This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
Oct-4 Antibody, clone 10H11.2
catalog :
MAB4401
quantity :
100 μg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
10H11.2
reactivity :
human, mouse, domestic rabbit
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry
citations: 40
Published Application/Species/Sample/Dilution | Reference |
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| Sang C, Cao X, Chen F, Yang X, Zhang Y. Differential Characterization of Two Kinds of Stem Cells Isolated from Rabbit Nucleus Pulposus and Annulus Fibrosus. Stem Cells Int. 2016;2016:8283257 pubmed
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| Pacheco L, Gomez L, Dias J, Ziebarth N, Howard G, Schiller P. Progerin expression disrupts critical adult stem cell functions involved in tissue repair. Aging (Albany NY). 2014;6:1049-63 pubmed
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| Muchkaeva I, Dashinimaev E, Artyuhov A, Myagkova E, Vorotelyak E, Yegorov Y, et al. Generation of iPS Cells from Human Hair Follice Dermal Papilla Cells. Acta Naturae. 2014;6:45-53 pubmed
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Chumarina M, Russ K, Azevedo C, Heuer A, Pihl M, Collin A, et al. Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene. Acta Neuropathol Commun. 2019;7:208 pubmed publisher
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Vega S, Liu E, Patel P, Kulesa A, Carlson A, Ma Y, et al. High-content imaging-based screening of microenvironment-induced changes to stem cells. J Biomol Screen. 2012;17:1151-62 pubmed
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Wang Y, Meng L, Hu H, Zhang Y, Zhao C, Li Q, et al. Oct-4B isoform is differentially expressed in breast cancer cells: hypermethylation of regulatory elements of Oct-4A suggests an alternative promoter and transcriptional start site for Oct-4B transcription. Biosci Rep. 2011;31:109-15 pubmed publisher
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product information
Catalog Number :
MAB4401
Subcategory :
Stem Cell Research
Product Name :
Anti-Oct-4 Antibody, clone 10H11.2
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Gene ID :
Q01860
Host Name :
Mouse
Antigen :
Oct 4
Clone :
clone 10H11.2
Conjugate :
Purified
Isotype :
IgG1
Product Description :
Anti-Oct-4 Antibody, clone 10H11.2
Cross Reactivity :
Human
Background :
Octamer-4 (Oct-4), a member of the POU family of transcription factors, has been demonstrated to be vital for the formation of self-renewing pluripotent stem cells. During embryogenesis expression of Oct-4 is limited to pluripotent cells of the inner cell mass (ICM) that contribute to the formation of all fetal cell types. This relationship between Oct-4 and pluripotency has seen this transcription factor emerge as a marker of pluripotent stem cells. Undifferentiated human and murine pluripotent Embryonic Stem (ES) and Embryonic Carcinoma (EC) cells express Oct-4. Additionally, murine Embryonic Germ (EG) cells are also known to express Oct-4. Following stem cell differentiation, the level of Oct-4 expression decreases. Oct-4 expression by human EG cells is not known.
ALT Names :
Octamer-binding transcription factor 3;POU class 5 homeobox 1;POU domain class 5, transcription factor 1;POU domain, class 5, transcription factor 1;POU-type homeodomain-containing DNA-binding protein;octamer-binding transcription factor-3
Immunogen :
Recombinant GST fusion protein, human Oct-4 (aa 1-134).
Specificity :
Reacts with human Oct-4 only, and detects the Oct-4A isoform. (Note: Please order Catalog No. MAB4419 for use with mouse embryonic stem cells).
Package Size :
100 μg
Uses :
Western Blotting;Flow Cytometry;Immunocytochemistry;ELISA
Storage :
Stable for 1 year at from date of receipt.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany
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