This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
SOX-2 Antibody
catalog :
MAB4343
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
6F1.2
reactivity :
human, mouse, bovine, pigs
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 37
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:200; loading ...; fig 5b
Urata S, Iida T, Yamamoto M, Mizushima Y, Fujimoto C, Matsumoto Y, et al. Cellular cartography of the organ of Corti based on optical tissue clearing and machine learning. elife. 2019;8: pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 1f
Jung Klawitter S, Ebersold J, Göhring G, Blau N, Opladen T. Generation of an iPSC line from a patient with GTP cyclohydrolase 1 (GCH1) deficiency: HDMC0061i-GCH1. Stem Cell Res. 2017;20:38-41 pubmed publisher
  • western blot; mouse; loading ...; fig 2d
Po A, Begalli F, Abballe L, Alfano V, Besharat Z, Catanzaro G, et al. ?-Arrestin1/miR-326 Transcription Unit Is Epigenetically Regulated in Neural Stem Cells Where It Controls Stemness and Growth Arrest. Stem Cells Int. 2017;2017:5274171 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 5b
Li S, Zang Z, He J, Chen X, Yu S, Pei Y, et al. Expression of pannexin 1 and 2 in cortical lesions from intractable epilepsy patients with focal cortical dysplasia. Oncotarget. 2017;8:6883-6895 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 1d
Jung Klawitter S, Blau N, Sebe A, Ebersold J, Göhring G, Opladen T. Generation of an iPSC line from a patient with tyrosine hydroxylase (TH) deficiency: TH-1 iPSC. Stem Cell Res. 2016;17:580-583 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 5b
Li Y, Tzatzalos E, Kwan K, Grumet M, Cai L. Transcriptional Regulation of Notch1 Expression by Nkx6.1 in Neural Stem/Progenitor Cells during Ventral Spinal Cord Development. Sci Rep. 2016;6:38665 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:50; fig 5
Zak M, van Oort T, Hendriksen F, Garcia M, Vassart G, Grolman W. LGR4 and LGR5 Regulate Hair Cell Differentiation in the Sensory Epithelium of the Developing Mouse Cochlea. Front Cell Neurosci. 2016;10:186 pubmed publisher
  • immunocytochemistry; human; 1:500; fig 1
Momcilovic O, Sivapatham R, Oron T, Meyer M, Mooney S, Rao M, et al. Derivation, Characterization, and Neural Differentiation of Integration-Free Induced Pluripotent Stem Cell Lines from Parkinson's Disease Patients Carrying SNCA, LRRK2, PARK2, and GBA Mutations. PLoS ONE. 2016;11:e0154890 pubmed publisher
  • immunocytochemistry; mouse; 1:200; fig 3
  • western blot; mouse; 1:1000; fig 3
Moshfegh C, Aires L, Kisielow M, Vogel V. A gonogenic stimulated transition of mouse embryonic stem cells with enhanced control of diverse differentiation pathways. Sci Rep. 2016;6:25104 pubmed publisher
  • immunocytochemistry; bovine; 1:200
Park S, Kim D, Jung Y, Roh S. Thiazovivin, a Rho kinase inhibitor, improves stemness maintenance of embryo-derived stem-like cells under chemically defined culture conditions in cattle. Anim Reprod Sci. 2015;161:47-57 pubmed publisher
  • immunocytochemistry; mouse; 1:100
Deng S, Zhang Y, Xu C, Ma D. MicroRNA-125b-2 overexpression represses ectodermal differentiation of mouse embryonic stem cells. Int J Mol Med. 2015;36:355-62 pubmed publisher
  • immunocytochemistry; human; fig 1
Poletti V, Delli Carri A, Malagoli Tagliazucchi G, Faedo A, Petiti L, Mazza E, et al. Genome-Wide Definition of Promoter and Enhancer Usage during Neural Induction of Human Embryonic Stem Cells. PLoS ONE. 2015;10:e0126590 pubmed publisher
  • immunocytochemistry; human
Sivapatham R, Zeng X. Generation and Characterization of Patient-Specific Induced Pluripotent Stem Cell for Disease Modeling. Methods Mol Biol. 2016;1353:25-44 pubmed publisher
  • immunocytochemistry; human; 1:200
Wilson P, Payne T. Genetic reprogramming of human amniotic cells with episomal vectors: neural rosettes as sentinels in candidate selection for validation assays. Peerj. 2014;2:e668 pubmed publisher
  • western blot; pigs ; 1:200
Uh K, Park C, Choi K, Park J, Jeong Y, Roh S, et al. Analysis of imprinted IGF2/H19 gene methylation and expression in normal fertilized and parthenogenetic embryonic stem cells of pigs. Anim Reprod Sci. 2014;147:47-55 pubmed publisher
  • immunocytochemistry; human; 1:400
Wang L, Zhu H, Wu J, Li N, Hua J. Characterization of embryonic stem-like cells derived from HEK293T cells through miR302/367 expression and their potentiality to differentiate into germ-like cells. Cytotechnology. 2014;66:729-40 pubmed publisher
  • immunohistochemistry; mouse; 1:250
Momcilovic O, Liu Q, Swistowski A, Russo Tait T, Zhao Y, Rao M, et al. Genome wide profiling of dopaminergic neurons derived from human embryonic and induced pluripotent stem cells. Stem Cells Dev. 2014;23:406-20 pubmed publisher
