Survivin Antibody, clone 8E2 | EMD Millipore MAB4617 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Survivin Antibody, clone 8E2

catalog :

MAB4617

quantity :

50 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8E2

The same clone is also sold as:

LifeSpan Biosciences: LS-C180566, LS-C179997, LS-C180565, LS-C87607, LS-C180567, LS-C180564, LS-C87606
Invitrogen: MA5-11680
Santa Cruz Biotechnology: sc-47750

reactivity :

human

application :

immunocytochemistry

product information

Catalog Number :

MAB4617

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Survivin Antibody, clone 8E2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O15392

Host Name :

Mouse

Antigen :

Survivin

Clone :

8E2

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-Survivin Antibody, clone 8E2

Cross Reactivity :

Human

Background :

Survivin, an inhibitor of apoptosis (IAP) protein, is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. It indicates that survivin may counteract a default induction of apoptosis in G2/M phase. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favor aberrant progression of transformed cells through mitosis.

ALT Names :

TIAP

Immunogen :

Full length recombinant human survivin

Specificity :

MAB4617 detects human survivin (16.5 kDa).

Package Size :

50 µg

Uses :

ELISA;Immunofluorescence

Storage :

Maintain at 2-8°C for up to 12 months.