Achaete Scute homolog 2 Antibody, clone 8F1 | EMD Millipore MAB4417 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Achaete Scute homolog 2 Antibody, clone 8F1

catalog :

MAB4417

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8F1

reactivity :

human, mouse

application :

western blot, immunohistochemistry

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; fig 2a	Kim S, Kwon J, Park J, Seo H, Jung K, Moon Y, et al. Achaete-scute complex homologue 2 accelerates the development of Sjögren's syndrome-like disease in the NOD/ShiLtJ mouse. Immunol Lett. 2017;190:26-33 pubmed publisher
	Oh McGinnis R, Bogutz A, Lefebvre L. Partial loss of Ascl2 function affects all three layers of the mature placenta and causes intrauterine growth restriction. Dev Biol. 2011;351:277-86 pubmed publisher

product information

Catalog Number :

MAB4417

Subcategory :

Stem Cell Research

Product Name :

Anti-Achaete Scute homolog 2 Antibody, clone 8F1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O35885

Host Name :

Mouse

Antigen :

Achaete Scute homolog 2

Clone :

8F1

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Achaete Scute homolog 2 Antibody, clone 8F1

Cross Reactivity :

Human;Mouse

Background :

Achaete Scute homolog 2 (also known as mammalian aschaete-scute homolog 2 or Mash2) is a nuclear protein expressed specifically in the extravillous trophoblasts of developing placenta. Placental development involves control by the basic helix-loop-helix transcription factor Achaete Scute homolog 2, which may regulate HIF (hypoxia) in the formation of spongiotrophoblasts. Targeted mutagenesis of Achaete Scute homolog 2 yielded loss of function results in embryonic lethality at midgestation due to placental failure associated with a lack of spongiotrophoblasts and reduced labyrinthine trophoblast layers. In addition to healthy placental development, Achaete Scute proteins may also be involved in the determination of neuronal precursors in the central and peripheral nervous systems. Achaete Scute homolog 2 has also been implicated as a controller of intestinal stem cell fate and is essential for the maintenance of adult intestinal stem cells (Tanaka, M., et al., (1997) Dev Biol. 190(10):55-65).

ALT Names :

achaete-scute complex (Drosophila) homolog-like 2;achaete-scute complex homolog 2 (Drosophila);achaete-scute complex homolog-like 2;achaete-scute complex-like 2;achaete-scute complex-like 2 (Drosophila);mammalian achaete/scute homologue 2

Immunogen :

His-tagged recombinant protein corresponding to mouse Achaete Scute homolog 2.

Specificity :

This antibody recognizes Achaete Scute homolog 2.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt