Neurofilament 200kDa Antibody, clone NE14, Alexa Fluor® 555 Conjugate | EMD Millipore MAB5256A5 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Neurofilament 200kDa Antibody, clone NE14, Alexa Fluor® 555 Conjugate

catalog :

MAB5256A5

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

Alexa Fluor 555

clone name :

NE14

The same clone is also sold as:

MilliporeSigma: SAB4200811, N5389
Novus Biologicals: NBP2-47834-0.1mg, NBP2-44728-0.1mg

reactivity :

human, mouse, rat

application :

immunohistochemistry, immunocytochemistry

citations: 3

Reference
Zhao X, Li D, Huang D, Song H, Mei H, Fang E, et al. Risk-Associated Long Noncoding RNA FOXD3-AS1 Inhibits Neuroblastoma Progression by Repressing PARP1-Mediated Activation of CTCF. Mol Ther. 2018;26:755-773 pubmed publisher
Lee H, Cho S, Moon I. The non-canonical effect of N-acetyl-D-glucosamine kinase on the formation of neuronal dendrites. Mol Cells. 2014;37:248-56 pubmed publisher
Bangratz M, Sarrazin N, Devaux J, Zambroni D, Echaniz Laguna A, Rene F, et al. A mouse model of Schwartz-Jampel syndrome reveals myelinating Schwann cell dysfunction with persistent axonal depolarization in vitro and distal peripheral nerve hyperexcitability when perlecan is lacking. Am J Pathol. 2012;180:2040-55 pubmed publisher

product information

Catalog Number :

MAB5256A5

Subcategory :

Neuroscience

Product Name :

Anti-Neurofilament 200kDa Antibody, clone NE14, Alexa Fluor® 555 Conjugate

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P12036

Host Name :

Mouse

Antigen :

Neurofilament 200kDa

Clone :

NE14

Conjugate :

AlexaFluor®555

Isotype :

IgG1

Product Description :

Anti-Neurofilament 200kDa Antibody, clone NE14, Alexa Fluor® 555 Conjugate

Cross Reactivity :

Rat;Mouse;Pig;Human

Background :

Neurofilaments are a type of intermediate filament that serve as major elements of the cytoskeleton supporting the axon cytoplasm. They are the most abundant fibrillar components of the axon, being on average 3-10 times more frequent than axonal microtubules. Neurofilaments (10nm in dia.) are built from three intertwined protofibrils which are themselves composed of two tetrameric protofilament complexs of monomeric proteins. The neurofilament triplet proteins (68/70, 160, and 200 kDa) occur in both the central and peripheral nervous system and are usually neuron specific. The 68/70 kDa NF-L protein can self-assemble into a filamentous structure, however the 160 kDa NF-M and 200 kDa NF-H proteins require the presence of the 68/70 kDa NF-L protein to co-assemble. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas and neuroblastomas stain positively for neurofilaments. Although typically restricted to neurons, neurofilaments have been detected in paragangliomas and adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilaments. For more neurofilament information and epitope maps, search "neurofilament" on our website.

ALT Names :

Neurofilament heavy polypeptide;NF-H;200 kDa neurofilament protein;Neurofilament triplet H protein

Immunogen :

Purified neurofilament polypeptides (Debus et al., 1983).

Package Size :

100 µL

Uses :

Immunocytochemistry;Immunohistochemistry

Storage :

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.