PDX-1 Antibody, clone 6F6.1 | EMD Millipore MAB4425 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PDX-1 Antibody, clone 6F6.1

catalog :

MAB4425

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6F6.1

reactivity :

human

application :

western blot

product information

Catalog Number :

MAB4425

Subcategory :

Stem Cell Research

Product Name :

Anti-PDX-1 Antibody, clone 6F6.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P52945

Host Name :

Mouse

Antigen :

PDX-1

Clone :

6F6.1

Conjugate :

Purified

Isotype :

IgG2bκ

Product Description :

Anti-PDX-1 Antibody, clone 6F6.1

Cross Reactivity :

Human

Background :

Pancreas/duodenum homeobox protein 1 (PDX-1) belongs to the homeodomain-containing transcription factor family. PDX-1 is a critical factor in the processes of development and differentiation of the pancreas, specifically through the designation of early pancreatic epithelium, allowing it to proliferate, branch and ultimately differentiate. It has been shown to stimulate gene transcription for insulin, islet amyloid polypeptide, glucokinase, glucose transporter type 2, and somatostatin. PDX-1 also serves to regulate beta cells past development and into the adult stage. Defects in PDX-1 are the cause of several pancreatic diseases including; pancreatic agenesis, maturity-onset diabetes of the young type 4, and non-insulin-dependent diabetes mellitus. Up-regulation of PDX-1 in adult tissue has been associated with pancreatitis and pancreatic cancer. PDX-1 is expressed in the duodenum and pancreas tissues. It is also found in pancreatic progenitor cells.

ALT Names :

Pancreas Duodenum Homeobox-1;insulin promoter factor 1, homeodomain transcription factor;pancreatic-duodenal homeobox factor 1;pancreas/duodenum homeobox protein 1;Insulin upstream factor 1;Glucose-sensitive factor;somatostatin transcription factor 1;Somatostatin-transactivating factor 1;Insulin promoter factor 1;Islet/duodenum homeobox-1

Immunogen :

GST-tagged recombinant protein corresponding to human PDX-1.

Package Size :

100 µL

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt