot; mouse; 1:10,000
Zhang P, Fu W, Fu A, Ip N. S-nitrosylation-dependent proteasomal degradation restrains Cdk5 activity to regulate hippocampal synaptic strength. Nat Commun. 2015;6:8665 pubmed publisher
  • immunocytochemistry; human; 1:100; fig 1
Sun Y, Florer J, Mayhew C, Jia Z, Zhao Z, Xu K, et al. Properties of neurons derived from induced pluripotent stem cells of Gaucher disease type 2 patient fibroblasts: potential role in neuropathology. PLoS ONE. 2015;10:e0118771 pubmed publisher
  • western blot; mouse; fig 5
Han M, Lin C, Meng S, Wang X. Proteomics analysis reveals overlapping functions of clustered protocadherins. Mol Cell Proteomics. 2010;9:71-83 pubmed publisher
Höllerhage M, Deck R, de Andrade A, Respondek G, Xu H, Rösler T, et al. Piericidin A aggravates Tau pathology in P301S transgenic mice. PLoS ONE. 2014;9:e113557 pubmed publisher
Smith S, Figley S, Schreyer D, Paterson P. Protein-energy malnutrition developing after global brain ischemia induces an atypical acute-phase response and hinders expression of GAP-43. PLoS ONE. 2014;9:e107570 pubmed publisher
Dixon Salazar T, Fourgeaud L, Tyler C, Poole J, Park J, Boulanger L. MHC class I limits hippocampal synapse density by inhibiting neuronal insulin receptor signaling. J Neurosci. 2014;34:11844-56 pubmed publisher
Moreno Piovano G, Varayoud J, Luque E, Ramos J. Long-term ovariectomy increases BDNF gene methylation status in mouse hippocampus. J Steroid Biochem Mol Biol. 2014;144 Pt B:243-52 pubmed publisher
Games D, Valera E, Spencer B, Rockenstein E, Mante M, Adame A, et al. Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models. J Neurosci. 2014;34:9441-54 pubmed publisher
Crescenzi R, Debrosse C, Nanga R, Reddy S, Haris M, Hariharan H, et al. In vivo measurement of glutamate loss is associated with synapse loss in a mouse model of tauopathy. Neuroimage. 2014;101:185-92 pubmed publisher
Rockenstein E, Nuber S, Overk C, Ubhi K, Mante M, Patrick C, et al. Accumulation of oligomer-prone ?-synuclein exacerbates synaptic and neuronal degeneration in vivo. Brain. 2014;137:1496-513 pubmed publisher
Williams P, Kim S, Martin J. Postnatal maturation of the red nucleus motor map depends on rubrospinal connections with forelimb motor pools. J Neurosci. 2014;34:4432-41 pubmed publisher
Oda S, Funato H, Sato F, Adachi Akahane S, Ito M, Takase K, et al. A subset of thalamocortical projections to the retrosplenial cortex possesses two vesicular glutamate transporter isoforms, VGluT1 and VGluT2, in axon terminals and somata. J Comp Neurol. 2014;522:2089-106 pubmed publisher
Shenton F, Pyner S. Expression of transient receptor potential channels TRPC1 and TRPV4 in venoatrial endocardium of the rat heart. Neuroscience. 2014;267:195-204 pubmed publisher
Sierksma A, Van den Hove D, Pfau F, Philippens M, Bruno O, Fedele E, et al. Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D. Neuropharmacology. 2014;77:120-30 pubmed publisher
Alexiou G, Moschovi M, Stefanaki K, Panagopoulos D, Tsotra M, Siozos G, et al. Supratentorial ependymomas in children: Analysis of nine cases. J Pediatr Neurosci. 2013;8:15-8 pubmed publisher
Nakajima C, Kulik A, Frotscher M, Herz J, Schafer M, Bock H, et al. Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes. J Biol Chem. 2013;288:21909-23 pubmed publisher
Larimore J, Ryder P, Kim K, Ambrose L, Chapleau C, Calfa G, et al. MeCP2 regulates the synaptic expression of a Dysbindin-BLOC-1 network component in mouse brain and human induced pluripotent stem cell-derived neurons. PLoS ONE. 2013;8:e65069 pubmed publisher
Stagni F, Magistretti J, Guidi S, Ciani E, Mangano C, Calza L, et al. Pharmacotherapy with fluoxetine restores functional connectivity from the dentate gyrus to field CA3 in the Ts65Dn mouse model of down syndrome. PLoS ONE. 2013;8:e61689 pubmed publisher
Bachstetter A, Rowe R, Kaneko M, Goulding D, Lifshitz J, Van Eldik L. The p38? MAPK regulates microglial responsiveness to diffuse traumatic brain injury. J Neurosci. 2013;33:6143-53 pubmed publisher
Garringer H, Murrell J, Sammeta N, Gnezda A, Ghetti B, Vidal R. Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice. PLoS ONE. 2013;8:e56426 pubmed publisher
Nakata Y, Yasuda T, Fukaya M, Yamamori S, Itakura M, Nihira T, et al. Accumulation of ?-synuclein triggered by presynaptic dysfunction. J Neurosci. 2012;32:17186-96 pubmed publisher
Mitchell D, Blasier K, Jeffery E, Ross M, Pullikuth A, Suo D, et al. Trk activation of the ERK1/2 kinase pathway stimulates intermediate chain phosphorylation and recruits cytoplasmic dynein to signaling endosomes for retrograde axonal transport. J Neurosci. 2012;32:15495-510 pubmed publisher
Bachstetter A, Norris C, Sompol P, Wilcock D, Goulding D, Neltner J, et al. Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology. J Neurosci. 2012;32:10201-10 pubmed publisher
Chao H, Lai Y, Lu Y, Lin C, Mai W, Huang Y. NMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3. Nucleic Acids Res. 2012;40:8484-98 pubmed
