SOX-2 Antibody, clone 10H9.1, Alexa Fluor® 488 conjugate | EMD Millipore MAB4423A4 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

SOX-2 Antibody, clone 10H9.1, Alexa Fluor® 488 conjugate

catalog :

MAB4423A4

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

AF488

clone name :

10H9.1

reactivity :

human, mouse

application :

immunocytochemistry

product information

Catalog Number :

MAB4423A4

Subcategory :

Stem Cell Research

Product Name :

Anti-SOX-2 Antibody, clone 10H9.1, Alexa Fluor® 488 conjugate

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P48431

Host Name :

Mouse

Antigen :

SOX-2

Conjugate :

AlexaFluor®488

Isotype :

IgG2bκ

Product Description :

Anti-SOX-2 Antibody, clone 10H9.1, Alexa Fluor® 488 conjugate

Cross Reactivity :

Human;Mouse

Background :

SOX-2 is also known as SRY related HMG BOX gene 2. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX1, SOX2 and SOX3 show the closest homology to SRY. They share maximum homology within the HMG domain and are expressed mainly in the developing nervous system of the mouse. These genes share significant homology outside the HMG box also and are highly conserved throughout their evolution. Sox-2 plays a key role in embryonic stem cell development, and has been shown to help stem cells maintain a pluripotent potential. It has also been shown to be associated with uncommitted dividing stem cell and precursor cells of the developing CNS. SOX-2 has been identified as a key transcription factor required for cellular reprogramming.

ALT Names :

SOX2;ANOP3;MCOPS3;MGC2413;SRY related HMG BOX gene 2

Immunogen :

recombinant protein corresponding to human SOX-2.

Package Size :

100 µL

Uses :

Immunocytochemistry

Storage :

Maintain refrigerated at 2-8ºC protected from light in undiluted aliquots for up to 6 months from date of receipt.