| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; mouse; loading ...; fig 1b
| Bustos V, Pulina M, Kelahmetoglu Y, Sinha S, Gorelick F, Flajolet M, et al. Bidirectional regulation of Aβ levels by Presenilin 1. Proc Natl Acad Sci U S A. 2017;114:7142-7147 pubmed publisher |
- western blot; human; fig 3
| Yamaguchi T, Yamauchi Y, Furukawa K, Ohmi Y, Ohkawa Y, Zhang Q, et al. Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing. Sci Rep. 2016;6:34505 pubmed publisher |
- western blot; mouse; 1:1000; fig 2a
| Sun M, Asghar S, Zhang H. The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb. Neurobiol Dis. 2016;93:1-11 pubmed publisher |
- immunoprecipitation; mouse; fig 4d
| Kuzuya A, Zoltowska K, Post K, Arimon M, Li X, Svirsky S, et al. Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta. BMC Biol. 2016;14:25 pubmed publisher |
- western blot; human; fig 2
| Chhibber Goel J, Coleman Vaughan C, Agrawal V, Sawhney N, Hickey E, Powell J, et al. γ-Secretase Activity Is Required for Regulated Intramembrane Proteolysis of Tumor Necrosis Factor (TNF) Receptor 1 and TNF-mediated Pro-apoptotic Signaling. J Biol Chem. 2016;291:5971-85 pubmed publisher |
- immunoprecipitation; hamsters; fig 3
- western blot; hamsters; fig 3
| Chen A, Kim S, Shepardson N, Patel S, Hong S, Selkoe D. Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis. J Cell Biol. 2015;211:1157-76 pubmed publisher |
- western blot; human; fig 2
- immunoprecipitation; mouse; fig 3
- western blot; mouse; fig 3
| Wang J, Lu R, Yang J, Li H, He Z, Jing N, et al. TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production. Nat Commun. 2015;6:8876 pubmed publisher |
- western blot; mouse; fig 3c
| Parsi S, Smith P, Goupil C, Dorval V, Hébert S. Preclinical Evaluation of miR-15/107 Family Members as Multifactorial Drug Targets for Alzheimer's Disease. Mol Ther Nucleic Acids. 2015;4:e256 pubmed publisher |
- western blot; rat; 1:1000
| Lundgren J, Ahmed S, Schedin Weiss S, Gouras G, Winblad B, Tjernberg L, et al. ADAM10 and BACE1 are localized to synaptic vesicles. J Neurochem. 2015;135:606-15 pubmed publisher |
- immunoprecipitation; mouse
| Arimon M, Takeda S, Post K, Svirsky S, Hyman B, Berezovska O. Oxidative stress and lipid peroxidation are upstream of amyloid pathology. Neurobiol Dis. 2015;84:109-19 pubmed publisher |
| Cheng X, Gao Y, Zhao Y, Cheng X. Sodium Chloride Increases Aβ Levels by Suppressing Aβ Clearance in Cultured Cells. PLoS ONE. 2015;10:e0130432 pubmed publisher |
| Inoue M, Hur J, Kihara T, Teranishi Y, Yamamoto N, Ishikawa T, et al. Human brain proteins showing neuron-specific interactions with γ-secretase. FEBS J. 2015;282:2587-99 pubmed publisher |
- immunohistochemistry - paraffin section; human
- immunoprecipitation; human
- western blot; human
| Chen W, Hsieh Y, Huang Y, Lin C, Lin Y, Liu Y, et al. G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation. Mol Neurobiol. 2015;52:1835-1849 pubmed publisher |
| Sullivan S, Dillon G, Sullivan J, Ho A. Mint proteins are required for synaptic activity-dependent amyloid precursor protein (APP) trafficking and amyloid ? generation. J Biol Chem. 2014;289:15374-83 pubmed publisher |
| Almenar Queralt A, Kim S, Benner C, Herrera C, Kang D, Garcia Bassets I, et al. Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation. J Biol Chem. 2013;288:35222-36 pubmed publisher |
- immunoprecipitation; human
- western blot; human
| Zhou S, Zhou H, Walian P, Jap B. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production. Proc Natl Acad Sci U S A. 2005;102:7499-504 pubmed |
| Petit D, Hitzenberger M, Lismont S, Zoltowska K, Ryan N, Mercken M, et al. Extracellular interface between APP and Nicastrin regulates Aβ length and response to γ-secretase modulators. EMBO J. 2019;: pubmed publisher |
| Arber C, Toombs J, Lovejoy C, Ryan N, Paterson R, Willumsen N, et al. Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta. Mol Psychiatry. 2019;: pubmed publisher |
