Caspase 8 Antibody, clone 1-1-37 | EMD Millipore MAB4708 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Caspase 8 Antibody, clone 1-1-37

catalog :

MAB4708

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1-1-37

reactivity :

human

application :

western blot

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 1	Linderoth E, Pilia G, Mahajan N, Ferby I. Activated Cdc42-associated kinase 1 (Ack1) is required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor recruitment to lipid rafts and induction of cell death. J Biol Chem. 2013;288:32922-31 pubmed publisher
	Brugnon F, Pons Rejraji H, Artonne C, Janny L, Grizard G. The limits for detection of activated caspases of spermatozoa by western blot in human semen. Andrologia. 2012;44:265-72 pubmed publisher
	Rodriguez Acebes S, Proctor I, Loddo M, Wollenschlaeger A, Rashid M, Falzon M, et al. Targeting DNA replication before it starts: Cdc7 as a therapeutic target in p53-mutant breast cancers. Am J Pathol. 2010;177:2034-45 pubmed publisher

product information

Catalog Number :

MAB4708

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Caspase 8 Antibody, clone 1-1-37

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q14790

Host Name :

Mouse

Antigen :

Caspase 8

Clone :

1-1-37

Conjugate :

Purified

Isotype :

Product Description :

Anti-Caspase 8 Antibody, clone 1-1-37

Cross Reactivity :

Human

Background :

Caspase-8 is a 55 kDa protein that binds to the death effector domain (DED) of FADD through an analogous DED domain present in the proform of caspase-8. Recruitment of caspase-8 to the Fas receptor results in oligomerization of the caspase-8 protein, which drives its auto-activation through self-cleavage. Active caspase-8 then proteolytically activates other downstream caspases including caspase-9, which lead to cell death.

ALT Names :

MACH1; FLICE

Immunogen :

Recombinant full-length human caspase-8 protein

Specificity :

Highly specific to caspase-8 and shows no cross-reaction with other caspase family members. This antibody recognizes the full length 55kDa caspase 8 on western blots.

Package Size :

100 µg

Uses :

Western Blotting

Storage :

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.