MDR1 Antibody, conformational extracellular epitope, clone UIC2 | EMD Millipore MAB4334 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MDR1 Antibody, conformational extracellular epitope, clone UIC2

catalog :

MAB4334

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

UIC2

The same clone is also sold as:

LifeSpan Biosciences: LS-C58240
Exbio: 12-764-C100, 1P-764-T100, 11-764-C025, A6-764-T100, 11-764-C100, 1A-764-T100, 1P-764-T025
Invitrogen: 12-2439-42, 11-2439-41, 17-2439-42, MA5-16959, MA5-28587, 11-2439-42, 46-2439-42
Santa Cruz Biotechnology: sc-73354 L, sc-73354
OriGene: AM05632PU-N, AM05632PU-L
Abcam: ab166957
Bio-Rad: MCA2671, MCA2671A647, MCA2671A488, MCA2671GA
BioLegend: 348618, 348608, 348611, 348609, 348613, 348617, 348605, 348606, 348615, 348610, 348614, 348602, 348607, 348616
Bio X Cell: BE0340-5MG, BE0340-1MG, BE0340-25MG, BE0340-50MG, BE0340-100MG

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, other

citations: 11

Published Application/Species/Sample/Dilution	Reference
other; human; 1:50; fig 3c	Midde N, Sinha N, Lukka P, Meibohm B, Kumar S. Alterations in cellular pharmacokinetics and pharmacodynamics of elvitegravir in response to ethanol exposure in HIV-1 infected monocytic (U1) cells. PLoS ONE. 2017;12:e0172628 pubmed publisher
immunocytochemistry; human	Szwed M, Kania K, Jóźwiak Z. Relationship between therapeutic efficacy of doxorubicin-transferrin conjugate and expression of P-glycoprotein in chronic erythromyeloblastoid leukemia cells sensitive and resistant to doxorubicin. Cell Oncol (Dordr). 2014;37:421-8 pubmed publisher
	Duran G, Wang Y, Francisco E, Rose J, Martinez F, Coller J, et al. Mechanisms of resistance to cabazitaxel. Mol Cancer Ther. 2015;14:193-201 pubmed publisher
	Sun T, Wang Y, Wang F, Du J, Mao C, Sun C, et al. Cancer stem cell therapy using doxorubicin conjugated to gold nanoparticles via hydrazone bonds. Biomaterials. 2014;35:836-45 pubmed publisher
	Tanaka T, Toujima S, Tanaka J. Differential sensitivity to paclitaxel-induced apoptosis and growth suppression in paclitaxel-resistant cell lines established from HEC-1 human endometrial adenocarcinoma cells. Int J Oncol. 2012;41:1837-44 pubmed publisher
	Fonsato V, Collino F, Herrera M, Cavallari C, Deregibus M, Cisterna B, et al. Human liver stem cell-derived microvesicles inhibit hepatoma growth in SCID mice by delivering antitumor microRNAs. Stem Cells. 2012;30:1985-98 pubmed publisher
	Ritchie T, Kwon H, Atkins W. Conformational analysis of human ATP-binding cassette transporter ABCB1 in lipid nanodiscs and inhibition by the antibodies MRK16 and UIC2. J Biol Chem. 2011;286:39489-96 pubmed publisher
	Davis D, Zhang Y, Smith R, Cheng K, Terrovitis J, Malliaras K, et al. Validation of the cardiosphere method to culture cardiac progenitor cells from myocardial tissue. PLoS ONE. 2009;4:e7195 pubmed publisher
	Lagadinou E, Ziros P, Tsopra O, Dimas K, Kokkinou D, Thanopoulou E, et al. c-Jun N-terminal kinase activation failure is a new mechanism of anthracycline resistance in acute myeloid leukemia. Leukemia. 2008;22:1899-908 pubmed publisher
	Shoemaker A, Mitten M, Adickes J, Ackler S, Refici M, Ferguson D, et al. Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft models. Clin Cancer Res. 2008;14:3268-77 pubmed publisher
	Almond L, Hoggard P, Edirisinghe D, Khoo S, Back D. Intracellular and plasma pharmacokinetics of efavirenz in HIV-infected individuals. J Antimicrob Chemother. 2005;56:738-44 pubmed

product information

Catalog Number :

MAB4334

Subcategory :

Metabolism

Product Name :

Anti-MDR1 Antibody, conformational extracellular epitope, clone UIC2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P08183

Host Name :

Mouse

Antigen :

MDR1

Clone :

UIC2

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-MDR1 Antibody, conformational extracellular epitope, clone UIC2

Cross Reactivity :

Human;Primate

Background :

UIC2 is a mouse monoclonal antibody directed against the extracellular conformational epitope of P-glycoprotein (Pgp). This antibody can be used in flow cytometry, immunofluorescence microscopy and immunohistochemistry in frozen and paraffin sections to detect Pgp expression on the membrane of MDR1 positive cells. In functional experiments, UIC2 was shown to inhibit Pgp-mediated efflux activity and potentiate the cytotoxic effects of chemotherapy drugs transported by Pgp. Additionally, the UIC2 monoclonal antibody can be used in combination with MDR1 substrates for simulatenaeous detection of Pgp expression and function by flow cytometry (MILLIPORE's UIC2 Shift assay - see product ECM905).

ALT Names :

P-glycoprotein; CD243; p170; Pgp

Immunogen :

Mouse BALB/c 3T3 fibroblasts transfected with human MDR1 cDNA, followed by a multistep selection of tranfectants for resistance to vinblastine.

Specificity :

P-glycoprotein encoded by the MDR1 gene (ABCB1; LocusLink ID: 5243)

Package Size :

100 µg

Uses :

Flow Cytometry;Immunofluorescence;Immunoprecipitation;Immunohistochemistry;Immunohistochemistry (Paraffin);Affects Function

Storage :

Maintain at 2-8°C for up 12 months from date of receipt.