Wang C, Huang Y. Calpain 2 activated through N-methyl-D-aspartic acid receptor signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons. Mol Cell Biol. 2012;32:3321-32 pubmed publisher
Orozco D, Tahirovic S, Rentzsch K, Schwenk B, Haass C, Edbauer D. Loss of fused in sarcoma (FUS) promotes pathological Tau splicing. EMBO Rep. 2012;13:759-64 pubmed publisher
Nunes A, Amaral J, Lo A, Fonseca M, Viana R, Callaerts Vegh Z, et al. TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid-? deposition in APP/PS1 mice. Mol Neurobiol. 2012;45:440-54 pubmed publisher
Silasi G, Klahr A, Hackett M, Auriat A, Nichol H, Colbourne F. Prolonged therapeutic hypothermia does not adversely impact neuroplasticity after global ischemia in rats. J Cereb Blood Flow Metab. 2012;32:1525-34 pubmed publisher
Mandler M, Rockenstein E, Ubhi K, Hansen L, Adame A, Michael S, et al. Detection of peri-synaptic amyloid-? pyroglutamate aggregates in early stages of Alzheimer's disease and in A?PP transgenic mice using a novel monoclonal antibody. J Alzheimers Dis. 2012;28:783-94 pubmed publisher
Tang J, Mardini F, Caltagarone B, Garrity S, Li R, Bianchi S, et al. Anesthesia in presymptomatic Alzheimer's disease: a study using the triple-transgenic mouse model. Alzheimers Dement. 2011;7:521-531.e1 pubmed publisher
Bangasser D, Zhang X, Garachh V, Hanhauser E, Valentino R. Sexual dimorphism in locus coeruleus dendritic morphology: a structural basis for sex differences in emotional arousal. Physiol Behav. 2011;103:342-51 pubmed publisher
Peng W, Bao Y, Sawicki J. Epithelial cell-targeted transgene expression enables isolation of cyan fluorescent protein (CFP)-expressing prostate stem/progenitor cells. Transgenic Res. 2011;20:1073-86 pubmed publisher
Hao W, Liu Y, Liu S, Walter S, Grimm M, Kiliaan A, et al. Myeloid differentiation factor 88-deficient bone marrow cells improve Alzheimer's disease-related symptoms and pathology. Brain. 2011;134:278-92 pubmed publisher
Gil Bea F, Solas M, Mateos L, Winblad B, Ramirez M, Cedazo Minguez A. Cholinergic hypofunction impairs memory acquisition possibly through hippocampal Arc and BDNF downregulation. Hippocampus. 2011;21:999-1009 pubmed publisher
Kubinova S, Horak D, Kozubenko N, Vanecek V, Proks V, Price J, et al. The use of superporous Ac-CGGASIKVAVS-OH-modified PHEMA scaffolds to promote cell adhesion and the differentiation of human fetal neural precursors. Biomaterials. 2010;31:5966-75 pubmed publisher
Murray C, Sanderson D, Barkus C, Deacon R, Rawlins J, Bannerman D, et al. Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium. Neurobiol Aging. 2012;33:603-616.e3 pubmed publisher
Huttner A, Kieran M, Yao X, Cruz L, Ladner J, Quayle K, et al. Clinicopathologic study of glioblastoma in children with neurofibromatosis type 1. Pediatr Blood Cancer. 2010;54:890-6 pubmed publisher
Gottschall P, Ajmo J, Eakin A, Howell M, Mehta H, Bailey L. Panel of synaptic protein ELISAs for evaluating neurological phenotype. Exp Brain Res. 2010;201:885-93 pubmed publisher
Newell Litwa K, Chintala S, Jenkins S, Pare J, McGaha L, Smith Y, et al. Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus. J Neurosci. 2010;30:820-31 pubmed publisher
Paganoni S, Bernstein J, Ferreira A. Ror1-Ror2 complexes modulate synapse formation in hippocampal neurons. Neuroscience. 2010;165:1261-74 pubmed publisher
Salazar G, Falcon Perez J, Harrison R, Faundez V. SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity. PLoS ONE. 2009;4:e5896 pubmed publisher
product information
Catalog Number :
MAB5258A4
Subcategory :
Neuroscience
Product Name :
Anti-Synaptophysin Antibody, clone SY38, Alexa Fluor® 488 Conjugate
Product Type :
Antibodies
Gene ID :
P20488
Host Name :
Mouse
Antigen :
Synaptophysin
Clone :
SY38
Conjugate :
AlexaFluor®488
Isotype :
IgG1
Product Description :
Anti-Synaptophysin Antibody, clone SY38, Alexa Fluor® 488 Conjugate
Cross Reactivity :
Mouse;Human
Background :
Synaptophysin is a synaptic vesicle glycoprotein with four transmembrane domains weighing 38 kDa. It is present in neuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. The localization and ubiquitous expression of this protein in neuronal tissue makes it an excellent marker for neurons and neuroendocrine tumors. The gene for this protein is located on the X chromosome (Xp11.23-p11.22). The exact function of the protein is unknown: it interacts with the essential synaptic vesicle protein synaptobrevin, but when the synaptophysin gene is experimentally inactivated in animals, they still develop and function normally.
ALT Names :
Synaptophysin;Major synaptic vesicle protein p38
Immunogen :
Vesicular fraction of bovine brain
Specificity :
This antibody reacts with presynaptic vesicles of cerebral and spinal neurons, of neuromuscular endplates and with the retina of man, cow, rat and mouse. It also reacts with vesicles of adrenal medulla and islet cells.
Package Size :
100 µL
Uses :
Immunohistochemistry
Storage :
Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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