| Wong E, Liao G, Chang J, Xu P, Li Y, Greengard P. GSAP modulates γ-secretase specificity by inducing conformational change in PS1. Proc Natl Acad Sci U S A. 2019;116:6385-6390 pubmed publisher |
| Ryskamp D, Wu L, Wu J, Kim D, Rammes G, Geva M, et al. Pridopidine stabilizes mushroom spines in mouse models of Alzheimer's disease by acting on the sigma-1 receptor. Neurobiol Dis. 2019;124:489-504 pubmed publisher |
| Zoltowska K, Maesako M, Meier J, Berezovska O. Novel interaction between Alzheimer's disease-related protein presenilin 1 and glutamate transporter 1. Sci Rep. 2018;8:8718 pubmed publisher |
| Merilahti J, Ojala V, Knittle A, Pulliainen A, Elenius K. Genome-wide screen of gamma-secretase-mediated intramembrane cleavage of receptor tyrosine kinases. Mol Biol Cell. 2017;28:3123-3131 pubmed publisher |
| Schedin Weiss S, Inoue M, Hromadkova L, Teranishi Y, Yamamoto N, Wiehager B, et al. Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with ?-secretase and regulates neuronal amyloid ?-peptide levels. Alzheimers Res Ther. 2017;9:57 pubmed publisher |
| Mori T, Koyama N, Tan J, Segawa T, Maeda M, Town T. Combination therapy with octyl gallate and ferulic acid improves cognition and neurodegeneration in a transgenic mouse model of Alzheimer's disease. J Biol Chem. 2017;292:11310-11325 pubmed publisher |
| Guix F, Sannerud R, Berditchevski F, Arranz A, Horré K, Snellinx A, et al. Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments. Mol Neurodegener. 2017;12:25 pubmed publisher |
| Zoltowska K, Maesako M, Lushnikova I, Takeda S, Keller L, Skibo G, et al. Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production. Mol Neurodegener. 2017;12:15 pubmed publisher |
| Szaruga M, Veugelen S, Benurwar M, Lismont S, Sepulveda Falla D, Lleo A, et al. Qualitative changes in human γ-secretase underlie familial Alzheimer's disease. J Exp Med. 2015;212:2003-13 pubmed publisher |
| Elad N, De Strooper B, Lismont S, Hagen W, Veugelen S, Arimon M, et al. The dynamic conformational landscape of gamma-secretase. J Cell Sci. 2015;128:589-98 pubmed |
| Zhang X, Hoey R, Koide A, Dolios G, Paduch M, Nguyen P, et al. A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of γ-secretase. J Biol Chem. 2014;289:34851-61 pubmed publisher |
| Mosser S, Alattia J, Dimitrov M, Matz A, Pascual J, Schneider B, et al. The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain. Hum Mol Genet. 2015;24:371-82 pubmed publisher |
| Acx H, Chávez Gutiérrez L, Serneels L, Lismont S, Benurwar M, Elad N, et al. Signature amyloid ? profiles are produced by different ?-secretase complexes. J Biol Chem. 2014;289:4346-55 pubmed publisher |
| Li Y, Lu S, Tsai C, Bohm C, Qamar S, Dodd R, et al. Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes. Structure. 2014;22:125-35 pubmed publisher |
| Schedin Weiss S, Inoue M, Teranishi Y, Yamamoto N, Karlstrom H, Winblad B, et al. Visualizing active enzyme complexes using a photoreactive inhibitor for proximity ligation--application on ?-secretase. PLoS ONE. 2013;8:e63962 pubmed publisher |
| Viswanathan J, Haapasalo A, Kurkinen K, Natunen T, Mäkinen P, Bertram L, et al. Ubiquilin-1 modulates ?-secretase-mediated ?-site cleavage in neuronal cells. Biochemistry. 2013;52:3899-912 pubmed publisher |
| He P, Li P, Hua Q, Liu Y, Staufenbiel M, Li R, et al. Chronic administration of anti-stroke herbal medicine TongLuoJiuNao reduces amyloidogenic processing of amyloid precursor protein in a mouse model of Alzheimer's disease. PLoS ONE. 2013;8:e58181 pubmed publisher |
| Steuble M, Diep T, Sch tzle P, Ludwig A, Tagaya M, Kunz B, et al. Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport. Biol Open. 2012;1:761-74 pubmed publisher |
| Li X, Uemura K, Hashimoto T, Nasser Ghodsi N, Arimon M, Lill C, et al. Neuronal activity and secreted amyloid ? lead to altered amyloid ? precursor protein and presenilin 1 interactions. Neurobiol Dis. 2013;50:127-34 pubmed publisher |
| Nishimura M, Nakamura S, Kimura N, Liu L, Suzuki T, Tooyama I. Age-related modulation of ?-secretase activity in non-human primate brains. J Neurochem. 2012;123:21-8 pubmed publisher |