Hepburn A, Steele R, Veeratterapillay R, Wilson L, Kounatidou E, Barnard A, et al. The induction of core pluripotency master regulators in cancers defines poor clinical outcomes and treatment resistance. Oncogene. 2019;38:4412-4424 pubmed publisher
Meyer K, Feldman H, Lu T, Drake D, Lim E, Ling K, et al. REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease. Cell Rep. 2019;26:1112-1127.e9 pubmed publisher
Wang S, Liu Z, Ye Y, Li B, Liu T, Zhang W, et al. Ectopic hTERT expression facilitates reprograming of fibroblasts derived from patients with Werner syndrome as a WS cellular model. Cell Death Dis. 2018;9:923 pubmed publisher
Miele E, Po A, Begalli F, Antonucci L, Mastronuzzi A, Marras C, et al. β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells. BMC Cancer. 2017;17:488 pubmed publisher
Beaudet M, Yang Q, Cadau S, Blais M, Bellenfant S, Gros Louis F, et al. High yield extraction of pure spinal motor neurons, astrocytes and microglia from single embryo and adult mouse spinal cord. Sci Rep. 2015;5:16763 pubmed publisher
Li H, Zhong X, Chau K, Santistevan N, Guo W, Kong G, et al. Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway. Nat Commun. 2014;5:5601 pubmed publisher
Watanabe M, Terasawa M, Miyano K, Yanagihara T, Uruno T, Sanematsu F, et al. DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation. J Immunol. 2014;193:5660-7 pubmed publisher
Taha M, Javeri A, Rohban S, Mowla S. Upregulation of pluripotency markers in adipose tissue-derived stem cells by miR-302 and leukemia inhibitory factor. Biomed Res Int. 2014;2014:941486 pubmed publisher
Scardigli R, Capelli P, Vignone D, Brandi R, Ceci M, La Regina F, et al. Neutralization of nerve growth factor impairs proliferation and differentiation of adult neural progenitors in the subventricular zone. Stem Cells. 2014;32:2516-28 pubmed publisher
Mastronuzzi A, Miele E, Po A, Antonelli M, Buttarelli F, Colafati G, et al. Large cell anaplastic medulloblastoma metastatic to the scalp: tumor and derived stem-like cells features. BMC Cancer. 2014;14:262 pubmed publisher
Chou Y, Lee C, Hsiao S, Lin S, Lin S, Chung C, et al. The emerging role of SOX2 in cell proliferation and survival and its crosstalk with oncogenic signaling in lung cancer. Stem Cells. 2013;31:2607-19 pubmed publisher
Pan Y, Wang W, Xia Z. Assessment of adult neurogenesis in mice. Curr Protoc Toxicol. 2013;Chapter 12:Unit12.20 pubmed publisher
Tian C, Liu Q, Ma K, Wang Y, Chen Q, Ambroz R, et al. Characterization of induced neural progenitors from skin fibroblasts by a novel combination of defined factors. Sci Rep. 2013;3:1345 pubmed publisher
Vega S, Liu E, Patel P, Kulesa A, Carlson A, Ma Y, et al. High-content imaging-based screening of microenvironment-induced changes to stem cells. J Biomol Screen. 2012;17:1151-62 pubmed
Tan G, Krammer F, Eggink D, Kongchanagul A, Moran T, Palese P. A pan-H1 anti-hemagglutinin monoclonal antibody with potent broad-spectrum efficacy in vivo. J Virol. 2012;86:6179-88 pubmed publisher
Low J, Blosser W, Dowless M, Ricci Vitiani L, Pallini R, De Maria R, et al. Knockdown of ubiquitin ligases in glioblastoma cancer stem cells leads to cell death and differentiation. J Biomol Screen. 2012;17:152-62 pubmed publisher
Sung L, Chang C, Amano T, Lin C, Amano M, Treaster S, et al. Efficient derivation of embryonic stem cells from nuclear transfer and parthenogenetic embryos derived from cryopreserved oocytes. Cell Reprogram. 2010;12:203-11 pubmed publisher
Low J, Dowless M, Shiyanova T, Rowlinson S, Ricci Vitiani L, De Maria R, et al. Knockdown of cancer testis antigens modulates neural stem cell marker expression in glioblastoma tumor stem cells. J Biomol Screen. 2010;15:830-9 pubmed publisher
Po A, Ferretti E, Miele E, De Smaele E, Paganelli A, Canettieri G, et al. Hedgehog controls neural stem cells through p53-independent regulation of Nanog. EMBO J. 2010;29:2646-58 pubmed publisher
Lian Q, Zhang Y, Zhang J, Zhang H, Wu X, Zhang Y, et al. Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice. Circulation. 2010;121:1113-23 pubmed publisher
product information
Catalog Number :
MAB4343
Subcategory :
Epigenetics & Nuclear Function
Product Name :
Anti-SOX-2 Antibody
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Gene ID :
P48431
Host Name :
Mouse
Antigen :
SOX-2
Clone :
6F1.2
Conjugate :
Purified
Isotype :
IgG2b
Product Description :
Anti-SOX-2 Antibody
Cross Reactivity :
Human;Mouse
Background :
Sox-2 plays a key role in embryonic stem cell development, and has been shown to help stem cells maintain pluripotent potential. It has also been shown to be associated with uncommitted dividing stem cell and precursor cells of the developing CNS.
Immunogen :
Recombinant GST Fusion protein.
Package Size :
100 µg
Uses :
Immunocytochemistry;Immunohistochemistry;Western Blotting
Storage :
Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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