MDR1 Antibody, clone UIC2, Phycoerythrin conjugated | EMD Millipore MAB4334PE product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MDR1 Antibody, clone UIC2, Phycoerythrin conjugated

catalog :

MAB4334PE

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

UIC2

The same clone is also sold as:

Bio-Rad: MCA2671A488, MCA2671, MCA2671GA, MCA2671A647
BioLegend: 348609, 348616, 348606, 348610, 348613, 348611, 348607, 348618, 348605, 348614, 348602, 348608, 348615, 348617
OriGene: AM05632PU-N, AM05632PU-L
Bio X Cell: BE0340-50MG, BE0340-1MG, BE0340-25MG, BE0340-100MG, BE0340-5MG
Santa Cruz Biotechnology: sc-73354, sc-73354 L
Abcam: ab166957
Exbio: A6-764-T100, 11-764-C100, 11-764-C025, 12-764-C100, 1P-764-T100, 1P-764-T025, 1A-764-T100
LifeSpan Biosciences: LS-C58240
Invitrogen: 12-2439-42, MA5-16959, 17-2439-42, 46-2439-42, MA5-28587, 11-2439-42, 11-2439-41

reactivity :

human

application :

flow cytometry

citations: 7

Reference
Duran G, Wang Y, Francisco E, Rose J, Martinez F, Coller J, et al. Mechanisms of resistance to cabazitaxel. Mol Cancer Ther. 2015;14:193-201 pubmed publisher
Szwed M, Kania K, Jóźwiak Z. Relationship between therapeutic efficacy of doxorubicin-transferrin conjugate and expression of P-glycoprotein in chronic erythromyeloblastoid leukemia cells sensitive and resistant to doxorubicin. Cell Oncol (Dordr). 2014;37:421-8 pubmed publisher
Sun T, Wang Y, Wang F, Du J, Mao C, Sun C, et al. Cancer stem cell therapy using doxorubicin conjugated to gold nanoparticles via hydrazone bonds. Biomaterials. 2014;35:836-45 pubmed publisher
Tanaka T, Toujima S, Tanaka J. Differential sensitivity to paclitaxel-induced apoptosis and growth suppression in paclitaxel-resistant cell lines established from HEC-1 human endometrial adenocarcinoma cells. Int J Oncol. 2012;41:1837-44 pubmed publisher
Ritchie T, Kwon H, Atkins W. Conformational analysis of human ATP-binding cassette transporter ABCB1 in lipid nanodiscs and inhibition by the antibodies MRK16 and UIC2. J Biol Chem. 2011;286:39489-96 pubmed publisher
Lagadinou E, Ziros P, Tsopra O, Dimas K, Kokkinou D, Thanopoulou E, et al. c-Jun N-terminal kinase activation failure is a new mechanism of anthracycline resistance in acute myeloid leukemia. Leukemia. 2008;22:1899-908 pubmed publisher
Almond L, Hoggard P, Edirisinghe D, Khoo S, Back D. Intracellular and plasma pharmacokinetics of efavirenz in HIV-infected individuals. J Antimicrob Chemother. 2005;56:738-44 pubmed

product information

Catalog Number :

MAB4334PE

Subcategory :

Metabolism

Product Name :

Anti-MDR1 Antibody, clone UIC2, Phycoerythrin conjugated

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P08183

Host Name :

Mouse

Antigen :

MDR1

Clone :

UIC2

Conjugate :

Phycoerythrin

Isotype :

IgG2aκ

Product Description :

Anti-MDR1 Antibody, clone UIC2, Phycoerythrin conjugated

Cross Reactivity :

Human;Primate

Background :

UIC2 is a mouse monoclonal antibody directed against the extracellular conformational epitope of P-glycoprotein (Pgp). This antibody can be used in flow cytometry, immunofluorescence microscopy and immunohistochemistry in frozen and paraffin sections to detect Pgp expression on the membrane of MDR1 positive cells. In functional experiments, UIC2 was shown to inhibit Pgp-mediated efflux activity and potentiate the cytotoxic effects of chemotherapy drugs transported by Pgp. Additionally, the UIC2 monoclonal antibody can be used in combination with MDR1 substrates for simulatenaeous detection of Pgp expression and function by flow cytometry (Chemicon's UIC2 Shift assay - see product ECM905).

ALT Names :

P-glycoprotein; CD243; p170; Pgp

Immunogen :

Mouse BALB/c 3T3 fibroblasts transfected with human MDR1 cDNA, followed by a multistep selection of tranfectants for resistance to vinblastine.

Specificity :

P-glycoprotein encoded by the MDR1 gene (ABCB1; LocusLink ID: 5243)

Package Size :

100 µg

Uses :

Flow Cytometry

Storage :

Maintain at 2-8°C for up 12 months from date of receipt. Important Note: During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.