| Teranishi Y, Hur J, Gu G, Kihara T, Ishikawa T, Nishimura T, et al. Erlin-2 is associated with active ?-secretase in brain and affects amyloid ?-peptide production. Biochem Biophys Res Commun. 2012;424:476-81 pubmed publisher |
| Takeo K, Watanabe N, Tomita T, Iwatsubo T. Contribution of the ?-secretase subunits to the formation of catalytic pore of presenilin 1 protein. J Biol Chem. 2012;287:25834-43 pubmed publisher |
| Cacquevel M, Aeschbach L, Houacine J, Fraering P. Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified ?-secretase complexes. PLoS ONE. 2012;7:e35133 pubmed publisher |
| Frykman S, Teranishi Y, Hur J, Sandebring A, Yamamoto N, Ancarcrona M, et al. Identification of two novel synaptic ?-secretase associated proteins that affect amyloid ?-peptide levels without altering Notch processing. Neurochem Int. 2012;61:108-18 pubmed publisher |
| Chávez Gutiérrez L, Bammens L, Benilova I, Vandersteen A, Benurwar M, Borgers M, et al. The mechanism of ?-Secretase dysfunction in familial Alzheimer disease. EMBO J. 2012;31:2261-74 pubmed publisher |
| Guix F, Wahle T, Vennekens K, Snellinx A, Chávez Gutiérrez L, Ill Raga G, et al. Modification of ?-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease. EMBO Mol Med. 2012;4:660-73 pubmed publisher |
| Gwon A, Park J, Arumugam T, Kwon Y, Chan S, Kim S, et al. Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer's disease. Aging Cell. 2012;11:559-68 pubmed publisher |
| Rahman M, Zhang Z, Mody A, Su D, Das H. Intraperitoneal injection of JNK-specific inhibitor SP600125 inhibits the expression of presenilin-1 and Notch signaling in mouse brain without induction of apoptosis. Brain Res. 2012;1448:117-28 pubmed publisher |
| Xiong Z, Hongmei Z, Lu S, Yu L. Curcumin mediates presenilin-1 activity to reduce β-amyloid production in a model of Alzheimer's Disease. Pharmacol Rep. 2011;63:1101-8 pubmed |
| Wei Z, Gabriel G, Rui L, Cao X, Pennington P, Chlan Fourney J, et al. Monoamine oxidase-A physically interacts with presenilin-1(M146V) in the mouse cortex. J Alzheimers Dis. 2012;28:403-22 pubmed publisher |
| Jung C, Fuhrmann M, Honarnejad K, Van Leuven F, Herms J. Role of presenilin 1 in structural plasticity of cortical dendritic spines in vivo. J Neurochem. 2011;119:1064-73 pubmed publisher |
| Van Humbeeck C, Cornelissen T, Hofkens H, Mandemakers W, Gevaert K, De Strooper B, et al. Parkin interacts with Ambra1 to induce mitophagy. J Neurosci. 2011;31:10249-61 pubmed publisher |
| Bammens L, Chávez Gutiérrez L, Tolia A, Zwijsen A, De Strooper B. Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex. J Biol Chem. 2011;286:12271-82 pubmed publisher |
| Frånberg J, Svensson A, Winblad B, Karlstrom H, Frykman S. Minor contribution of presenilin 2 for ?-secretase activity in mouse embryonic fibroblasts and adult mouse brain. Biochem Biophys Res Commun. 2011;404:564-8 pubmed publisher |
| De Gasperi R, Sosa M, Dracheva S, Elder G. Presenilin-1 regulates induction of hypoxia inducible factor-1?: altered activation by a mutation associated with familial Alzheimer's disease. Mol Neurodegener. 2010;5:38 pubmed publisher |
| Zhang H, Sun S, Herreman A, De Strooper B, Bezprozvanny I. Role of presenilins in neuronal calcium homeostasis. J Neurosci. 2010;30:8566-80 pubmed publisher |
| Watanabe N, Takagi S, Tominaga A, Tomita T, Image Image I, Iwatsubo T, et al. Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase. J Biol Chem. 2010;285:19738-46 pubmed publisher |
| Frånberg J, Karlstrom H, Winblad B, Tjernberg L, Frykman S. gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes. PLoS ONE. 2010;5:e9772 pubmed publisher |
| Wu F, Schweizer C, Rudinskiy N, Taylor D, Kazantsev A, Luthi Carter R, et al. Novel gamma-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1. FASEB J. 2010;24:2464-74 pubmed publisher |
| Placanica L, Chien J, Li Y. Characterization of an atypical gamma-secretase complex from hematopoietic origin. Biochemistry. 2010;49:2796-804 pubmed publisher |
