SOX-2 Antibody, clone 10H9.1 | EMD Millipore MAB4423 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

SOX-2 Antibody, clone 10H9.1

catalog :

MAB4423

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

10H9.1

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:250; loading ...; fig 1h western blot; human; 1:2000; loading ...; fig s4h	Mollaoglu G, Jones A, Wait S, Mukhopadhyay A, Jeong S, Arya R, et al. The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment. Immunity. 2018;49:764-779.e9 pubmed publisher

product information

Catalog Number :

MAB4423

Subcategory :

Stem Cell Research

Product Name :

Anti-SOX-2 Antibody, clone 10H9.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P48431

Host Name :

Mouse

Antigen :

SOX-2

Clone :

10H9.1

Conjugate :

Purified

Isotype :

IgG2bκ

Product Description :

Anti-SOX-2 Antibody, clone 10H9.1

Cross Reactivity :

Mouse;Human

Background :

SOX 2 is also known as SRY related HMG BOX gene 2. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX1, SOX2 and SOX3 show the closest homology to SRY. They share maximum homology within the HMG domain and are expressed mainly in the developing nervous system of the mouse. These genes share significant homology outside the HMG box also and are highly conserved throughout their evolution. Sox-2 plays a key role in embryonic stem cell development, and has been shown to help stem cells maintain a pluripotent potential. It has also been shown to be associated with uncommitted dividing stem cell and precursor cells of the developing CNS.

ALT Names :

ANOP3;MCOPS3;MGC2413

Immunogen :

Recombinant protein corresponding to human SOX-2.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt