Human Leukemia Inhibitory Factor Antibody, clone 4F7.2 | EMD Millipore MAB4306 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Human Leukemia Inhibitory Factor Antibody, clone 4F7.2

catalog :

MAB4306

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4F7.2

reactivity :

human

application :

western blot, ELISA

product information

Catalog Number :

MAB4306

Subcategory :

Stem Cell Research

Product Name :

Anti-Human Leukemia Inhibitory Factor Antibody, clone 4F7.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P15018

Host Name :

Mouse

Antigen :

Human Leukemia Inhibitory Factor

Clone :

4F7.2

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-Human Leukemia Inhibitory Factor Antibody, clone 4F7.2

Cross Reactivity :

Human;Mouse

Background :

Leukemia inhibitory factor, or LIF, is a pleiotropic cytokine that is expressed by a wide variety of cells including activated T lymphocytes, monocytes, mast cells and neuronal cells. Human LIF cDNA encodes a 202 amino acid precursor which is processed to yield a 180 amino acid, biologically active glycoprotein with an approximate molecular weight of 38-67 kDa. In addition to its involvement in the stimulation of acute-phase protein during inflammatory processes, LIF has also been implicated in promoting the survival and growth of axons in vitro. LIF signals through the LIF receptor, a heterodimer comprised of a 190 kDa LIFR subunit and the gp130 subunit common to the IL-6, IL-11, CNTF and OSM receptors. Janus tyrosine kinases, JAK1 and JAK2, are activated in response to LIF stimulation, which in turn phosphorylate Stat1 and Stat3 causing their nuclear translocation and the transcription of Stat-responsive genes.

ALT Names :

hLIF

Package Size :

100 µg

Uses :

ELISA;Western Blotting