| Chen A, Guo L, Ostaszewski B, Selkoe D, LaVoie M. Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates. J Biol Chem. 2010;285:11378-91 pubmed publisher |
| Frykman S, Hur J, Frånberg J, Aoki M, Winblad B, Nahalkova J, et al. Synaptic and endosomal localization of active gamma-secretase in rat brain. PLoS ONE. 2010;5:e8948 pubmed publisher |
| Teranishi Y, Hur J, Welander H, Frånberg J, Aoki M, Winblad B, et al. Affinity pulldown of ?-secretase and associated proteins from human and rat brain. J Cell Mol Med. 2010;14:2675-86 pubmed publisher |
| Nahalkova J, Volkmann I, Aoki M, Winblad B, Bogdanovic N, Tjernberg L, et al. CD147, a gamma-secretase associated protein is upregulated in Alzheimer's disease brain and its cellular trafficking is affected by presenilin-2. Neurochem Int. 2010;56:67-76 pubmed publisher |
| Nielsen A. The coat protein complex II, COPII, protein Sec13 directly interacts with presenilin-1. Biochem Biophys Res Commun. 2009;388:571-5 pubmed publisher |
| Seo J, Kim T, Leem Y, Lee K, Park S, Baek I, et al. SK-PC-B70M confers anti-oxidant activity and reduces Abeta levels in the brain of Tg2576 mice. Brain Res. 2009;1261:100-8 pubmed publisher |
| Placanica L, Zhu L, Li Y. Gender- and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease. PLoS ONE. 2009;4:e5088 pubmed publisher |
| Placanica L, Tarassishin L, Yang G, Peethumnongsin E, Kim S, Zheng H, et al. Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes. J Biol Chem. 2009;284:2967-77 pubmed publisher |
| Hur J, Welander H, Behbahani H, Aoki M, Frånberg J, Winblad B, et al. Active gamma-secretase is localized to detergent-resistant membranes in human brain. FEBS J. 2008;275:1174-87 pubmed publisher |
| Fuso A, Cavallaro R, Zampelli A, D Anselmi F, Piscopo P, Confaloni A, et al. gamma-Secretase is differentially modulated by alterations of homocysteine cycle in neuroblastoma and glioblastoma cells. J Alzheimers Dis. 2007;11:275-90 pubmed |
| Frånberg J, Welander H, Aoki M, Winblad B, Tjernberg L, Frykman S. Rat brain gamma-secretase activity is highly influenced by detergents. Biochemistry. 2007;46:7647-54 pubmed |
| Haapasalo A, Kim D, Carey B, Turunen M, Pettingell W, Kovacs D. Presenilin/gamma-secretase-mediated cleavage regulates association of leukocyte-common antigen-related (LAR) receptor tyrosine phosphatase with beta-catenin. J Biol Chem. 2007;282:9063-72 pubmed |
| Caballero C, Jimenez S, Moreno Gonzalez I, Baglietto Vargas D, Sanchez Varo R, Gavilan M, et al. Inter-individual variability in the expression of the mutated form of hPS1M146L determined the production of Abeta peptides in the PS1xAPP transgenic mice. J Neurosci Res. 2007;85:787-97 pubmed |
| Sato C, Morohashi Y, Tomita T, Iwatsubo T. Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines. J Neurosci. 2006;26:12081-8 pubmed |
| Kuzuya A, Uemura K, Kitagawa N, Aoyagi N, Kihara T, Ninomiya H, et al. Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1). J Neurosci Res. 2007;85:153-65 pubmed |
| Oh Y, Turner R. Protease digestion indicates that endogenous presenilin 1 is present in at least two physical forms. Biochem Biophys Res Commun. 2006;346:330-4 pubmed |
| Ogura T, Mio K, Hayashi I, Miyashita H, Fukuda R, Kopan R, et al. Three-dimensional structure of the gamma-secretase complex. Biochem Biophys Res Commun. 2006;343:525-34 pubmed |
| Uchihara T, Sanjo N, Nakamura A, Han K, Song S, St George Hyslop P, et al. Transient abundance of presenilin 1 fragments/nicastrin complex associated with synaptogenesis during development in rat cerebellum. Neurobiol Aging. 2006;27:88-97 pubmed |
| Watanabe N, Tomita T, Sato C, Kitamura T, Morohashi Y, Iwatsubo T. Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1. J Biol Chem. 2005;280:41967-75 pubmed |
| Laudon H, Hansson E, Melén K, Bergman A, Farmery M, Winblad B, et al. A nine-transmembrane domain topology for presenilin 1. J Biol Chem. 2005;280:35352-60 pubmed |
